疏肝散结饮治疗气郁痰阻型甲状腺结节的临床疗效观察及对VEGF、IGF-1的影响

疏肝散结饮治疗气郁痰阻型甲状腺结节的临床疗效观察及对VEGF、IGF-1的影响目的：探讨疏肝散结饮在治疗气郁痰阻型甲状腺结节中的临床疗效及其对血管内皮生长因子（VEGF）和胰岛素样生长因子-1（IGF-1）的影响。方法：选取气郁痰阻型甲状腺结节患者80例，随机分为治疗组和对照组，每组40例。治疗组给予疏肝散结饮治疗，对照组给予常规西药治疗。比较两组患者的治疗效果、VEGF、IGF-1水平的变化情况。结果：治疗组总有效率为92.5%，明显高于对照组的72.5%。治疗后，两组患者的VEGF、IGF-1水平均较治疗前有所降低，但治疗组下降幅度更大，且差异具有统计学意义。结论：疏肝散结饮能够有效改善气郁痰阻型甲状腺结节患者的临床症状，并显著降低VEGF、IGF-1水平，对治疗气郁痰阻型甲状腺结节具有一定的临床价值。关键词：气郁痰阻型甲状腺结节；疏肝散结饮；VEGF；IGF-1Abstract:Objective:ToinvestigatetheclinicalefficacyofShugāngSànjiēYèndecoctionintreatingqistagnationandphlegmobstructiontypethyroidnodules,aswellasitsimpactonvascularendothelialgrowthfactor(VEGF)andinsulin-likegrowthfactor-1(IGF-1).Methods:Atotalof80patientswithqistagnationandphlegmobstructiontypethyroidnoduleswereselectedandrandomlydividedintoatreatmentgroupandacontrolgroup,eachconsistingof40cases.ThetreatmentgroupwastreatedwithShugāngSànjiēYèndecoction,whilethecontrolgroupreceivedconventionalWesternmedicinetreatment.Thetherapeuticeffectsofbothgroupswerecompared,aswellasthechangesinVEGFandIGF-1levelsbeforeandaftertreatment.Results:Thetotaleffectiverateofthetreatmentgroupwas92.5%,significantlyhigherthanthatofthecontrolgroupat72.5%.Aftertreatment,thelevelsofVEGFandIGF-1inbothgroupsdecreasedcomparedtotheirpre-treatmentlevels,butthereductioninthetreatmentgroupwasgreater,andthisdifferencewasstatisticallysignificant.Conclusion:ShugāngSànjiēYèndecoctioncaneffectivelyimprovetheclinicalsymptomsofpatientswithqistagnationandphlegmobstructiontypethyroidnodules,andsignificantlyreduceVEGFandIGF-1levels.Ithascertainclinicalvalueintreatingqistagnationandphlegmobstructiontypethyroidnodules.Keywords:QiStagnationandPhlegmObstructionTypeThyroidNodules;ShugāngSànjiēYènDecoction;VEGF;IGF-1在本次研究中，我们观察到疏肝散结饮治疗组的总有效率显著高于对照组，达到92.5%，而对照组为72.5%。此外，治疗后两组患者的VEGF和IGF-1水平均有所下降，但治疗组下降幅度更大，且差异具有统计学意义。这些结果提示疏肝散结饮可能通过改善气郁痰阻型甲状腺结节患者的临床症状，并调节VEGF和IGF-1的水平，从而有效促进甲状腺结节的恢复。尽管本研究取得了积极的结果，但仍需进一步的研究来验证其长期效果和安全性。此外，考虑到不同个体对药物的反应可能存在差异，未来的