gpc-PrEP的概述相关知识 PrEP-it overview

PrEP-itoverviewFebruary2026WhatisPrEP-it?PrEP-it(PrEPImplementationplanning,monitoring,andevaluationTool)–wasdevelopedin2019andfundedbyPEPFAR/USAIDthroughtheHP+,OPTIONS,andEATAP-IIprojects.2021–2024itwasfurtherdevelopedandsupportedundertheMOSAICConsortium.

PrEP-itisadecision-makingandanalysistoolwithinterrelatedmodules:TargetsettingCostforecastingEstimatingimpactCommodityforecasting3CorePrEP-itfeaturesToolcanbeappliedatthenational,sub-national,donor,implementerorsitelevelToolcanbeappliedtomultiplePrEPmethodssimultaneouslyUserscansettargetsbasedonthedesiredcoveragefordifferentpopulationsortheycanmanuallyenterexistingtargetstoexplorerelatedcostsandimpactCostestimatesexaminecostsbyvisitandaccountfortheaveragelengthoftimePrEPclientsstayonPrEPandreturnvisitschedulesMonthlyforecastsofcommodityneedsandcostsareusefulforprogramplanningandsupplychainmanagementSomewayscountrieshaveusedPrEP-itTheMaliteamusedPrEP-itforsettingtargetsfortheirGlobalFundfundingrequest.TheMalawiMinistryofHealthusedPrEP-ittosupplementnationalPEPFARandGlobalFundPrEPtarget-setting,planning,andquantification.TheMOSAICteamsupportedZambiatosetitsfirstnationalPrEPtargetsusingPrEP-it.ZambiaalsousedPrEP-itforplanningtheirLenacapavirrolloutPEPFAR

Eswatini

usedPrEP-Ittoset

targetsforCOP23andtheirGlobalFundapplication.

USAIDMissionstaffinTanzaniausedPrEP-itforCOP(CountryOperationalPlan)planning.CountiesinKenyausedPrEP-it2.0tosettheiroralPrEPtargetsforspecificyears.TheSenegalteamusedPrEP-ittosettargetsfortheirGlobalFundfundingrequest.PrEP-itwasusedtosupportquantificationofPrEPcommoditiesfortargetssetbytheDRCintheirfundingsubmissiontotheGlobalFund.GhanausedPrEP-itfornationalPrEPtarget-settingfollowingparticipationinaUNAIDS/MOSAICworkshop.MozambiqueusedPrEP-itfornationalPrEPtarget-settingandsupportingfuturetrainings.JhpiegoLesothousedPrEP-ittosettargetsfortheircommunity-basedPrEPdeliveryprogram(KHANYA)forspecificfiscalyears.TheGlobalFundinthePhilippinesreceivedsupportfromtheMOSAICAvenirteamonhowtousePrEP-ittoestablishtargetsalignedwithGlobalFundindicators.Uganda'sMinistryofHealthusedPrEP-ittosetepidemiologicallyandcost-relevantPrEPtargetsforspecificyears.NigeriausedPrEP-itforplanningtheirLenacapavirrolloutUgandausedPrEP-ittosettheirnationalPrEPtargetsPopulationestimatesForeachprioritypopulation,fourinputsareneededtocalculatethenumberofpotentialusersofPrEPEstimatedtotalprioritypopulationsizePercentofeachPrEPpopulationlivingingeographicareasprioritizedforPrEPfortarget-settingHIVprevalencePercentindicatedforPrEP(%ofthatpopulationinneedofPrEPbasedontheirlikelihoodofexposuretoHIV)TotalPriorityPopulationSizeInPrioritizedAreasHIVnegativeInNeedofPrEPPotentialPrEPclientsMethodsBydefault,PrEP-itmodelsfourmethods:pill,ring,CAB,andLenacapavirUserscancustomizethemethodmixtoincludeothermethodsAddingamethodrequiresdataorassumptionsaboutcost,effectiveness,andimplementationtimeframePrEP-ittracksclientsovertimebasedonspecifiedcontinuationcurvesCostsandcost-effectivenessCostingmoduleincludesthreemaintypesofcosts:Monthlycosts(PrEPproduct,adherencesupport)Per-visitcosts(personnel,labs,recurrent,capital)Lumpsumcosts(demandcreation,management,training)Userscanselectwhichcostcategoriestoincludeintheestimateofthecostofthetargetsandcaninputcostsorrelyoncountry-specificdefaults,whicharebasedonanalysesofpriorprogramcostdataWhencombinedwithtargets,theresultsincludethetotalcostofachievingthetargetsandthecostperinfectionavertedbyPrEPmethodandpopulation,takingintoaccountcontinuation,reinitiation,visitschedules,andscale-uptrendsPrEP-itcalculatesthenumberofHIVinfectionsavertedbasedonthesettargetsand“impactfactors”–themodelednumberofHIVinfectionsavertedperperson-yearonPrEPTheimpactfactorswereestimatedusingtheSpectrum/GoalsModel,whichisamathematicalmodelofHIVepidemicdynamicsthatincludestheimpactofpreventionandtreatmentinterventionsImpactfactorsarecountry-,method-,andpopulation-specificandarebasedonmethodeffectiveness(efficacyxadherence)andprojectedincidenceineachpopulationTheresultscanbeusedtoestimatethecost-effectivenessofachievingthetargets,bypopulationandmethod,whenlinkedtothecostsmoduleEstimatingtheimpactofPrEPThreeoptionsgiveninthedropdownlist:Coverage–settargetsbasedonthepercentofpotentialusersineachprioritypopulationwhowillbeactivelytakingPrEPattheendofthetarget-settingperiod(e.g.,25%)NotethatcoverageinthiscaseisNOTdefinedasthepercentageofthepopulationwhohaseverinitiatedPrEPCoveragewithconstraints–constraincoverage-basedtargetsbytotalcostand/orquantitiesofeachproductavailableManual–enterthetargetnumberofinitiations(includingreinitiations)bymethodforeachprioritypopulationUserscanspecifyestimatedmethodmixwhensettingtargetsTarget-settingoptionsForeachmethod,tooldetailsthetotalPrEP_NEW,PrEP_CT,totalPrEPrecipients,andthenumbercurrentlyonPrEPinthefinalmonthofthetarget-settingperiodForeachpopulationandmethod,thetooloutputsthetotalinitiations,totalreinitiations,totalinfectionsaverted,costperinfectionaverted,actualcoverageachieved,andthepercentofpotentialusersexpectedtoinitiateoverthetarget-settingperiodOptionalfeaturetodisaggregatetargetstosubnationalareasCommoditiesforecastingshowsmonthlyestimatesofexpectedvisits,amountofPrEPproductneeded,andmonthlycommoditycostsTooloutputsComingin2026:PrEP-itSHIPPOptionalmodewiththeprimaryobjectiveistoincorporatetheSHIPPtoolpopulationsizeandHIVincidenceestimatesintoPrEP-itfortarget-settingThiswillassistusersto:DefineprioritypopulationsanddistrictsbasedonHIVincidenceinpopulation-distri