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MeKinsey

HealthInstitute

Thefuture

ofhealthyliving

A$16.4trillionopportunity

NewMcKinseyHealthInstituteanalysisfindsthataddressingmodifiableriskfactorscould

add12yearstohealthylifeexpectancyatbirthand

addnearly9percenttotheglobaleconomyby2050.

CONTENTS

Thehealthyliving

opportunityis

enormous-andmostofwhatshapesitsitsoutsidehealthcare3

Sizingcountry-

specificriskfactorsshowswhereto

focusforthe

greatesthealthandeconomicvalue6

Adisciplined

deliveryblueprinttoenablehealthylivingatscale11

Whyhealthylivinghasnotscaled

yet,andhowtochangethat14

Thefutureofhealthyliving:A$16.4trillionopportunityiii

acedwithagingpopulationsandagrowingburdenofpreventablediseases,governmentofficialshaveatransformativeopportunitytocreatehealthier,moreprosperoussocieties.Healthylivingisnolongeronlyasocialobjective;itisaneconomicimperativeandacross-governmentdeliverychallenge.

Modifiablehealthriskfactorsrepresentoneofthelargestuntappedopportunitiesforgovernmentstoimprovepopulationhealthwhilestrengtheningeconomicperformance.In2050,eliminatingbehavioral,metabolic,andenvironmentalriskfactorscouldadd12yearsoflifeexpectancyatbirthandgenerateanestimated$16.4trillioninannualGDPupliftglobally,accordingtoaMcKinseyHealthInstitute(MHI)analysis.Thisisequivalenttonearly9percentoftotalGDPin2050(formore,seesidebar"Terminology").

Somegovernmentsarealreadymakinghealthylivingastrategicprioritytocapturethehumanandeconomicbenefitsofhealthierlifespans.InAbuDhabi,forexample,ahealthy-livingstrategydemonstrateshowgovernmentscouldmobilizeabroad,cross-governmentagendaforhealthyliving.Ashealthylongevityincreasinglybecomesapriorityaroundtheworld,scalingprogresswillrequiregovernmentstoleadactionacrossthesectorsthatshapehealth,supportedby

strongerevidence,tools,andmeaningfulopportunitiestolearnfromothers.

Thisreportquantifiestheopportunity,highlightslessonsfromAbuDhabiandothergeographies,laysoutapracticaldeliveryplaybookforgovernments,andexploreshownewglobal

collaborationcanhelptoaccelerateprogress.

Healthylivingisnolongeronlyasocialobjective;itisaneconomicimperativeandacross-governmentdeliverychallenge.

Thefutureofhealthyliving:A$16.4trillionopportunity1

Thefutureofhealthyliving:A$16.4tillionopportunity2

Sidebar

Terminology

TermDefinition

Disability-adjustedlifeyear(DALY)

Thesumofyearslostduetoprematuredeath(YLLs)andyearslivedwithdisability(YLDs).OneDALYequalsonelostyearofhealthylife.

Diseaseburden

Theimpactofhealthlossattributabletodiseasesandinjuries,encompassingbothprematuremortalityandnonfatalhealthloss.

Driverofhealth

Acontributorthatinfluencesanindividual'shealthandhealthoutcomesandcanbeshapedthroughindividualchoicesand/orstructuralandenvironmentalconditions.

Healthequity

Theabsenceofavoidable,unfair,orremediabledifferencesinhealthoutcomesacrossgroupsofpeople.

Healthylifeexpectancy

Thenumberofyearsthatapersonatagivenagecanexpecttoliveingoodhealth,assumingratesofmortalityanddisabilityremainunchanged.

Healthylongevity

Theabilitytolivelongerwhilespendingmoreofthoseyearsingoodhealth,withpreservedfunction,well-being,andindependence.

Metabolichealth

Thebody'sabilitytoefficientlyproduce,regulate,anduseenergytosustaindaily

function,whilesupportingthehealthofkeysystemsoverthelifecourse,includingthecardiovascular,renal,andhepaticsystems.

Modifiableriskfactor

Ariskfactorthatcanbechangedthroughbehavior,clinicalcare,policy,environment,or

system-levelintervention.Anattribute,behavior,exposure,orotherfactorthatiscausallyassociatedwiththeprobabilityofadiseaseorinjuryandisamendabletomodification

throughbehavior,clinicalcare,policy,environment,orsystem-levelintervention.

Noncommunicabledisease(NCD)

Adiseasethatistypicallynoninfectiousinoriginandisnottransmittedfromoneindividualtoanother.MajorNCDsincludecardiovasculardiseases,cancer,chronicrespiratory

diseases,anddiabetes.

Populationhealthintelligence

Theuseofintegrateddataandanalyticstogenerateinsightsintopopulationhealthneeds,identifyprioritygroups,informtailoredinterventions,andtrackoutcomesovertime.

Riskfactor

Ameasurableexposure,condition,orbehaviorthatincreasesthelikelihoodorseverityofpoorhealth.

Yearslivedwithdisability(YLD)

Yearslivedwithanyshort-termorlong-termhealthloss.

Thefutureofhealthyliving:A$16.4trillionopportunity3

Chapter1

Thehealthylivingopportunityisenormous—andmostofwhat

shapesitsitsoutsidehealthcare

Healthylivingmeanstwothings:thrivingingoodhealthtodayandlivinginawaythatalso

maximizestheyearsofgreathealthstillocome.Peoplewhoarethrivinghavestrongphysical,mental,social,andspiritualhealth.Theyhavehighlevelsofenergy,resilience,connection,

andasenseofpurposeacrossthelifecourse.Overtime,healthylivingisthefoundationforhealthylongevity.

Unfortunately,asMHIhaspreviouslyexplored,healthylivingremainsoutofreachforlargepartsofthepopulation.Globally,peoplespendroughlyhalfoftheirlivesinless-than-greathealth,

includingyearsmarkedbypain,limitedmobility,impairedsenses,cognitivedecline,orloss

ofindependence.'Thereasonsarewidespread:Oneinthreeadultsgloballydoesnotachieve

recommendedphysicalactivitylevels,nearlytheentireglobalpopulationisexposedtoair

pollutionaboveWorldHealthOrganizationguidelinelimits,andintheUnitedStates,morethan

nineintenadultsareinsuboptimalcardiometabolichealth.2Thismeanshealthylivingcannotbetreatedasanichewellnessgoal,butinsteadasapopulation-scalechallengeshapedbyeverydayenvironments,behaviors,andsystems.

1"Addingyearstolifeandlifetoyears,"McKinseyHealthInstitute,March29,2022.

2"Nearly1.8billionadultsatriskofdiseasefromnotdoingenoughphysicalactivity"WorldHealthOrganization(WHO),

June24,2024;"Billionsofpeoplestillbreatheunhealthyair:NewWHOdata,"WorldHealthOrganization,April4,2022;MeghanO'Hearnetal.,"TrendsanddisparitiesincardiometabolichealthamongU.S.adults,1999-2018,"JoumaloftheAmerican

CollegeofCardiology,July2022,Volume80,Number2.

Thefutureofhealthyliving:A$16.4trillionopportunity4

Goodhealthisoftenseenasanindividualdecision.Yetthisunderestimateshowelementsofdailylife-rangingfromaccesstohealthyfoodtosafewalkableneighborhoodstoadequate

homeheatingandcooling-profoundlyaffectone'shealth.Everysectorandindustryhasaroletoplayinachievinghealthylivingforall,andgovernmentscanhaveacriticallyimportantroleinsettingaspirationsandleadingthechange.

Therearesixreasonswhygovernmentsmayconsidermakinghealthylivinganoverallpriority:

-Individuals'healthcouldsubstantiallyimprove.Eliminatingmodifiableriskfactors

couldincreaseglobalhealthylifeexpectancyatbirthby12yearsin2050,accordingtoMHlanalysis.³Foranindividual,thatmeansmoreyearsofhealthylifeandmoreyearsofproductivitywithoutadditionalsocialorhealthcaresupport.

一Theeconomicopportunityissubstantial.Globally,MHIfindsthatthetotaleconomicimpactofinvestinginhealthylivingin2050couldamounttocloseto9percentofprojectedGDP,or$16.4trillion.Withanopportunityofthatmagnitude,healthylivingisaprimarycandidateforcross-sectorinvestmentatanationalscale.

-Thecostofinactionistoohightoignore.Thecurrentforecastforglobalhealthcarespendingin2050isnearlytwotimeshigherthaninafuturewheregovernmentsacttoenablehealthylivingandmodifiableriskfactorsareeliminated.4Severaladvancedhealthsystems-includinginFranceandtheUnitedStates-faceprojectedfiscalpressuresandshortfallsdriveninpartbyrisinghealthcarecosts.5Withoutreducingthedemandforhealthcarethroughpopulation-levelhealthyliving,theburdenofpreventablediseasecouldpushspendingbeyondwhat

governmentscansustain,compoundingpressureonproductivity,dependencyratios,andpublicfinances.

-Mosthealthdriverssitoutsidehealthcare.Ofthe23modifiabledriversofhealth(Exhibit1),19sitoutsideoftheformalhealthcaresystem,6makingthecaseforactionacrosssectors,governmentdepartments,andtop-of-governmentleaders.Byreinforcinghealthdrivers

throughawhole-of-societyhealthylivingagenda,governmentscanreduceriskfactorsforpoorhealth,promotehealthylongevity,andgeneratesubstantialeconomicreturns.

-Peoplewantit.Ina2025McKinseyFutureofWellnesssurveyofmorethan9,000US

respondents,upto60percentofrespondentsreportedthathealthyagingisatoporvery

importantpriority.Peopleassociatehealthyagingwithabroadsetofbenefits:livinglonger,maintainingcognitiveandphysicalfunction,independence,energy,andpreventingchronicdisease.Thisinterestspansgenerations,thoughprioritiesdiffer-youngergenerations

emphasizehealth,sleep,andnutrition,whileoldergenerationsfocusmoreonindependence,socialconnection,andpurpose.?Importantlyforgovernments,manyrespondentsreportthattheirwellnessneedsremainunmet.Leaderscanaddressthisstrongpublicdemandtobuildsupportforambitioushealthy-livingagendas,enablingsustainedimplementationoverthe

longterm.

一Thereisnowawindowofopportunity.Theemergenceoftherapiesusingglucagon-like

peptide-1(GLP-1)drugshascatalyzedanewlevelofattentiontoobesityandmetabolic

health,bringingtheseissuesmorefirmlyontotheagendasofgovernments,healthsystems,

3Aditionalhealthyyearsoflifegainedfromfulliskelimination,calculatedasthedifferencebetweenforecastedhealthylifeexpectancy(HALE)atbirthundereliminationofallmajorriskfactorsandbaselineHALE,usingforecastsfromtheInstituteforHealthMetricsandEvaluation.

4Estimateassumeshealthcarespendingscalesroughlylinearlywithchangesindiseaseburdenasmeasuredindisability-

adjustedlifeyears(DALYs).Thisisasimplifyingassumptionsincespendingisdrivenbyprices,caremix,andsystemoverheadasmuchasbyburden,andthecostofavertingortreatingoneDALYvarieswidelybyconditionandintervention.

5Thelong-termbudgetoutlook:2025to2055,CongressionalBudgetOffice,March2025;Fiscalsustainabilityofhealthsystems,OECD,January11,2024.

6LarsHartensteinandTomLatkovic,"Thesecrettogreathealth?Escapingthehealthcarematrix,"McKinseyHealthInstitute,December20,2022.

7"The$2tillionglobalwellnessmarketgetsamillennialandGenZglow-up,"McKinsey,May29,2025;"Ageisjustanumber:Howolderadultsviewhealthyaging,"McKinseyHealthInstitute,May22,2023.

Thefutureofhealthyliving:A$16.4trillionopportunity5

Exhibit1

Healthisshapedby23drivers,mostofwhichsitoutsidetraditionalhealthcaresystems.

Driversofhealth,bydimension¹

HealthcaresystemOutsideofhealthcaresystem

Spiritual

Physicel

Physicalinputs

·Diet

·Supplementation

·Substanceuse

Helth

Mental

Socid

Movement

·Mobility(dailymovement)

·Exercise

·Sleep

Stateofbeing

·Mindsets/beliefs

·Economicsecurity

·Bodycomposition

·Physicalsecurity

Exposure

·Nature

·Materials

·Atmosphere

·Stress

·Sensory

Dailyliving

·Productiveactivity

·Socialinteraction

Contentconsumption

Hygiene

Heathcare

·Vaccination

·Adherence

·Detection/diagnosis

·Clinicalintevention

Note:Driversofhealtharecomplexandnonlinear(eg,J-curves,U-curves)andinteractwithoneanother.

'ThissgroundedintheWorldHealthOrganizationsdefinitionofhealthascompletephysical,mental,andsocialwell-being;aspiritualdimensionisaddedtoreflectexposureandmeaning.

Source:LarsHartensteinandTomLatkovic,"Thesecrettogreatheath?Escapingtheheathcarematrix"McKinseyHealthInstitute,Dec20,2022

McKinsey&Company

employers,andinvestors.Thismomentumextendsbeyondthetherapiesthemselves,

helpingtoshiftperceptionsofobesity,stimulateinnovationandinvestment,andcreate

greaterurgencytoaddressmetabolichealth.GLP-1salonewillnotdeliverametabolichealthrevolution,buttheyhavehelpedopenawindowforbroaderaction-creatinganopportunityforleaderstoadvanceprevention,improveenvironmentsandincentives,andaddressthe

widerdriversofmetabolichealth.8

Apracticalhealthylivingagendacouldstartwithasmallsetofprioritydrivers(forexample,diet,physicalactivity,andclinicalinterventionstargetingmetabolicdiseases)thatarebothhighly

influentialandactionableatthepopulationlevel.Theobjectiveistobuildacoordinatedportfoliothatmakeshealthierchoicesmoreavailable,affordable,andeasiertosustain,ratherthan

prescribeasingleintervention.

Theexecutionofahealthylivingagendareliesoncross-governmentleadership.Manyof

themostimportantdriversofhealthareshapedbyministriesandsectorsthatdonotdefinethemselvesaspartofthehealthsystem,includingeducation,transport,urbanplanning,food,technology,labor,finance,andcommunitydevelopment.Atop-of-governmentperspectiveisthereforeessential:Leadersbenefitfromidentifyingwheretheburdenisgreatest,whichriskfactorsaremostaddressable,whichdriverscanbeshifted,andwhichaccountabilitiescanbecreatedtodeliverresults.

8Catalysingcross-sectorleadershipformetabolichealth,WorldEconomicForum,January2026.

Thefutureofhealthyliving:A$16.4trillionopportunity

Chapter2

Sizingcountry-specificriskfactorsshowswheretofocusforthe

greatesthealthandeconomicvalue

Governmentsthatdecidetomakehealthylivingapriorityfacethestrategicchallengeofwheretofocustheirefforts.Becausenohealthylivingagendacanaddresseverydriverofhealthatonce,apracticalapproachistoprioritize.

Theanswerdiffersbycountryandgeography.Themodifiableriskfactorsfuelingpoorhealtharenotevenlydistributedacrosspopulations,noristhehealthoreconomicvalueassociatedwithaddressingthem.Tohelpbuildapotentialknowledgebaseonwhereattentioncouldbeprioritized,MHIquantifiesthepotential.

Theanalysistakesaforward-lookingviewbysizingthevalueatstakein2050throughtwo

lenses:healthimpact,measuredthroughyearsoflifelostandyearsoflifeindisability(DALYs)

avertedbyeliminatingmodifiableriskfactors,9andeconomicimpact,measuredthroughGDP

uplift.Theseriskfactorscontributetoprematuremortalityandyearslivedinpoorhealth,directlyaffectinghowmuchtimeindividualscanspendparticipatingintheeconomy.ThepotentialGDPupliftprovidesgovernmentswithabasisforprioritizingareaswherepublicpolicy,regulation,

infrastructure,servicedelivery,andpartnershipcanpropelbothhealthoutcomesandeconomicbenefit(seesidebar"Methodologicalnote").

Thenumbersaresubstantialacrossfourbroadscenariosofeliminatingmodifiableriskfactors(Exhibit2).Globally,thepotentialeconomicimpactofinvestinginhealthylivingandeliminatingallmodifiableriskfactors(ScenarioA)couldreach$16.4trillionin2050,nearly9percentoftotalGDP.10Thetotalhealthburdenavertedreaches1.5billionDALYs,equivalenttoapproximately

47percentofglobaldiseaseburdenin2050.

9Anattribute,behavior,exposure,orotherfactorthatiscausallyassociatedwiththeprobabilityofadiseaseorinjuryandis

amendabletomodificationthroughbehavior,clinicalcare,orpolicy.Thehealthimpactoffactorssuchashighbodymassindex

(BMI)orhighsystolicbloodpressureondiseaseburdencanbequantifiedasDALYsattributabletotheseriskfactors.The

IHMEGlobalBurdenofDisease2021frameworkattributesanestimated47percentofalldiseaseburdento20riskfactors,

includingdietaryrisks,lowphysicalactivity,tobacco,airpollution,highBMl,highsystolicbloodpressure,andothers.When

appliedtotheprojected2026diseaseburden,theseriskfactorscontribute1.2billionDALYstotheglobaldiseaseburden.

10Thisisnearlythreetimesthepotentialeconomicimpactof$6trillionfromeliminatingallmodifiableriskfactorsin2026.

Sidebar

Methodologicalnote

Thisanalysisseekstomodelthe

potentialofhealthyliving-thriving

ingoodhealthtodaywhilelivingina

waythatalsomaximizesyearsingreat

healthstilltocome.Itsimpactcanbe

estimatedbymodelingaworldwithout

exposuretomodifiableenvironmental,

behavioral,andmetabolicriskfactors,

leveragingtheInstituteforHealth

MetricsandEvaluation'sGlobalBurden

ofDiseasestudy.Thisanalysisprovidesacomplementaryperspectivetoouranalysis

inTheHealthofNations.Whereasthat

workestimatedtheburdenreduction

achievablethroughspecificinterventionssupportedbyclinicalevidence,this

analysisestimatesthetheoreticalpotentialassociatedwitheliminatingrisk-factor-

attributableburden,withoutspecifying

theinterventionsrequiredtoachieveit.

Assuch,theestimatedimpactshouldbeinterpretedasanupper-boundpotential:Itassumesfulleliminationoftheriskfactors.

Whileachievingthispotentialmay

requireinterventionsbeyondthosefor

whichclinicalevidenceexiststoday,the

underlyingshiftsneededforhealthylivingareplausible.Forexample,itisconceivablethateveryoneeatshealthily,sowemodelpotentialthroughthefullelimination

ofdietaryrisk,whileHealthofNations

focusesontheimpactofexisting,clinicallyevidencedinterventionssuchasnutritionprogramsandGLP-1s.

Exhibit2

Fulleliminationofmodifiableriskfactorscouldavert47percentoftheglobaldiseaseburden,translatingintoanearly9percentannualGDPupliftin2050.

Healthandeconomicimpactin2050¹

ScenarioAAllrisks

eliminated

ScenarioB

Behavioralriskseliminated

ScenarioC

Metabolicriskseliminated³

ScenarioD

Environmentalriskseliminated

Note:ScenarioAeliminateseverymodifiablerisksimultaneousl;scenariosBthroughDeacheliminateasingleriskgroup.Scenariosarenotaditie.Eachpanelusesanindependentscale.

Counterfactualscenariomodeledacrossllisks(scenarioA)orperriskcategory(scenariosBthroughD),assuming100%ofrisk-attibutableburdenaverted.Economicimpactisestimatedbytranslatingaverteddeathsanddisabiltyintoaditionleffectiveworkforceparticpationandproductivity,adjustedforlaborforceparticipationandemployment,andvaluedusingGDPperemployedworker.

2Disability-adjustedlifeyears;oneDALYequalsoneyearofhealthyifelosttoilness,disability,orprematuredeath.

Source:GiobalBurdenofDiseaseDatabase,InstituteforHealthMeticsandEvaluation(IHME),2021,extendedto2050wia1HMEdiseaseburdenforecasts

ScenarioCwasalsomodeledinapreviouspublicationfromtheMcKinseyHeathInstituteusingthesamemethodology.Formore,seeAnasEITurabi,DrewUngerman,HemantAhlawat,andLarsHartenstein,Thepathtowardametabolichealthrevolution,"McKinseyHealthínstitute,May20,2025.Sincethatpublication,twoinputshavebeenupdated:DALYsavertedarenowestimatedfor2050(previously2022,andthe2050economicimpactnowalsoincludes caregiverproductivity.

McKinsey&Company

Thefutureofhealthyliving:A$16.4trillionopportunity

7

Thefutureofhealthyliving:A$16.4trillionopportunity

Theopportunityvariesbycountry;eachdiffersinwhatshareofthediseaseburdenismodifiable,shapedbydemographics,dominantriskfactors,andpastprogressinreducingriskstohuman

health.Countriesalsodifferinhowhealthgainstranslateintoeconomicvalue(Exhibit3).Afewexamplecountryprofilescanhelpillustratethispoint:

InSaudiArabia,thepotentialimpactonthecountry'shealthburdenisamongthehighestofthesamplecountriesanalyzed,with50percentoftheoveralldiseaseburdendrivenbymodifiableriskfactors.RelatedtrendsinSaudiArabiaincluderisingprevalenceofobesity,withhighbody

Exhibit3

Thehealthandeconomicimpactofeliminatingmodifiableriskvariesbycountry.

ImpactofscenarioAin2050,'bycountry

Country

SouthAfrica

China

SaudiArabia

UAEIndiaQatar

US

Mexico

NigeriaGermanyItaly

Canada

Denmark

Brazil

UK

Netherlands

Sweden

France

Singapore

Japan

Australia

Healthimpact

DALYs²averted,%oftotaldiseaseburden

53

50

49

45

42

39

38

38

36

35

35

NumberofDALYs²averted,millions

15

248

10

274

62

23

55

13

8

6

34

8

13

Economicimpact

GDPuplift,%

changeinGDPGDPuplift,$billion

+9661

+863,651

+106195

+8293

+981,321+1C145

+1084,790+100236

+8.677

+70369

+50116

+6.9246

+6441

263

+60286

+5680

+6153

+56209

+5439

+5.8253

+57170

ScenarioAeliminatesallmoifiableisks.Countriessortedbyhealthimpactshare,descending.Economicimpactisestimatedbytranslatingaverteddeathsanddisabilityintoadditionleffectiveworkforceparicipationandproductivityadjustedforlaborforceparticipationandemployment,andvaluedusingGDPper

employedworker.

²Dsability-adjustedlifeyears;oneDALYequalsoneyearofhealthylifelosttoillness,disability,orprematuredeath.

Source:GlobalBurdenofDiseaseDatabaseInstiufeforHealthMetricsandEvaluation(HME),2021,extendedto2050viIHMEdiseaseburdenforecasts

McKinsey&Company

massindex(BMI)becomingthenumberoneriskfactorformalesandfemalesin2021,andbehavioralriskfactorssuchasdietaryriskandtobaccoplayingarole.1

InIndia,themodifiableshareofdiseaseburdenis49percent-thefourthhighestamong

countriesanalyzed-translatingtoapotential9.8percentinGDPuplift.Thepreventable

burdeninIndiareflectsamixofpressuresonalarge,relativelyyoungpopulation.Forinstance,particulatematterairpollutioncontributesmoreDALYsinIndiathaninanyothercountry,

childhoodundernutritionhasimprovedbutremainswidespread,andobesityisincreasing.2

IntheUnitedStates,theshareofdiseaseburdenattributabletomodifiableriskfactorsislower(45percent),butstilloneofthehighestamonghigh-incomecountriesanalyzed.LeadingriskfactorsincludehighBMI,highfastingplasmaglucose,andtobaccoanddruguse.3

InItalyandGermany,40and42percentofthediseaseburdenismodifiable,respectively-a

roughly5percentrelativedifference.However,theestimatedGDPupliftdiffersmore

substantially,at5percentofGDPinItalyversus7percentinGermany,aroughly40percent

relativedifference.Italyalsoranksamongthelowestofhigh-incomecountriesanalyzedintermsofGDPupliftasapercentofGDP.Thisdemonstrateshowhealthgainstranslateintoeconomicuplift.Amongothervariables,Italyhasoneoftheworld'soldestpopulations,14meaningmore

oftheburdenfallsonolderagegroups,wherehealthgainsmaytranslatelessdirectlyintoimmediateworkforceproductivity.

Similarly,inJapan,anolderpopulationandlong-runhistoricalprogressonsmokingandbloodpressuremaybeproducingasmallermodifiableshare(35percent)thanothersamplecountries.However,opportunityremainsmeaningful,particularlyashighfastingplasmaglucosebecomestheleadingriskfactoralongsideincreasingdiabetesrates.15

Whatarepracticalwaystoprioritizewhichriskfactorstoaddress?Onewayistodefinethematicprioritiestokick-startahealthylivingagendaandgroupriskfactorsinto“packages”accordingly(Exhibit4).Forexample,governmentstakeholderscouldfocusondeliveringmetabolichealth

forall,orseeitasa"metabolichealthrevolution,"anapproachthatiscompellingincountries

withelevateddiseaseburden.Itwouldmeantargetingmetabolichealthriskfactors,including

highBMlandhighsystolicbloodpressure,aswellaskeybehaviorssuchasdietaryriskandlowphysicalactivity.AbuDhabiisonecaseinpoint(seesidebar"AbuDhabi'sHealthyLivingagenda:Across-governmentmodelexample")wherethispackageisalsobyfarthelargestpotential

valueatstake.Anotherstartingpointcouldbetofocusonwomen'shealthbyaddressingrisk

factorswheretheattributableburdenfallsdisproportionatelyonwomen,fromlowbonemineraldensitytointimate-partnerviolence.

InSaudiArabia,theagestandardizedDALYrateinthosewithhighBMImorethandoubledbetween1990and2021,

andprevalenceofmaletobaccousereachedgreaterthan26percentin2022,accordingtodatafromtheWorldHealth

Organization;AmalZaidan,"ThreedecadesoftrendsinriskfactorsattributedtodiseaseburdeninSaudiArabia:FindingsfromtheGlobalBurdenofDiseaseStudy2021,"Healthcare(Basel),July2025,Volume13,Number14.

2NehaJain,SrinivasGoli,andArjunJana."Populationagestructuraltransition,demographicdividendandeconomicgrowthinIndia,"HumanitiesandSocialSciencesCommunications,June2025,Volume12;"Temporaltrendsofparticulatematter

pollutionanditshealthburden,1990-2021,withprojectionsto2036:Asystematicanalysisfortheglobalburdenofdiseasestudy2021,"FrontiersinPublicHealth,April2025,Volume13;JithinSamVargheseetal.,"Changesinchildundernutrition

andoverweightinIndiafrom

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