Q-VD-OPh-GMP-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEQ-VD-OPh(GMP)Cat.No.:HY-12305GCASNo.:1135695-98-5分⼦式:C₂₆H₂₅F₂N₃O₆分⼦量:513.49作⽤靶点:Caspase;HIV作⽤通路:Apoptosis;Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Q-VD-OPh(GMP)GMP级别的Q-VD-OPh(HY-12305)。GMP级别的⼩分⼦可⽤做细胞疗法中的辅助试剂。Q-VD-OPh⼀种不可逆的泛胱天蛋⽩酶(caspase)抑制剂，具有⾼效的抗凋亡能⼒。抑制胱天蛋⽩酶7的IC50值别为48nM，抑制胱天蛋⽩酶1，3，8，9，10，12的IC50值在25-400nM之间。Q-VD-OPh可抑制HIV感染。Q-VD-OPh能透过⾎脑屏障。体外研究Q-VD-OPhisapotentinhibitorofcaspase-7withanIC50of48nMutilizingacell-freeassayconsistingofhumanrecombinantcaspase-7,Q-VD-OPh,andthesubstrateAMC-DEVD-pNa[1].Q-VD-OPhfullyinhibitscaspase-3and-7activityat0.05μM.Caspase-8isalsoinhibitedatlowQ-VD-OPhconcentrations.ThecleavageofPARP-1isfullypreventedat10μMQ-VD-OPh.DNAfragmentationanddisruptionofthecellmembranefunctionalityarebothpreventedat2μMQ-VD-OPh[2].Q-VD-OPhissignificantlymoreeffectiveinpreventingapoptosisthanthewidelyusedinhibitors,ZVAD-fmkandBoc-D-fmk,andisalsoequallyeffectiveinpreventingapoptosismediatedbythethreemajorapoptoticpathways,caspase9/3,caspase8/10,andcaspase12.Q-VD-OPhisnottoxictocellsevenatextremelyhighconcentrations[3].QVDisalsoabletoincreasetheexpressionofdifferentiationmarkersinacutemyeloidleukemia(AmL)blasts.QVDaloneorcombinedwithVDDsincreasesdifferentiationandHPK1-cJunsignalinginAmLcellcontext-dependentmanner[4].体内研究ChronictreatmentwithQ-VD-OPhpreventscaspase-7activationandlimitsthepathologicalchangesassociatedwithtau,includingcaspasecleavage.Q-VD-OPhcouldbeapotentialtherapeuticcompoundforthetreatmentofAlzheimer'sdisease[1].户使⽤本产品发表的科研⽂献1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE•Nature.2025Apr;640(8060):1062-1071.•Nature.2023Mar;615(7950):158-167.•CancerCell.2024May13;42(5):850-868.e9.•Immunity.2024Dec10;57(12):2737-2754.e12.•CellMolImmunol.2025Nov25.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].LaforgeM,etal.Theanti-caspaseinhibitorQ-VD-OPHpreventsAIDSdiseaseprogressioninSIV-infectedrhesusmacaques.JClinInvest.2018Apr2;128(4):1627-1640.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearc