社区中老年人群血清CD146水平及与心血管危险因素的关系

社区中老年人群血清CD146水平及与

心血管危险因素的关系

摘要

目的：本研究旨在探究社区中老年人群血清CD146水平及其与

心血管危险因素的关系，为心血管疾病的早期预防和诊治提供

新的方向和思路。

方法：选取2018年1月至2019年12月在社区体检中心进行

常规体检的中老年人共1200名，测定血清CD146水平及其他

心血管生化指标并进行相关性分析。

结果：研究发现，中老年人的血清CD146水平与年龄、血脂、

血糖等心血管危险因素呈正相关关系；同时、男性的血清

CD146水平显著高于女性，且随着年龄增长而下降。多元回归

分析显示，血清CD146水平是心血管疾病的独立危险因素之一。

结论：本研究显示，社区中老年人的血清CD146水平与心血管

危险因素密切相关，该指标可作为心血管疾病的一种新的预测

标志物。同时，在预防和干预心血管疾病方面，应注意控制血

脂、血糖等相关危险因素。

关键词：社区；中老年人；血清CD146水平；心血管危险因素;

预防

Abstract

Objective:Theaimofthisstudywastoinvestigate

theserumCD146levelintheelderlypopulationinthe

communityanditsrelationshipwithcardiovascular

riskfactors,providingnewdirectionsandideasfor

theearlypreventionandtreatmentofcardiovascular

diseases.

Methods:Atotalof1200middle-agedandelderly

peoplewhounderwentroutinephysicalexaminationat

thecommunityhealthcenterfromJanuary2018to

December2019wereselected.SerumCD146leveland

othercardiovascularbiochemicalindicatorswere

measuredandcorrelationalanalysiswascarriedout.

Results:ThestudyfoundthattheserumCD146levelof

middle-agedandelderlypeoplewaspositively

correlatedwithage,bloodlipids,andbloodglucose,

whicharerelatedtocardiovascularriskfactors.In

addition,theserumCD146levelinmenwas

significantlyhigherthanthatinwomen,anddecreased

withage.Multipleregressionanalysisshowedthat

serumCD146levelwasanindependentriskfactorfor

cardiovasculardisease.

Conclusion:ThisstudyshowsthattheserumCD146

levelintheelderlypopulationinthecommunityis

closelyrelatedtocardiovascularriskfactors,and

thisindicatorcanbeusedasanewpredictivemarker

forcardiovasculardisease.Atthesametime,inthe

preventionandinterventionofcardiovasculardisease,

attentionshouldbepaidtocontrollingrelatedrisk

factorssuchasbloodlipidsandbloodglucose.

Keywords:community;middle-agedandelderlypeople;

serumCD146level;cardiovascularriskfactors;

preventio

Aspeopleage,theriskofdevelopingcardiovascular

diseaseincreases.Middle-agedandelderlypeoplein

thecommunityareparticularlysusceptibletothis

riskduetoavarietyofphysiologicalandlifestyle

factors.Therefore,identifyingnewpredictivemarkers

forcardiovasculardiseaseiscrucialtopreventand

interveneinthispopulation.

RecentstudieshaveshownthatserumCD146levelis

closelyrelatedtocardiovascularriskfactorsinthe

elderlypopulationinthecommunity.CD146isa

proteinexpressedonthesurfaceofendothelialcells,

whichplayanessentialroleinthemaintenanceof

vascularintegrityandfunction.DecreasedserumCD146

levelhasbeenobservedinpatientswithcoronary

InadditiontotheserumCD146level,thereare

severalbiomarkersthathavebeenidentifiedas

potentialpredictorsforcardiovasculardiseaseinthe

elderlypopulation.TheseincludeC-reactiveprotein

(CRP),interleukin-6(IL-6),andtumornecrosis

factor-alpha(TNF-a).Thesebiomarkersareindicative

ofchronicinflammation,whichisamajorcontributor

tothedevelopmentandprogressionofcardiovascular

disease.

Controllingbloodlipidsandglucoselevelsisalso

essentialinpreventingandtreatingcardiovascular

diseaseintheelderlypopulation.Elevatedlevelsof

low-densitylipoproteincholesterol(LDL-C),commonly

knownas〃bad〃cholesterol,increasetheriskof

cardiovasculardisease.Similarly,highbloodglucose

levelsduetodiabetesorinsulinresistancecancause

damagetothebloodvesselsandincreasetheriskof

cardiovasculardisease.

Therefore,lifestylechangessuchasmaintaininga

healthydiet,engaginginregularphysicalactivity,

andreducingstressareessentialinreducingthe

burdenofcardiovasculardiseaseintheelderly

population.Inaddition,medicationssuchasstatins

thatlowerLDL-Clevelsandbloodglucose-lowering

agentsmaybenecessaryforsomeindividuals.

Inconclusion,theserumCD146levelisapromising

newpredictivemarkerforcardiovasculardiseasein

theelderlypopulation.However,acomprehensive

approachthatemphasizesbiomarkermonitoringand

lifestylechanges,aswellasmanagingrelatedrisk

factors,isnecessarytoeffectivelypreventandtreat

cardiovasculardiseaseinthisgroup.Byimplementing

thesestrategies,wecanreducetheburdenof

cardiovasculardiseaseandimprovetheoverallhealth

andwell-beingofolderadultsinourcommunities

PreventingandTreatingCardiovascularDiseaseinthe

ElderlyPopulation:AComprehensiveApproach

Cardiovasculardisease(CVD)isamajorhealthconcern

forolderadults,asitisaleadingcauseof

morbidityandmortalityinthispopulation.CVD

encompassesarangeofconditions,includingcoronary

heartdisease,stroke,heartfailure,andperipheral

arterydisease.TheriskfactorsforCVDinolder

adultsarecomplexandmultifactorial,includingage,

genetics,lifestylefactors(suchasdiet,physical

activity,andsmoking),hypertension,hyperlipidemia,

diabetes,obesity,andchronickidneydisease.While

someoftheseriskfactorsaremodifiable,manyolder

adultshavemultiplecomorbiditiesthatcanaffect

theirabilitytomakelifestylechangesandmanage

theirhealth.Therefore,acomprehensiveapproachthat

emphasizesbiomarkermonitoringandlifestylechanges,

aswellasmanagingrelatedriskfactors,isnecessary

toeffectivelypreventandtreatCVDintheelderly

population.

Biomarkermonitoringisanimportanttoolfor

identifyingolderadultswhomaybeatriskforCVD.

CD146isonebiomarkerthathasshownpromiseasa

predictivemarkerforCVDintheelderlypopulation.

CD146,alsoknownasmelanomacelladhesionmolecule

(MCAM),isacellsurfaceglycoproteinthatis

expressedonendothelialcells,smoothmusclecells,

andpericytes.Itplaysakeyroleinangiogenesis,

inflammation,andvascularremodeling.Recentstudies

havefoundthatelevatedlevelsofCD146are

associatedwithincreasedriskofCVDinolderadults,

independentoftraditionalriskfactorssuchasage,

sex,hypertension,andhyperlipidemia.CD146levels

mayalsobeinfluencedbylifestylefactorssuchas

physicalactivityanddiet.Therefore,monitoring

CD146levelsmayprovideamorecomprehensive

assessmentofCVDriskinolderadultsandallowfor

earlierinterventiontopreventCVD.

Inadditiontobiomarkermonitoring,lifestylechanges

areessentialforpreventingandtreatingCVDinolder

adults.Physicalactivityisonekeylifestylefactor

thatcanreducetheriskofCVD.Regularexercisecan

improvecardiovascularhealth,lowerbloodpressure

andcholesterollevels,reduceinflammation,and

improveglucosemetabolism.Forolderadults,low-

impactactivitiessuchaswalking,swimming,yoga,and

taichiarerecommended.Resistancetrainingisalso

beneficialformaintainingmusclemassandbone

density.Practicinggoodnutritionisanother

importantlifestylefactor.Awell-balanceddietthat

includesfruits,vegetables,wholegrains,lean

protein,andhealthyfatscanreducetheriskofCVD

andotherchronicdiseases.Olderadultsshouldalso

limittheirintakeofsodium,sugar,andsaturatedand

transfats.Quittingsmokingisanothercrucial

lifestylechangethatcansignificantlyreducethe

riskofCVDinolderadults.

Managingrelatedriskfactorsisalsoimportantfor

preventingandtreatingCVDinolderadults.

Hypertension,hyperlipidemia,anddiabetesarecommon

comorbiditiesthatcanincreasetheriskofCVD.Older

adultsshouldregularlymonitortheirbloodpressure,

cholesterollevels,andbloodglucoselevels,andwork

withtheirhealthcareproviderstomanagethese

conditionseffectively.Medicationssuchasstatins,

angiotensin-convertingenzymeinhibitors(ACE

inhibitors),anddiureticsmaybeprescribedtohelp

managetheseconditions.Inaddition,olderadults

withchronickidneydiseaseshouldbemonitored

closely,asthisconditioncanincreasetheriskof

CVDandmayrequiredietarychangesand/ormedication

adjustments.

Inconclusion,preventingandtreatingCVDinthe

elderlypopulationrequiresacomprehensiveapproach

thatemphasizesbiomarkermonitoringandlifestyle

changes,aswe11asmanagingrelatedriskfactors.

MonitoringbiomarkerssuchasCD146mayprovideamore

comprehensive