YE6144-free-base-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEYE6144freebaseCat.No.:HY-150095ACASNo.:3065657-01-1分⼦式:C₂₁H₂₆FN₇O分⼦量:411.48作⽤靶点:IFNAR作⽤通路:Immunology/Inflammation储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性YE6144freebase⼀种选择性原型⼲扰素调节因⼦5(IRF5)抑制剂。YE6144freebase在系统性红斑狼疮(SLE)⼩⿏模型中能够抑制疾病进程，并且在维持缓解⽅尤为有效。YE6144freebase可⽤于SLE研究[1]。IC50&TargetIRF5体外研究YE6144(1or3μM;30min)freebaseinhibitsthephosphorylationofIRF5inbothhumanPBMCsandmousesplenocytes[1].YE6144(0-10μM;30min)freebaseinhibitstheproductionoftypeIIFNswithanIC50ofapproximately0.09ꢀμMinhumanHCPBMCs[1].WesternBlotAnalysis[1]CellLine:HumanHCPBMCsandmouseWTsplenocytesConcentration:1μM(PBMCs)and3μM(splenocytes)IncubationTime:30minResult:InhibitedthephosphorylationofIRF5.RT-PCR[1]CellLine:MouseWTsplenocytesConcentration:3μM1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEIncubationTime:30minResult:InductionoftypeIIFNgenes,Ifnb1andIfnastimulatedbyTLR7ligandsorTLR9ligandswasremarkablyweakened.体内研究YE6144(40.0mg/kg;s.c.;once)freebasesuppressestheprogressionofmousesystemiclupuserythematosus[1].AnimalModel:NZB/WF1mousemodelofsystemiclupuserythematosus(SLE)[1]Dosage:40.0ꢀmg/kgAdministration:s.c.;onceResult:Suppressedtheexacerbationofautoantibodyproduction.Splenomegalyandrenaldysfunctionwerealsosuppressedbythetreatmentafterdiseaseonset.户使⽤本产品发表的科研⽂献•bioRxiv.2024August19.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].BanT,etal.GeneticandchemicalinhibitionofIRF5suppressespre-existingmouselupus-likedisease.NatCommun.2021Jul19;12(1):4379.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37