rel-Talmapimod-hydrochloride-rel-SCIO-469-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemErel-TalmapimodhydrochlorideCat.No.:HY-10406BCASNo.:879132-01-1Synonyms:rel-SCIO-469hydrochloride分⼦式:C₂₇H₃₁Cl₂FN₄O₃分⼦量:549.46作⽤靶点:p38MAPK;TNFReceptor;InterleukinRelated;VEGFR;Apoptosis作⽤通路:MAPK/ERKPathway;Apoptosis;Immunology/Inflammation;ProteinTyrosineKinase/RTK储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性rel-Talmapimod(rel-SCIO-469)hydrochloride⼀种⼝服有效的、选择性的p38αMAPK抑制剂，其IC50为9nM。rel-Talmapimodhydrochloride通过抑制p38αMAPK通路，抑制炎症因⼦(如TNFα、IL-1β、IL-6和VEGF)分泌，抑制⾎管⽣成和破⾻细胞活化。rel-Talmapimodhydrochloride抑制多发性⾻髓瘤细胞⽣长并诱导凋亡(apoptosis)。rel-Talmapimodhydrochloride可⽤于研究多种⾎液恶性肿瘤(如多发性⾻髓瘤、⾻髓增⽣异常综合征)。IC50&Targetp38αMAPKp38βMAPKIL-6IL-1β9nM(IC50)90nM(IC50)户使⽤本产品发表的科研⽂献•Cell.2020Aug6;182(3):685-712.e19.•SciTranslMed.2018Jul18;10(450):eaaq1093.•CellBiolToxicol.2021Aug;37(4):515-529.Seemorecustomervalidationsonwww.MedChemEREFERENCES1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[1].HideshimaTetal.p38MAPKinhibitionenhancesPS-341(bortezomib)-inducedcytotoxicityagainstmultiplemyelomacells.Oncogene.2004Nov18,23(54),8766-76.[2].NavasT,etal.Inhibitionofp38alphaMAPKdisruptsthepathologicalloopofproinflammatoryfactorproductioninthemyelodysplasticsyndromebonemarrowmicroenvironment.LeukLymphoma.2008Oct;49(10):1963-75.[3].VanderkerkenKetal.Inhibitionofp38alphamitogen-activatedproteinkinasepreventsthedevelopmentofosteolyticbonedisease,reducestumorburden,andincreasessurvivalinmurinemodelsofmultiplemyeloma.CancerRes.2007May15;67(10):4572-7.[4].MedicherlaS,etal.p38alpha-selectiveMAPkinaseinhibitorreducestumorgrowthinmousexenograftmodelsofmultiplemyeloma.AnticancerRes.2008Nov-Dec;28(6A):3827-33.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-8