Cetalkonium-d5-chloride-Benzyldimethylhexadecylammonium-d-sub-5-sub-chloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECetalkonium-d5chlorideCat.No.:HY-W724344Synonyms:Benzyldimethylhexadecylammonium-d5chloride分⼦式:C₂₅H₄₁D₅ClN分⼦量:401.12作⽤靶点:Isotope-LabeledCompounds;Bacterial作⽤通路:Others;Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Cetalkonium-d5chloride(Benzyldimethylhexadecylammonium-d5chloride)氘代标记的Cetalkoniumchloride(HY-B1597)。Cetalkoniumchloride⼀种铵盐防腐剂，可⽤于⼝腔，咽喉和眼睛感染的研究。Cetalkoniumchloride起消炎的作⽤。Cetalkoniumchloride⼀种阳离⼦表活性剂，可改药物在⾓膜前的停留时间和⽣物利⽤度。Cetalkoniumchloride与细细胞膜上的负电荷相互作⽤，破坏细胞膜的完整性，导致细胞内容物泄漏，最终导致细死亡[1][2][3]。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].CesarTorres-Luna,etal.FormationofDrug-ParticipatingCatanionicAggregatesforExtendedDeliveryofNon-SteroidalAnti-InflammatoryDrugsfromContactLenses.Biomolecules.2019Oct10;9(10):593.[2].DaullP,etal.,Benefitsofcetalkoniumchloridecationicoil-in-waternanoemulsionsfortopicalophthalmicdrugdelivery.JPharmPharmacol.2014Apr;66(4):531-41.[3].AmangeldykyzyS,etal.TheeffectofacombinedcholinesalicylateandcetalkoniumchloridegelonparticularstrainsofPseudomonasaeruginosa,Staphylococcusspp.andStreptococcusspp[J].CurrentIssuesinPharmacyandMedicalSciences,2015,28(2):78-80.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-