Procainamide-d4-Procaine-amide-d-sub-4-sub-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEProcainamide-d4Cat.No.:HY-A0084ASSynonyms:Procaineamide-d4;SP100-d4分⼦式:C₁₃H₁₇D₄N₃O分⼦量:239.35作⽤靶点:Isotope-LabeledCompounds;PotassiumChannel;DNAMethyltransferase作⽤通路:Others;MembraneTransporter/IonChannel;Epigenetics储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Procainamide-d4(Procaineamide-d4)氘代标记的Procainamide(HY-A0084A)。Procainamide(Procaineamide)⼀种特异性强效的DNA甲转移酶1(DNMT1)抑制剂，通过对肿瘤抑制因去甲化来重新激活肿瘤抑制因⼦的表达。Procainamide可诱导各种类型的细胞空泡化，降低细胞的增殖和迁移。Procainamide通过激活钾通道(potassiumchannel)来松弛⽓管平滑肌。Procainamide可⽤于癌症和⼼律失常的研究。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].LeeBH,etal.ProcainamideisaspecificinhibitorofDNAmethyltransferase1.JBiolChem.2005;280(49):40749-40756.[2].PritchardB,etal.Procainamide.[Updated2021Aug8].In:StatPearls[Internet].TreasureIsland(FL):StatPearlsPublishing;2022Jan-.[3].GardnerI,etal.Acomparisonofthecovalentbindingofclozapine,procainamide,andvesnarinonetohumanneutrophilsinvitroandrattissuesinvitroandinvivo[J].Chemicalresearchintoxicology,2005,18(9):1384-1394.[4].NakaharaT,etal.InvolvementofK+channelinprocainamide-inducedrelaxationofbovinetrachealsmoothmuscle[J].Europeanjournalofpharmacology,2000,402(1-2):143-149.[5].MorissetteG,etal.Massivecellvacuolizationinducedbyorganicaminessuchasprocainamide[J].JournalofPharmacologyandExperimentalTherapeutics,2004,310(1):395-406.[6].Segura-PachecoB,etal.Reactivationoftumorsuppressorgenesbythecardiovasculardrugshydralazineandprocainamideandtheirpotentialuseincancertherapy[J].ClinicalCancerResearch,2003,9(5):1596-1603.McePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly