Norquetiapine-dihydrochloride-N-Desalkylquetiapine-dihydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemENorquetiapinedihydrochlorideCat.No.:HY-W040555CASNo.:111974-74-4Synonyms:N-Desalkylquetiapinedihydrochloride分⼦式:C₁₇H₁₉Cl₂N₃S分⼦量:368.32作⽤靶点:DrugMetabolite;5-HTReceptor;HCNChannel;SerotoninTransporter作⽤通路:MetabolicEnzyme/Protease;GPCR/GProtein;NeuronalSignaling;MembraneTransporter/IonChannel储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1monthBIOLOGICALACTIVITY⽣物活性Norquetiapine(N-Desalkylauetiapine)dihydrochlorideQuetiapine(HY-14544)的代谢物，⼀种选择性HCN1通道抑制剂，IC50为13.9μM。Norquetiapinedihydrochloride选择性地抑制去甲肾上腺素再摄取，5-HT1A(Ki=45nM)受体的部分激动剂，并作为前突触α2(Ki=237nM)、5-HT2C(Ki=107nM)和5-HT7(Ki=76nM)受体的拮抗剂。Norquetiapinedihydrochloride以状态依赖的⽅式阻断⼈体⼼脏钠通道Nav1.5。Norquetiapinedihydrochloride在LPS(HY-D1056)注射的C57BL/6⼩⿏中显⽰出部分抗炎作⽤。Norquetiapinedihydrochloride可⽤于抑郁症和炎症研究。户使⽤本产品发表的科研⽂献•DrugMetabDispos.2025Sep24.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].KimDH,ParkKS,ParkSH,HahnSJ,ChoiJS.NorquetiapineblocksthehumancardiacsodiumchannelNav1.5inastate-dependentmanner.EurJPharmacol.2020Oct15;885:173532.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[2].JeanJacquesA,etal.InhibitionofHCN1currentsbynorquetiapine,anactivemetaboliteoftheatypicalanti-psychoticdrugquetiapine.FrontPharmacol.2024Oct7;15:1445509.[3].JaehneEJ,etal.Theeffectoftheantipsychoticdrugquetiapineanditsmetabolitenorquetiapineonacuteinflammation,memoryandanhedonia.PharmacolBiochemBehav.2015Aug;135:136-44.[4].López-MuñozF,etal.Activemetabolitesasantidepressantdrugs:theroleofnorquetiapineinthemechanismofactionofquetiapineinthetreatmentofmooddisorders.FrontPsychiatry.2013Sep12;4:102.[5].JensenNH,etal.N-desalkylquetiapine,apotentnorepinephrinereuptakeinhibitorandpartial5-HT1Aagonist,asaputativemediatorofquetiapine'santidepressantactivity.Neuropsychopharmacology.2008Sep;33(10):2303-12.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Te