GNF-6231-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEGNF-6231(Standard)Cat.No.:HY-100408RCASNo.:1243245-18-2分子式:C₂₄H₂₅FN₆O₂分子量:448.49作用靶点:Wnt;Porcupine;ReferenceStandards作用通路:StemCell/Wnt;Others储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 GNF-6231(Standard)是GNF-6231(HY-100408)的分析标准品。本产品用于研究及分析应用。GNF-6231是一种具有口服活性Porcupine(IC50=0.8nM)、Pron和内质网蛋白抑制剂。GNF-6231具有抗癌活性。GNF-6231可以通过阻断所有Wnt配体的分泌来抑制Wnt通路的激活。GNF-6231可以用于心肌梗死的研究[1][2]<REFERENCESBastakoty,Dikshyaetal.Temporary,SystemicInhibitionoftheWNT/β-CateninPathwaypromotesRegenerativeCardiacRepairfollowingMyocardialInfarct.Cell,stemcellsandregenerativemedicinevol.2,2(2016):10.16966/2472-6990.111.Kang,Sheng.Low-densitylipoproteinreceptor-relatedprotein6-mediatedsignalingpathwaysandassociatedcardiovasculardiseases:diagnosticandtherapeuticopportunities.Humangeneticsvol.139,4(2020):447-459.Raeisi,Mortazaetal.Porcnasanoveltherapeutictargetincancertherapy: Areview.Cellbiologyinternationalvol.46,12(2022):1979-1991.Cheng,Daietal.DiscoveryofPyridinylAcetamideDerivativesasPotent,Selective,andOrallyBioavailablePorcupineInhibitors.ACSmedicinalchemistrylettersvol.7,7676-80.10May.2016,Bastakoty,Dikshyaetal.Temporary,SystemicInhibitionoftheWNT/β-CateninPathwaypromotesRegenerativeCardiacRepairfollowingMyocardialInfarct.Cell,stemcellsandregenerativemedicinevol.2,2(2016):10.16966/2472-6990.111.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589