rel-Latanoprost-acid-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemErel-LatanoprostacidCat.No.:HY-113756BCASNo.:2699713-95-4分⼦式:C₂₃H₃₄O₅分⼦量:390.51作⽤靶点:DrugDerivative;ProstaglandinReceptor作⽤通路:Others;GPCR/GProtein储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性rel-LatanoprostacidLatanoprostacid(HY-113756A)的⼀种相对构型。Latanoprostacid前列腺素(PG)F2α的类似物，选择性的前列腺素受体FP激动剂，FP可以特异性激活FP-PG受体。Latanoprostacid通过抑制ERK，AKT，JNK和p38级联反应，继⽽沿c-fos/NFATc1通路抑制RANKL诱导的破⾻细胞⽣成和功能。Latanoprostacid⼀种可降低眼内压⼒的活性分⼦。IC50&TargetFP体外研究Latanoprostacid(10-20μM;24h)reducesheproteinexpressionsofc-fosandNFATc1[1].Latanoprostacid(10μMwith50ng/mlRANKL)significantlyinhibitsERK,p38,AKTandJNK[1].Latanoprostacid(10-20μM)significantlyinhibitsthematureosteoclastformation[1].体内研究Latanoprostacid(20mg/kg;i.p.;onceadayfor7days)notablypreventsLPS(HY-D1056)-inducedbonedestruction[1].REFERENCES[1].WeinrebRN,etal.Effectsofprostaglandinsontheaqueoushumoroutflowpathways.SurvOphthalmol.2002Aug;47Suppl1:S53-64.[2].XuX,etal.Thepreventionoflatanoprostonosteoclastgenesisinvitroandlipopolysaccharide-inducedmurinecalvariaosteolysisinvivo.JCellBiochem.2018Jun;119(6):4680-4691.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:0