Z-IETD-FMK-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEZ-IETD-FMK(Standard)Cat.No.:HY-101297RCASNo.:210344-98-2分⼦式:C₃₀H₄₃FN₄O₁₁分⼦量:654.68作⽤靶点:Caspase;ReferenceStandards作⽤通路:Apoptosis;Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Z-IETD-FMK(Standard)Z-IETD-FMK(HY-101297)的分析标准品。本产品⽤于研究及分析应⽤。Z-IETD-FMK(Z-IE(OMe)TD(OMe)-FMK)⼀种具有细胞渗透作⽤的选择性caspase-8抑制剂[1]。Z-IETD-FMK也颗粒酶B(granzymeB)抑制剂[5]。REFERENCES[1].CowburnAS,etal.z-VAD-fmkaugmentationofTNFalpha-stimulatedneutrophilapoptosisiscompoundspecificanddoesnotinvolvethegenerationofreactiveoxygenspecies.[2].LawrenceCP,etal.SuppressionofhumanTcellproliferationbythecaspaseinhibitors,z-VAD-FMKandz-IETD-FMKisindependentoftheircaspaseinhibitionproperties.ToxicolApplPharmacol.2012Nov15;265(1):103-12.[3].TezelG,etal.Inhibitionofcaspaseactivityinretinalcellapoptosisinducedbyvariousstimuliinvitro.InvestOphthalmolVisSci.1999Oct;40(11):2660-7.[4].TerlizziM,etal.Pharmacologicalinhibitionofcaspase-8limitslungtumouroutgrowth.BrJPharmacol.2015Aug;172(15):3917-28.[5].YangJ,etal.GranzymeBIsanEssentialMediatorinCD8+TCellKillingofTheileriaparva-InfectedCells.InfectImmun.2018Dec19;87(1).pii:e00386-18.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: