Rac-Atomoxetine-hydrochloride-Rac-Tomoxetine-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(Rac)-AtomoxetinehydrochlorideCat.No.:HY-107370ACASNo.:82857-40-7Synonyms:(Rac)-Tomoxetinehydrochloride;(Rac)-LY139603分⼦式:C₁₇H₂₂ClNO分⼦量:291.82作⽤靶点:SerotoninTransporter;SodiumChannel作⽤通路:NeuronalSignaling;MembraneTransporter/IonChannel储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性(Rac)-Atomoxetinehydrochloride((Rac)-Tomoxetine(hydrochloride);(Rac)-LY139603)Atomoxetinehydrochloride(HY-17385)的外消旋体。Atomoxetinehydrochloride⼀种选择性去甲肾上腺素再摄取抑制剂(noradrenalinereuptake)，去甲肾上腺素(NE)、5-羟⾊胺(5-HT)和多巴胺(DA)转运体的Ki值分别为5、77和1451nM。Atomoxetinehydrochloride可以增加PFC中DAEX和NEEX，从⽽增强⼉茶酚胺能神经传递。Atomoxetinehydrochloride⼀种有效的Na+通道阻断剂(VGSCs)。Atomoxetinehydrochloride可⽤于注意⼒缺陷多动障碍(ADHD)的研究。REFERENCES[1].TurnerM,et,al.Effectsofatomoxetineonlocomotoractivityandimpulsivityinthespontaneouslyhypertensiverat.BehavBrainRes.2013Apr15;243:28-37.[2].FöhrKJ,et,al.BlockofVoltage-GatedSodiumChannelsbyAtomoxetineinaState-andUse-dependentManner.FrontPharmacol.2021Feb25;12:622489.[3].BymasterFP,et,al.Atomoxetineincreasesextracellularlevelsofnorepinephrineanddopamineinprefrontalcortexofrat:apotentialmechanismforefficacyinattentiondeficit/hyperactivitydisorder.Neuropsychopharmacology.2002Nov;27(5):699-711.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792