Necrosulfonamide-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemENecrosulfonamide(Standard)Cat.No.:HY-100573RCASNo.:1360614-48-7分子式:C₁₈H₁₅N₅O₆S₂分子量:461.47作用靶点:MixedLineageKinase;ReferenceStandards;Necroptosis;Pyroptosis;Caspase;NOD-likeReceptor(NLR);Keap1-Nrf2;TNFReceptor;InterleukinRelated;NOSynthase;HemeOxygenase(HO)作用通路:MAPK/ERKPathway;Others;Apoptosis;Immunology/Inflammation;NF-κB;MetabolicEnzyme/Protease储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 Necrosulfonamide(Standard)是Necrosulfonamide(HY-100573)的分析标准品。本产品用于研究及分析应用。Necrosulfonamide是一种MLKL和GasderminD(GSDMD)的抑制剂，能够分别抑制细胞的坏死性凋亡(necroptosis)和焦亡(pyroptosis)。Necrosulfonamide不影响上游信号的激活，是特异地抑制下游的执行器寡聚化步骤。NecREFERENCESSunL,etal.Mixedlineagekinasedomain-likeproteinmediatesnecrosissignalingdownstreamofRIP3kinase.Cell.2012;148(1-2):213-227.YangW,etal.NecrosulfonamideamelioratesintestinalinflammationviainhibitingGSDMD-medicatedpyroptosisandMLKL-mediatednecroptosis.BiochemPharmacol.2022Dec;206:115338.ZhouXY,etal.ThebrainprotectionofMLKLinhibitornecrosulfonamideagainstfocalischemia/reperfusioninjuryassociatingwithblockingthenucleusandnuclearenvelopetranslocationofMLKLandRIP3K.FrontPharmacol.2023Oct24;14:1157054.ZhangJ,WeiK.Necrosulfonamidereversespyroptosis-inducedinhibitionofproliferationanddifferentiationofosteoblaststhroughtheNLRP3/caspase-1/GSDMDpathway.ExpCellRes.2021Aug15;405(2):112648.LiuY,etal.NecrosulfonamidepromoteshairgrowthandamelioratesDHT-inducedhairgrowthinhibition.JDermatolSci.2024Aug;115(2):64-74.WuYL,etal.GasderminDInhibitorNecrosulfonamideAlleviatesLipopolysaccharide/D-galactosamine-inducedAcuteLiverFailureinMice.JClinTranslHepatol.2022Dec28;10(6):1148-1154.KimDY,LeemYH,KimHS.MLKLInhibitorReducesOxidativeStress,Inflammation,andDopaminergicNeuronalCellDeathinMPTP-1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEInducedParkinson'sDiseaseMouseModel.BiomolTher(Seoul).2025May1;33(3):429-437.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseon