Gy-CATH-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEGy-CATHCat.No.:HY-P11467分⼦式:C₁₁₈H₁₈₆N₂₈O₄₀S₂分⼦量:2701.03Sequence:Ala-Glu-Glu-Glu-Ala-Glu-Lys-Thr-His-Lys-Thr-Glu-Cys-Leu-Glu-Cys-Ile-Phe-Thr-Leu-Leu-Pro-Pro-Ala(Disulfidebridge:Cys13

-Cys16)SequenceShortening:AEEEAEKTHKTECLECIFTLLPPA(Disulfidebridge:Cys13-Cys16)作⽤靶点:Bacterial;p38MAPK;NF-κB;PERK;JNK作⽤通路:Anti-infection;MAPK/ERKPathway;NF-κB;CellCycle/DNADamage储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Gy-CATH⼀种离⼦抗(antimicrobial)肽。Gy-CATH可激活MAPK和NF-κB信号通路(磷酸化ERK、p38、JNK、p65和IκBα的⽔平升⾼)。Gy-CATH可上调三种⽣理性抗凝⾎通路的表达⽔平。Gy-CATH可抑制ADP、胶原蛋⽩和PMA诱导的⾎⼩板聚集。Gy-CATH本⾝不具有直接的抗活性，但对感染⾦⾊葡萄球、⼤肠杆和耐Methicillin(HY-121544)⾦⾊葡萄球的⼩⿏具有显著的预防作⽤。Gy-CATH具有强的免疫调节活性，可增强巨噬细胞和中性粒细胞介导的杀功能。Gy-CATH显著降低了肺纤维蛋⽩沉积的程度，并预防了⼩⿏的⾎栓形成[1][2]。REFERENCES[1].SuZ,etal.Progressintheclassification,optimization,activity,andapplicationofantimicrobialpeptides.FrontMicrobiol.2025Apr23;16:1582863.[2].HeY,etal.ANonbactericidalAnionicAntimicrobialPeptideProvidesProphylacticandTherapeuticEfficaciesagainstBacterialInfectionsinMicebyImmunomodulatory-AntithromboticDuality.JMedChem.2024May9;67(9):7487-7503.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021