Gluconate-d6-sodium-D-Gluconic-acid-sodium-salt-d-sub-6-sub-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEGluconate-d6sodiumCat.No.:HY-B1092AS2Synonyms:D-Gluconicacidsodiumsalt-d6;SodiumD-gluconate-d6;D-Gluconatesodiumsalt-d6分⼦式:C₆H₅D₆NaO₇分⼦量:224.17作⽤靶点:Isotope-LabeledCompounds;InterleukinRelated;ERK;NOSynthase;EndogenousMetabolite作⽤通路:Others;Immunology/Inflammation;MAPK/ERKPathway;StemCell/Wnt;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Gluconate-d6sodium(D-Gluconicacidsodiumsalt-d6)氘代标记的Gluconatesodium(HY-B1092A)。Gluconatesodium(D-Gluconicacidsodiumsalt)⼀种⼝服葡萄糖衍⽣物。Gluconatesodium可减少⼀氧化氮(nitricoxide)和炎性细胞因⼦(IL-1β和IL-6)。Gluconatesodium可抑制ERK磷酸化。Gluconatesodium具有抗氧化和抗⾎⼩板活化活性。Gluconatesodium对抗结直肠癌具有抗肿瘤活性。Gluconatesodium可改⾻关节炎、肠道损伤和急性肺损伤[1][2][3][4][5][6][7]。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].RTouir,etal.Sodiumgluconateascorrosionandscaleinhibitorofordinarysteelinsimulatedcoolingwater.CorrosionScienceVolume50,Issue6,June2008,Pages1530-1537[2].Saluk-JuszczakJ.Acomparativestudyofantioxidativeactivityofcalcium-D-glucarate,sodium-D-gluconateandD-glucono-1,4-lactoneinahumanbloodplateletmodel.Platelets.2010;21(8):632-40.[3].KameueC,etal.Dietarysodiumgluconateprotectsratsfromlargebowelcancerbystimulatingbutyrateproduction.JNutr.2004Apr;134(4):940-4.[4].SaleemTH,etal.PossibleProtectiveEffectsofQuercetinandSodiumGluconateAgainstColonCancerInductionbyDimethylhydrazineinMice.AsianPacJCancerPrev.2015;16(14):5823-8.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[5].ZhangY,etal.DietarysupplementationwithsodiumgluconateimprovesthegrowthperformanceandintestinalfunctioninweanedpigschallengedwitharecombinantEscherichiacolistrain.BMCVetRes.2022Aug6;18(1):303.[6].KangSJ,etal.ProtectiveeffectsofcalciumgluconateonosteoarthritisinducedbyanteriorcruciateligamenttransectionandpartialmedialmeniscectomyinSprague-Dawleyrats.JOrthopSurgRes.2014Mar7;9(1):14.[7].LiuL,etal.Effectsofcalciumgluconateonlipopolysaccharide-inducedacutelunginjuryinmice.BiochemBiophysResCommun.2018Sep18;503(4):2931-2935.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplication