Pregnenolone-d6-3β-Hydroxy-5-pregnen-20-one-d-sub-6-sub-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEPregnenolone-d6Cat.No.:HY-B0151S3Synonyms:3β-Hydroxy-5-pregnen-20-one-d6分⼦式:C₂₁H₂₆D₆O₂分⼦量:322.51作⽤靶点:Isotope-LabeledCompounds;TRPChannel;Autophagy;CannabinoidReceptor;EndogenousMetabolite作⽤通路:Others;MembraneTransporter/IonChannel;Neuronal

Signaling;Autophagy;GPCR/GProtein;Metabolic

Enzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Pregnenolone-d6(3β-Hydroxy-5-pregnen-20-one-d6)Pregnenolone(HY-B0151)的氘代物。Pregnenolone(3β-Hydroxy-5-pregnen-20-one)⼀种功能强⼤的神经甾体，包括甾体酮在内的各种甾体激素的主前体。Pregnenolone⼤⿇素CB1受体的信号传导特异性抑制剂，抑制由CB1受体介导的四氢⼤⿇酚(THC)的作⽤。Pregnenolone可以保护⼤脑免受⼤⿇中毒。Pregnenolone也⼀种TRPM3通道激活剂，也可以弱激活TRPM1通道。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs[1].REFERENCES[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019Feb;53(2):211-216.[2].ValléeM,etal.Pregnenolonecanprotectthebrainfromcannabisintoxication.Science.2014Jan3;343(6166):94-8.[3].DucharmeN,etal.Braindistributionandbehavioraleffectsofprogesteroneandpregnenoloneafterintranasalorintravenousadministration.EurJPharmacol.2010Sep1641(2-3):128-34.[4].AlanShiels.TRPM3_miR-204:acomplexlocusforeyedevelopmentanddisease.HumGenomics.2020Feb1814(1):7.McePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;