【海洋微生物天然产物的研究进展文献综述2700字】

海洋微生物天然产物的研究进展文献综述海洋微生物活性代谢产物研究始于上世纪40年代，但其发展过程却比较迟缓。1945年，GiuseppeBrotzu从海洋污泥中分离到海洋真菌Cephalosporiumacremonium，Abraham和Newton从其发酵产物中分离出具有抗菌活性的头孢菌素钠和头孢菌素C。头孢菌素钠（Cephalosporinnatrium）成为开发海洋新抗生素药的首例ADDINEN.CITE<EndNote><Cite><Author>史清文</Author><Year>2009</Year><RecNum>112</RecNum><DisplayText><styleface="superscript">[4]</style></DisplayText><record><rec-number>112</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612699570">112</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>史清文</author><author>霍长虹</author><author>李力更</author><author>张嫚丽</author></authors></contributors><titles><title>海洋天然产物化学研究的历史回顾</title><secondary-title>中草药</secondary-title></titles><periodical><full-title>中草药</full-title></periodical><pages>1687-1695</pages><number>11</number><keywords><keyword>海洋天然产物化学</keyword><keyword>海洋药物</keyword><keyword>历史回顾</keyword></keywords><dates><year>2009</year></dates><urls></urls></record></Cite></EndNote>[4]。此后，关于海洋微生物活性代谢产物的报道极少。随着各种2D-NMR技术和软离子技术的发展以及化学分离方法的快速发展，促进天然产物的分离和结构鉴定，促进了海洋微生物次级代谢产物的发展ADDINEN.CITE<EndNote><Cite><Author>史清文</Author><Year>2009</Year><RecNum>112</RecNum><DisplayText><styleface="superscript">[4]</style></DisplayText><record><rec-number>112</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612699570">112</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>史清文</author><author>霍长虹</author><author>李力更</author><author>张嫚丽</author></authors></contributors><titles><title>海洋天然产物化学研究的历史回顾</title><secondary-title>中草药</secondary-title></titles><periodical><full-title>中草药</full-title></periodical><pages>1687-1695</pages><number>11</number><keywords><keyword>海洋天然产物化学</keyword><keyword>海洋药物</keyword><keyword>历史回顾</keyword></keywords><dates><year>2009</year></dates><urls></urls></record></Cite></EndNote>[4]。1990年起，天然产物研究者从大批海洋微生物中分析出了许多化学组成结构新颖、独特且又具有生物活性的化合物。从中分离获得的新型化合物数量表现逐年增加的趋势，这些新化合物的化学结构和生物活性也趋于丰富和多样化ADDINEN.CITE<EndNote><Cite><Author>许建林</Author><RecNum>120</RecNum><DisplayText><styleface="superscript">[12]</style></DisplayText><record><rec-number>120</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612749793">120</key></foreign-keys><ref-typename="Thesis">32</ref-type><contributors><authors><author>许建林</author></authors></contributors><titles><title>海洋真菌Westerdykelladispersa和Phomopsislithocarpus次级代谢产物及其生物活性研究</title></titles><keywords><keyword>海洋真菌</keyword><keyword>Westerdykelladispersa</keyword><keyword>Phomopsislithocarpus</keyword><keyword>次级代谢产物</keyword><keyword>生物活性</keyword></keywords><dates></dates><publisher>广东药科大学</publisher><urls></urls></record></Cite></EndNote>[12]。海洋微生物能够产生具有多种药理活性的生物分子，如抗癌、抗炎、抗糖尿病和抗生素等ADDINEN.CITE<EndNote><Cite><Author>Rateb</Author><Year>2011</Year><RecNum>121</RecNum><DisplayText><styleface="superscript">[13]</style></DisplayText><record><rec-number>121</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612749793">121</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Rateb,MostafaE.</author><author>Ebel,Rainer</author></authors></contributors><titles><title>Secondarymetabolitesoffungifrommarinehabitats</title><secondary-title>NaturalProductReports</secondary-title></titles><periodical><full-title>NaturalProductReports</full-title></periodical><pages>290-344</pages><volume>28</volume><number>2</number><keywords><keyword>biochemistry,review</keyword></keywords><dates><year>2011</year></dates><urls></urls></record></Cite></EndNote>[13]。其结构类型主要有生物碱、肽、聚酮、萜、甾体、聚酮等。新型抗生素的研究是对抗多重耐药性（MDR）的重要方法。研究未开发的海洋微生物（例如细菌和真菌）及其代谢产物，可能会分离得到新抗生素ADDINEN.CITE<EndNote><Cite><Author>Lee</Author><Year>2015</Year><RecNum>122</RecNum><DisplayText><styleface="superscript">[14]</style></DisplayText><record><rec-number>122</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612750165">122</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Lee</author><author>Ventola</author></authors></contributors><titles><title>Theantibioticresistancecrisis:part1:causesandthreats</title><secondary-title>P&TAPeerReviewedJournalforFormularyManagement</secondary-title></titles><periodical><full-title>P&TAPeerReviewedJournalforFormularyManagement</full-title></periodical><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>[14]。Zhou等分离出的一株链霉菌StreptomycesdrozdowicziiSCSIO10141。从该菌的代谢产物中分离得到环肽类化合物marfomycinsA(1),B(2),andE(3)，在革兰氏阳性菌和革兰氏阴性菌抗菌生物活性测试中，化合物1，2，3对藤黄微球菌M.luteus具有选择性抗感染活性，其最低抑菌浓度值分别为0.25，4，和4µg/mLADDINEN.CITE<EndNote><Cite><Author>Zhou</Author><Year>2014</Year><RecNum>123</RecNum><DisplayText><styleface="superscript">[15]</style></DisplayText><record><rec-number>123</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612752370">123</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Zhou,Xiao</author><author>Huang,Hongbo</author><author>Li,Jie</author><author>Song,Yongxiang</author><author>Jiang,Renwang</author><author>Liu,Jing</author><author>Zhang,Si</author><author>Hua,Yan</author><author>Ju,Jianhua</author></authors></contributors><titles><title>Newanti-infectivecycloheptadepsipeptidecongenersandabsolutestereochemistryfromthedeepsea-derivedStreptomycesdrozdowicziiSCSIO10141</title><secondary-title>Tetrahedron</secondary-title></titles><periodical><full-title>Tetrahedron</full-title></periodical><pages>7795-7801</pages><volume>2014,70(42)</volume><number>-</number><keywords><keyword>Cycloheptapeptide</keyword><keyword>Streptomycesdrozdowiczii</keyword><keyword>Anti-infective</keyword><keyword>Marine-derivedactinomycete</keyword><keyword>MarformycinsA-F</keyword></keywords><dates><year>2014</year></dates><urls></urls></record></Cite></EndNote>[15]。Guo等从胶州湾分离得到青霉菌Penicilliumsp.F23-2,从该株青霉代谢产物中分离到化合物penicyclonesA−E(4-8),化合物4-8对金黄色葡萄球菌的生长具有抑制作用，MIC为0.3-1.0µg/mLADDINEN.CITE<EndNote><Cite><Author>Guo</Author><Year>2015</Year><RecNum>124</RecNum><DisplayText><styleface="superscript">[16]</style></DisplayText><record><rec-number>124</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612752370">124</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Guo,Wenqiang</author><author>Zhang,Zhenzhen</author><author>Zhu,Tianjiao</author><author>Gu,Qianqun</author><author>Li,Dehai</author></authors></contributors><titles><title>PenicyclonesA-E,AntibacterialPolyketidesfromtheDeep-Sea-DerivedFungusPenicilliumsp.F23-2</title><secondary-title>JournalofNaturalProducts</secondary-title></titles><periodical><full-title>JournalofNaturalProducts</full-title></periodical><pages>2699-703</pages><volume>78</volume><number>11</number><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>[16]。2013年，Song等从中国南海沉积物中分离得到一株链霉菌StreptomycesniveusSCSIO34064，从该株菌的发酵液中分离得到4个新的倍半萜类蒽醌sesquiterpenoidnaphthoquinones,marfuraquinocinsA–D(9-12),和2个新的香叶基化吩嗪,phenaziterpenesA(13)andB(14)。在细胞毒性和抗菌活性测定中，化合物9和11能抑制NCI-H460系列癌细胞生长，半抑制浓度IC50值分别为3.7和4.4μM。化合物9、11、12对S.aureusATCC29213的生长有抑制作用，其等效最小抑菌浓度为8μg/mL，化合物11、12显示对抗耐甲氧西林表皮葡萄球菌shhs-E1具有抗菌活性，MIC值为8μg/mLADDINEN.CITE<EndNote><Cite><Author>Song</Author><Year>2013</Year><RecNum>125</RecNum><DisplayText><styleface="superscript">[17]</style></DisplayText><record><rec-number>125</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612752370">125</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Song,Yongxiang</author><author>Huang,Hongbo</author><author>Chen,Yuchan</author><author>Ding,Jie</author><author>Zhang,Yun</author><author>Sun,Aijun</author><author>Zhang,Weimin</author><author>Ju,Jianhua</author></authors></contributors><titles><title>CytotoxicandAntibacterialMarfuraquinocinsfromtheDeepSouthChinaSea-DerivedStreptomycesniveusSCSIO3406</title><secondary-title>JournalofNaturalProducts</secondary-title></titles><periodical><full-title>JournalofNaturalProducts</full-title></periodical><pages>2263-8</pages><volume>76</volume><number>12</number><keywords><keyword>Humans</keyword><keyword>Streptomyces</keyword><keyword>Staphylococcusaureus</keyword><keyword>Staphylococcusepidermidis</keyword><keyword>Phenazines</keyword><keyword>Sesquiterpenes</keyword><keyword>Anti-BacterialAgents</keyword><keyword>MicrobialSensitivityTests</keyword><keyword>MagneticResonanceSpectroscopy</keyword><keyword>DrugScreeningAssays,Antitumor</keyword></keywords><dates><year>2013</year></dates><urls></urls></record></Cite></EndNote>[17]。Ma等从海洋来源青霉菌PenicilliumminioluteumZZ1657中分离得到4个新化合物，3个drimane倍半萜类化合物purpuridesE-G(15-17)和1个异香豆素penisocoumarinH（18），以及15个已知化合物。化合物15和16对耐甲氧西林金黄色葡萄球菌、大肠杆菌和白色念珠菌具有抗菌活性，MIC值分别为6-12和3-6μg/mLADDINEN.CITE<EndNote><Cite><Author>Ma</Author><Year>2019</Year><RecNum>126</RecNum><DisplayText><styleface="superscript">[18]</style></DisplayText><record><rec-number>126</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612752370">126</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Ma,Mingzhu</author><author>Ge,Hengju</author><author>Yi,Wenwen</author><author>Wu,Bin</author><author>Zhang,Zhizhen</author></authors></contributors><titles><title>Bioactivedrimanesesquiterpenoidsandisocoumarinsfromthemarine-derivedfungusPenicilliumminioluteumZZ1657</title><secondary-title>TetrahedronLetters</secondary-title></titles><periodical><full-title>TetrahedronLetters</full-title></periodical><pages>151504</pages><volume>61</volume><number>7</number><dates><year>2019</year></dates><urls></urls></record></Cite></EndNote>[18]。2015年，Nong等从中国海南柳珊瑚样品中分离得到Streptomycessp.SCSGAA0027。对该株链霉菌的代谢产物中分离得到4个具有新碳骨架的多元醇聚酮类化合物nahuoicacidsB-E（19-22），4个化合物对希瓦氏菌ShewanellaonedensisMR-1的生物膜有较弱的抑制作用ADDINEN.CITE<EndNote><Cite><Author>Nong</Author><Year>2015</Year><RecNum>127</RecNum><DisplayText><styleface="superscript">[19]</style></DisplayText><record><rec-number>127</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612752370">127</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Nong,XuHua</author><author>Zhang,XiaoYong</author><author>Xu,XinYa</author><author>Wang,Jie</author><author>Qi,ShuHua</author></authors></contributors><titles><title>NahuoicAcidsB-E,PolyhydroxyPolyketidesfromtheMarine-DerivedStreptomycessp.SCSGAA0027</title><secondary-title>JournalofNaturalProducts</secondary-title></titles><periodical><full-title>JournalofNaturalProducts</full-title></periodical><pages>141</pages><volume>79</volume><number>1</number><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>[19]。2017年，Nong等再次研究该株菌的代谢产物，从中分离到5个新化合物，其中pteridicacidsE(23)、pteridicacidsF（24）、pteridicacidsG（25）能够抑制枯草芽孢杆菌Bacillussubtilis的生长。在滤纸片含有50μg样品时，抑菌圈直径分别为8、7、7mmADDINEN.CITE<EndNote><Cite><Author>Xu-Hua</Author><Year>2017</Year><RecNum>128</RecNum><DisplayText><styleface="superscript">[20]</style></DisplayText><record><rec-number>128</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612752370">128</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Xu-Hua</author><author>Nong</author><author>Xiao-Yi</author><author>Wei</author><author>Shu-Hua</author><author>Qi</author></authors></contributors><titles><title>PteridicacidsC–Gspirocyclicpolyketidesfromthemarine-derivedStreptomycessp.SCSGAA0027</title><secondary-title>JournalofAntibiotics</secondary-title></titles><periodical><full-title>JournalofAntibiotics</full-title></periodical><dates><year>2017</year></dates><urls></urls></record></Cite></EndNote>[20]。许多传染性疾病的治疗方法是有限的，特别是由病毒病原体引起的疾病，需要新药来进行治疗ADDINEN.CITE<EndNote><Cite><Author>a</Author><Year>2010</Year><RecNum>129</RecNum><DisplayText><styleface="superscript">[21]</style></DisplayText><record><rec-number>129</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612752370">129</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>JarredYasuhara-Bella</author><author>YuananLub</author></authors></contributors><titles><title>Marinecompoundsandtheirantiviralactivities-ScienceDirect</title><secondary-title>AntiviralRes</secondary-title></titles><periodical><full-title>AntiviralRes</full-title></periodical><pages>231-240</pages><volume>86</volume><number>3</number><keywords><keyword>Marinemicroorganisms</keyword><keyword>Marinecompounds</keyword><keyword>Antiviralactivities</keyword></keywords><dates><year>2010</year></dates><urls></urls></record></Cite></EndNote>[21]。海洋来源微生物是开发针对不同重要病毒的新抗病毒药物的巨大来源ADDINEN.CITE<EndNote><Cite><Author>Moghadamtousi</Author><Year>2015</Year><RecNum>130</RecNum><DisplayText><styleface="superscript">[22]</style></DisplayText><record><rec-number>130</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612752370">130</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Moghadamtousi,Soheil</author><author>Nikzad,Sonia</author><author>Kadir,Habsah</author><author>Abubakar,Sazaly</author><author>Zandi,Keivan</author></authors></contributors><titles><title>PotentialAntiviralAgentsfromMarineFungi:AnOverview</title><secondary-title>MarineDrugs</secondary-title></titles><periodical><full-title>MarineDrugs</full-title></periodical><pages>4520-4538</pages><volume>13</volume><number>7</number><keywords><keyword>naturalproducts</keyword><keyword>marinefungi</keyword><keyword>antiviral</keyword><keyword>review</keyword></keywords><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>[22]。Luo等人从红树林来源海洋真菌Diaporthesp.SCSIO41011中分离得到28个化合物，并测试了这28个化合物对不同IAV亚型的抗病毒效果，包括A/PuertoRico/8/34H274Y(H1N1)、A/FM-1/1/47(H1N1)和A/Aichi/2/68(H3N2)。化合物39、40、51对上述3种亚型表现出显著的抗IAV活性，IC50范围在2.56-21.80μM。此外化合物14和26对A/FM-1/1/47(H1N1)和A/Aichi/2/68(H3N2)呈现剂量依赖性ADDINEN.CITE<EndNote><Cite><Author>Luo</Author><Year>2018</Year><RecNum>131</RecNum><DisplayText><styleface="superscript">[23]</style></DisplayText><record><rec-number>131</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612752370">131</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Luo,Xiaowei</author><author>Yang,Jie</author><author>Chen,Feimin</author><author>Lin,Xiuping</author><author>Chen,Chunmei</author><author>Zhou,Xuefeng</author><author>Liu,Shuwen</author><author>Liu,Yonghong</author></authors></contributors><titles><title>StructurallyDiversePolyketidesFromtheMangrove-DerivedFungusDiaporthesp.SCSIO41011WithTheirAnti-influenzaAVirusActivities</title><secondary-title>FrontiersinChemistry</secondary-title></titles><periodical><full-title>FrontiersinChemistry</full-title></periodical><pages>282-</pages><volume>6</volume><keywords><keyword>Diaporthesp.</keyword><keyword>polyketides</keyword><keyword>cytosporones</keyword><keyword>phthalides</keyword><keyword>anti-influenzaAvirus</keyword></keywords><dates><year>2018</year></dates><urls></urls></record></Cite></EndNote>[23]。2014年，Chen等从一株曲霉中分离到22-O-(N-Me-L-valyl)-aflaquinoloneB，22-O-(N-Me-L-valyl)-21-epi-aflaquinoloneB（54−55）。化合物55对呼吸道合胞体病毒（RSV）具有非常强的抑制活性，其IC50值为0.042µMADDINEN.CITE<EndNote><Cite><Author>Chen</Author><Year>2014</Year><RecNum>132</RecNum><DisplayText><styleface="superscript">[24]</style></DisplayText><record><rec-number>132</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612754106">132</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Chen,Min</author><author>Shao,ChangLun</author><author>Meng,Hong</author><author>She,ZhiGang</author><author>Wang,ChangYun</author></authors></contributors><titles><title>Anti-RespiratorySyncytialVirusPrenylatedDihydroquinoloneDerivativesfromtheGorgonian-DerivedFungusAspergillussp.XS-20090B15</title><secondary-title>JournalofNaturalProducts</secondary-title></titles><periodical><full-title>JournalofNaturalProducts</full-title></periodical><pages>2720-4</pages><volume>77</volume><number>12</number><dates><year>2014</year></dates><urls></urls></record></Cite></EndNote>[24]。Fan等人从海南文昌红树林分离得到一株耐酸青霉PenicilliumcamenbertiOUCMDZ-1492。从该株青霉的发酵液中分离得到6个新结构的吲哚二萜类化合物，化合物56-60表现出显著的抗H1N1病毒活性，IC50值分别为28.3、38.9、32.2、73.3、和34.1μMADDINEN.CITE<EndNote><Cite><Author>Fan</Author><Year>2013</Year><RecNum>133</RecNum><DisplayText><styleface="superscript">[25]</style></DisplayText><record><rec-number>133</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612754106">133</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Fan,Yaqin</author><author>Wang,Yi</author><author>Liu,Peipei</author><author>Fu,Peng</author><author>Zhu,Weiming</author></authors></contributors><titles><title>Indole-DiterpenoidswithAnti-H1N1ActivityfromtheAciduricFungusPenicilliumcamembertiOUCMDZ-1492</title><secondary-title>JournalofNaturalProducts</secondary-title></titles><periodical><full-title>JournalofNaturalProducts</full-title></periodical><pages>1328-1336</pages><volume>76</volume><number>7</number><keywords><keyword>Rhizophoraceae</keyword><keyword>Diterpenes</keyword><keyword>Indoles</keyword><keyword>AntiviralAgents</keyword><keyword>MolecularStructure</keyword><keyword>InfluenzaAVirus,H1N1Subtype</keyword><keyword>Penicillium</keyword><keyword>InhibitoryConcentration50</keyword><keyword>China</keyword></keywords><dates><year>2013</year></dates><urls></urls></record></Cite></EndNote>[25]。Pang等人从海绵中分离得到一株木霉属真菌Trichodermasp.SCSIO41004。从该株木霉次级代谢产物中分离得到3种新结构聚酮化合物trichbenzoisochromenA(61)、5,7-dihydroxy-3-methyl-2-(2-oxopropyl)naphthalene-1,4-dione(62)、7-acetyl-1,3,6-trihydroxyanthracene-9,10-dione(63)和6个已知的化合物64-69。其中化合物64能有效抑制肠道病毒EV71的活性，IC50为25.7μMADDINEN.CITE<EndNote><Cite><Author>Pang</Author><Year>2017</Year><RecNum>134</RecNum><DisplayText><styleface="superscript">[26]</style></DisplayText><record><rec-number>134</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612754106">134</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Pang,Xiaoyan</author><author>Lin,Xiuping</author><author>Tian,Yongqi</author><author>Liang,Rui</author><author>Wang,Junfeng</author><author>Yang,Bin</author><author>Zhou,Xuefeng</author><author>Kaliyaperumal,Kumaravel</author><author>Luo,Xiaowei</author><author>Tu,Zhengchao</author></authors></contributors><titles><title>Threenewpolyketidesfromthemarinesponge-derivedfungusTrichodermasp.SCSIO41004</title><secondary-title>NaturalProductResearch</secondary-title></titles><periodical><full-title>NaturalProductResearch</full-title></periodical><pages>1-7</pages><keywords><keyword>sponge-derivedfungus</keyword></keywords><dates><year>2017</year></dates><urls></urls></record></Cite></EndNote>[26]。具有独特的抑制肿瘤生长的生物活性的海洋微生物次级代谢产物，可作为新结构化疗药物和先导化合物ADDINEN.CITE<EndNote><Cite><Author>Bae</Author><Year>2020</Year><RecNum>135</RecNum><DisplayText><styleface="superscript">[27]</style></DisplayText><record><rec-number>135</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612754106">135</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Bae</author><author>Liao</author><author>Park</author><author>Kim</author><author>Lee</author></authors></contributors><titles><title>AntitumorActivityofAsperpheninA,aLipopeptidylBenzophenonefromMarine-DerivedAspergillussp.Fungus,byInhibitingTubulinPolymerizationinColonCancerCells</title><secondary-title>MarineDrugs</secondary-title></titles><periodical><full-title>MarineDrugs</full-title></periodical><pages>110</pages><volume>18</volume><number>2</number><keywords><keyword>marinemicroorganismmetabolite</keyword></keywords><dates><year>2020</year></dates><urls></urls></record></Cite></EndNote>[27]。Meng等从采集在中国海南岛的红树林植物海榄雌（Avicenniamarina）中分离得到PenicilliumbrocaeMA-231。从代谢产物中分离得到新结构化合物brocazinesA−F(70−75)。化合物70、71、74和75对肿瘤细胞系Du145、Hela、HepG2、MCF-7、NCI-H460、SGC-7901、SW1990、SW480和U251具有显著的抑制活性，其IC50为0.89~9.0µMADDINEN.CITE<EndNote><Cite><Author>Meng</Author><Year>2014</Year><RecNum>136</RecNum><DisplayText><styleface="superscript">[28]</style></DisplayText><record><rec-number>136</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612754106">136</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Meng</author><author>LH</author><author>XM</author><author>CT</author><author>Huang</author><author>CG</author><author>Wang</author><author>BG</author></authors></contributors><titles><title>BrocazinesA-F,CytotoxicBisthiodiketopiperazineDerivativesfromPenicilliumbrocaeMA-231,anEndophyticFungusDerivedfromtheMarineMangrovePlantAvicenniamarina</title><secondary-title>JournalofNaturalProducts</secondary-title></titles><periodical><full-title>JournalofNaturalProducts</full-title></periodical><keywords><keyword>EPICOCCUM-NIGRUM</keyword><keyword>THIODIKETOPIPERAZINES</keyword><keyword>METABOLITES</keyword></keywords><dates><year>2014</year></dates><urls></urls></record></Cite></EndNote>[28]。Martucci等从一株链霉菌分离得到化合物tetronasin(76)、naphthablinA(77)和2个新的萘醌杂萜类化合物naphthablinsB(78)andC(79)。化合物76对HeLa细胞显示出明显的细胞毒活性，IC50为0.23µM，化合物78、79在浓度为33µM时，对HeLa细胞具有弱抑制作用，抑制率为25%和32%ADDINEN.CITE<EndNote><Cite><Author>Martucci</Author><Year>2017</Year><RecNum>137</RecNum><DisplayText><styleface="superscript">[29]</style></DisplayText><record><rec-number>137</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612754106">137</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Martucci,Hana</author><author>Campit,ScottE.</author><author>Gee,StephanieR.</author><author>Bray,WalterM.</author><author>Gokey,Trevor</author><author>Cada,A.King</author><author>Yen,TenYang</author><author>Minoura,Katsuhiko</author><author>Guliaev,AntonB.</author><author>Lokey,R.Scott</author></authors></contributors><titles><title>NaphthablinsBandC,MeroterpenoidsIdentifiedfromtheMarineSediment-DerivedStreptomycessp.CP26-58UsingHeLaCell-BasedCytologicalProfiling</title><secondary-title>JournalofNaturalProducts</secondary-title></titles><periodical><full-title>JournalofNaturalProducts</full-title></periodical><pages>684</pages><volume>80</volume><number>3</number><dates><year>2017</year></dates><urls></urls></record></Cite></EndNote>[29]。Igarashi等从芽孢杆菌Brevibacillussp.TP-B0800分离得到两种结构独特的多环二氢噻唑类化合物ulbactinF（80）和G（81）。80和81在非细胞毒性浓度下能抑制表皮样癌A431细胞的迁移，IC50值分别为6.4和6.1µMADDINEN.CITE<EndNote><Cite><Author>Igarashi</Author><Year>2016</Year><RecNum>138</RecNum><DisplayText><styleface="superscript">[30]</style></DisplayText><record><rec-number>138</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612754106">138</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Igarashi,Yasuhiro</author><author>Asano,Daisuke</author><author>Sawamura,Masashi</author><author>In,Yasuko</author><author>Ishida,Toshimasa</author><author>Imoto,Masaya</author></authors></contributors><titles><title>UlbactinsFandG,PolycyclicThiazolineDerivativeswithTumorCellMigrationInhibitoryActivityfromBrevibacillussp</title><secondary-title>Cheminform</secondary-title></titles><periodical><full-title>Cheminform</full-title></periodical><volume>18</volume><number>32</number><keywords><keyword>otherbioactiveproducts</keyword><keyword>anticarcinogenicactivity,anticanceractivity</keyword></keywords><dates><year>2016</year></dates><urls></urls></record></Cite></EndNote>[30]。Wu等人从中国广东红树林来源真菌AspergillusversicolorHDN1009中分离得到6个新化合物versixanthonesA–F(82–87)。化合物82-87对多种肿瘤细胞系显示了细胞毒活性。化合物82-84对HL-60和K562有强选择性细胞毒性，IC50为2.6-18.2µM。化合物85-87对HL-60、K562、A549、H1975、803、HO-8910和HCT-116这7种肿瘤细胞系表现出广泛细胞毒性，IC50为0.7-14.0µMADDINEN.CITE<EndNote><Cite><Author>Wu</Author><Year>2015</Year><RecNum>139</RecNum><DisplayText><styleface="superscript">[31]</style></DisplayText><record><rec-number>139</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612754106">139</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Wu,Guangwei</author><author>Yu,Guihong</author><author>Kurtán,Tibor</author><author>Mándi,Attila</author><author>DehaiLi</author></authors></contributors><titles><title>VersixanthonesA-F,CytotoxicXanthone-ChromanoneDimersfromtheMarine-DerivedFungusAspergillusversicolorHDN1009</title><secondary-title>JournalofNaturalProducts</secondary-title></titles><periodical><full-title>JournalofNaturalProducts</full-title></periodical><pages>2691-8</pages><volume>78</volume><number>11</number><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>[31]。炎症是人体免疫反应的重要组成部分。海洋微生物是抗炎活性物质的重要来源。Ha等从一株海洋真菌Penicilliumsp.SF-5859发酵提取物中分离得化合物88-96。体外条件下，在脂多糖（LPS）刺激RAW264.7巨噬细胞中对这些化合物进行评估，化合物90-96能抑制脂多糖诱导产生的一氧化氮NO和前列腺素PGE2，IC50范围分别为1.9µM-18.1µM和2.8µM-18.7µMADDINEN.CITE<EndNote><Cite><Author>Tran</Author><Year>2017</Year><RecNum>140</RecNum><DisplayText><styleface="superscript">[32]</style></DisplayText><record><rec-number>140</rec-number><foreign-keys><keyapp="EN"db-id="zaszdwazbxt5s8ewxwapzrd8050z0e92d9d9"timestamp="1612754106">140</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Tran,Ha</author><author>Wonmin,Ko</author><author>Seung,Lee</author><author>Youn-Chul,Kim</author><author>Jae-Young,Son</author><author>Jae,Sohn</author><author>Joung,Yim</author><author>Hyuncheol,Oh</author></authors></contributors><titles><title>Anti-InflammatoryEffectsofCurvularin-TypeMetabolitesfromaMarine-DerivedFungalStrainPenicilliumsp.SF-5859inLipopolysaccharide-InducedRAW264.7Macrophages</title><