2-Nitropropane-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE2-NitropropaneCat.No.:HY-W020029CASNo.:79-46-9分⼦式:C₃H₇NO₂分⼦量:89.09储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性2-Nitropropane⼀种可作为⼯业溶剂和化学中间体的DNA损伤诱导剂，具备⼝服活性。2-Nitropropane可在⼤⿏⾻髓细胞中诱导氧化性DNA损伤，可诱发肝癌的⼤⿏致癌物。2-Nitropropane可⽤于肝细胞癌等癌症的相关研究[1][2][3]。体外研究2-nitropropane(0.1-1mM;20h)inducesmarkedunscheduledDNAsynthesisinmaleWistarrathepatocytesat0.1mM,withminimalresponsesinmaleBALB/cmousehepatocytes(requiring1mMforequivalenteffect)andhumanhepatocytesatbothconcentrations[3].2-nitropropane(0.25-6.25mM;4h)producesanelectrochemicallyactivemodifieddeoxynucleosideinmaleWistarrathepatocytes(mostabundant)andmaleBALB/cmousehepatocytes(lessabundant)butnotinhumanhepatocytes,withoutincreasing8-oxo-7,8-dihydrodeoxyguanosinelevels[3].体内研究2-Nitropropane(100mg/kg;i.p.;singledose)inflictsDNAdamageinratbonemarrowcells,asindicatedbyincreasedcomettaillength(9.61±1.56μm)and8-oxodGlevels(5.14±2.42per105dG)24hoursafteradministration[1].2-Nitropropane(1mmol/kg;gavage;threetimesperweek;16weeks)inducesa100%incidenceofhepatocarcinomas(with4benignand22malignantlivertumors)inthe22effectivemaleSprague-Dawleyrats[2].AnimalModel:Wistarrats(male,6weeksold,200-220gbodyweight)[1]Dosage:100mg/kgAdministration:i.p.;singledose1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEResult:Measuredaveragecomettaillengthinbonemarrowcellsas9.61μm;detected8-oxodGlevelsinDNAas5.14per10⁵dG;observedaclosecorrelationbetweencomettaillengthand8-oxodGlevel.AnimalModel:Sprague-DawleyRats(male,150-160g)[2]Dosage:1mmol/kgAdministration:i.g.;threetimesperweek;16weeksResult:Observedbenignlivertumorsandmalignantlivertumors;Detectedlungmetastases;RecordedsignificantlylowerbodyweightsthroughoutthestudycomparedtoothergroupsREFERENCES[1].DengXS,etal.2-Nitropropane-inducedDNAdamageinratbonemarrow.MutatRes.1997;391(3):165-169.[2].FialaES,etal.Assayof1-nitropropane,2-nitropropane,1-azoxypropaneand2-azoxypropaneforcarcinogenicitybygavageinSprague-Dawleyrats.Carcinogenesis.1987;8(12):1947-1949.[3].DaviesJE,etal.DNAmodificationandrepairby2-nitropropaneisextensiveinhepatocytesofratscomparedtothoseofhumansandmice.MutatRes.1993Jun;287(2):157-64.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.