Pirmenol-hydrochloride-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEPirmenolhydrochloride(Standard)Cat.No.:HY-100795ARCASNo.:61477-94-9分子式:C₂₂H₃₁ClN₂O分子量:374.95作用靶点:mAChR;ReferenceStandards;PotassiumChannel作用通路:GPCR/GProtein;NeuronalSignaling;Others;MembraneTransporter/IonChannel储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Pirmenol(hydrochloride)(Standard)是Pirmenol(hydrochloride)(HY-100795A)的分析标准品。本产品用于研究及分析应用。Pirmenol((±)-Pirmenol)hydrochloride是一种具有口服活性的抗心律失常剂。Pirmenolhydrochloride通过阻断毒蕈碱性受体(mAchR)来抑制IK.ACh(IC50:0IC50&TargetIC50:0.1μM(IK.ACh)[1]REFERENCESWatanabeY,etal.Pirmenolinhibitsmuscarinicacetylcholinereceptor-operatedK+currentintheguineapigheart.EurJPharmacol.1997Oct29;338(1):71-4.SchardeinJL,etal.Preclinicaltoxicologystudieswithanewantiarrhythmicagent:Pirmenolhydrochloride(CI-845).ToxicolApplPharmacol.1980Nov;56(2):294-301.TSawanobori,etal.Electrophysiologicandantiarrhythmicactionsofpirmenolonrabbitandguineapigcardiacpreparations.JCardiovascPharmacol.1990Dec;16(6):975-83.TEMertz,etal.Pirmenolhydrochloride(CI-845):antiarrhythmicprofileincoronaryarteryligatedconsciousdogs.JCardiovascPharmacol.1980Sep-Oct;2(5):527-41.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:02