K02288-GMP-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEK02288(GMP)Cat.No.:HY-12278GCASNo.:1431985-92-0分⼦式:C₂₀H₂₀N₂O₄分⼦量:352.38作⽤靶点:TGF-βReceptor作⽤通路:TGF-beta/Smad储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性K02288(GMP)GMP级别的K02288(HY-12278)。GMP级别的⼩分⼦可⽤做细胞疗法中的辅助试剂。K02288⼀种有效的⾻形态发⽣蛋⽩(BMP)I型受体抑制剂，抑制ALK1，ALK2，ALK6的IC50为1.8，1.1，6.4nM。对ALK3和ALK6的抑制稍弱，IC50在5-34nM之间。体外研究K02288(GMP)reducesarobustphosphorylationofSmad1/5/8inducedbyBMP4stimulation,withanapparentIC50of100nM.K02288(GMP)causesnearcompleteinhibitionofSmad2phosphorylationat0.5μM[1].K02288(GMP)bindstoALK1inanATP-mimeticfashionwithtwohydrogenbondstothekinasehinge.K02288(GMP)alsoinhibitsBMP9-ALK1signalling,andinducesahypersproutingphenotypeinHUVECs[2].体内研究K02288(GMP)(1μM)inducesdysfunctionalangiogenesisinachickembryoCAMmodel[2].户使⽤本产品发表的科研⽂献•ExpMolMed.2022Oct;54(10):1727-1740.•BioorgMedChemLett.2020Dec1;30(23):127608.•SSRN.2025Jul25.•bioRxiv.2025February21.Seemorecustomervalidationsonwww.MedChemEREFERENCES1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[1].SanvitaleCE,etal.AnewclassofsmallmoleculeinhibitorofBMPsignaling.PLoSOne.2013Apr30;8(4):e62721.[2].KerrG,etal.AsmallmoleculetargetingALK1preventsNotchcooperativityandinhibitsfunctionalangiogenesis.Angiogenesis.2015Apr;18(2):209-17.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589559