Citronellol-d3-racemic-Citronelloll-d-sub-3-sub-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECitronellol-d3Cat.No.:HY-W010201S1Synonyms:(±)-Citronelloll-d3;(±)-β-Citronelloll-d3分⼦式:C₁₀H₁₇D₃O分⼦量:159.28作⽤靶点:Isotope-LabeledCompounds;p62;Necroptosis;Atg8/LC3;

ReactiveOxygenSpecies(ROS);TNFReceptor;Autophagy;

ERK;Apoptosis;PI3K;Fungal作⽤通路:Others;Autophagy;Apoptosis;Immunology/Inflammation;

MetabolicEnzyme/Protease;NF-κB;MAPK/ERKPathway;

StemCell/Wnt;PI3K/Akt/mTOR;Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Citronellol-d3((±)-Citronelloll-d3)氘代标记的Citronellol(HY-W010201)。Citronellol((±)-Citronellol)⼀种⼝服有效的凋亡(apoptosis)诱导剂。Citronellol可以通过调节ROS-NO、MAPK/ERK和PI3K/Akt信号通路预防6-OHDA诱导的SH-SY5Y细胞帕⾦森病模型中的氧化应激、线粒体功能障碍和凋亡。Citronellol可以通过TNF-α途径和活性氧(ROS)积累诱导⼈肺癌细胞坏死性凋亡(necroptosis)。Citronellol可以降低LC-3和p62⽔平来调节⾃噬(autophagy)途径，抑制氧化应激和神经炎症，从⽽对帕⾦森⼤⿏具有神经保护作⽤。Citronellol通过抑制麦⾓甾醇合成从⽽对红⾊⽑癣具有抗真(fungal)活性。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].PereiraFdeO,etal.Antifungalactivityofgeraniolandcitronellol,twomonoterpenesalcohols,againstTrichophytonrubruminvolvesinhibitionofergosterolbiosynthesis.PharmBiol.2015Feb;53(2):228-34.[2].MunirS,etal.TheProtectiveEffectofCitronellolagainstDoxorubicin-InducedCardiotoxicityinRats.Biomedicines.2023Oct18;11(10):2820.[3].ShaoJ,etal.CitronellolPrevents6-OHDA-InducedOxidativeStress,MitochondrialDysfunction,andApoptosisinParkinsonDiseaseModelofSH-SY5YCellsviaModulatingROS-NO,MAPK/ERK,andPI3K/AktSignalingPathways.NeurotoxRes.2022Dec;40(6):2221-2237.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[4].SahliF,etal.Autoxidizedcitronellol:Freeradicalsaspotentialsparklestoignitethefragranceinducedskinsensitizingpathway.FoodChemToxicol.2022Aug;166:113201.[5].JayarajRL,etal.Effectofcitronellolonoxidativestress,neuroinflammationandautophagypathwaysinaninvivomodelofParkinson'sdisease.Heliyon.2022Nov3;8(11):e11434.[6].MahmoodYS,etal.Protectiveeffectofcitronellolinrhabdomyolysis-inducedacutekidneyinjuryinmice.JMedLife.2023Jul;16(7):1057-1061.[7].YuWN,etal.CitronellolInducesNecroptosisofHumanLungCancerCellsviaTNF-αPathwayandReactiveOxygenSpeciesAccumulation.InVivo.2019Jul-Aug;33(4):1193-1201.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalappli