Razuprotafib-sodium-AKB-9778-sodium-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemERazuprotafibsodiumCat.No.:HY-109041ACASNo.:1809275-69-1Synonyms:AKB-9778sodium分⼦式:C₂₆H₂₅N₄NaO₆S₃分⼦量:608.68作⽤靶点:Phosphatase;Tie作⽤通路:MetabolicEnzyme/Protease;ProteinTyrosineKinase/RTK储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Razuprotafib(AKB-9778)sodiumVE-PTP(HPTPη)催化活性的有效选择性抑制剂(IC50=17pM)，促进TIE2活化，增强ANG1诱导的TIE2活化，并刺激TIE2通路中信号分⼦的磷酸化，包括AKT、eNOS和ERK。Razuprotafibsodium抑制结构相关磷酸酶PTP1B，IC50为780nM。除HPTPη(IC50=36pM)和HPTPγ(100pM)外，Razuprotafibsodium对VE-PTP具有良好的选择性。体外研究Razuprotafib(AKB-9778)sodiumpromotesTIE2phosphorylationandactivationofdownstreamsignalinginHUVECsandenhancesangiopoietin-inducedTIE2phosphorylation[1].体内研究Razuprotafibsodium(20mg/kg;s.c.)promotesphosphorylationofTIE2inretinalendothelialcellsinvivo[1].Razuprotafibsodium(10-20mg/kg;s.c.;twicedailyfor7days)suppressessubretinalneovascularization(NV)[1].户使⽤本产品发表的科研⽂献•ExpMolMed.2023Feb;55(2):470-484.•IntJMolSci.2025Mar25;26(7):3000.•IntImmunopharmacol.2025Jan28:148:114133.•ResearchSquarePrint.August19th,2022.Seemorecustomervalidationsonwww.MedChemEREFERENCES1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[1].ShenJ,etal.TargetingVE-PTPactivatesTIE2andstabilizestheocularvasculature.JClinInvest.2014;124(10):4564-4576.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>