6R-7R-Epoxy-1-oleanen-3-ol-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemE(6R,7R)-Epoxy-1-oleanen-3-olCat.No.:HY-N17395CASNo.:1609645-89-7分子式:C₃₀H₄₈O₂分子量:440.7作用靶点:TNFReceptor;InterleukinRelated作用通路:Apoptosis;Immunology/Inflammation储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性(6R,7R)-Epoxy-1-oleanen-3-ol是一种三萜类化合物，存在于Boswelliaovalifoliolata中的，具有抗炎活性。(6R,7R)-Epoxy-1-oleanen-3-ol可抑制LPS(HY-D1056)激活的小鼠中性粒细胞中TNF-α、IL-6、IL-8及NO的生成。(6R,7R)-Epoxy-1-oleanen-3-ol可用于炎症性疾病的相关研究[1]。IC50&TargetIL-6IL-8体外研究(6R,7R)-Epoxy-1-oleanen-3-ol(compound2)(1μM;3h)significantlyinhibitsintracellularTNF-αexpressionby55.01%inLPS-activatedmurineneutrophils[1].(6R,7R)-Epoxy-1-oleanen-3-ol(1μM)significantlyreducesintracellularIL-6andIL-8levelsinLPS-activatedmurineneutrophils[1].(6R,7R)-Epoxy-1-oleanen-3-ol(1μM;4-5h)significantlyinhibitsextracellularNOproductioninLPS-activatedmurineneutrophils[1].(6R,7R)-Epoxy-1-oleanen-3-ol(1-100μM)showsnocytotoxicityinTHP1,COLO-205,orA549cellsat1μMor10μMbutinhibitsgrowthby77%(THP1)and81%(A549)at100μM[1].ELISAAssay[1]CellLine:murineneutrophilsConcentration:1μMIncubationTime:4-5hResult:SignificantlyinhibitedextracellularNOproductioninmurineneutrophils.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEReducedNOlevelsfrom237.74to139.66μmol/mL.REFERENCES[1].RenuChib,etal.Anti-inflammatoryterpenoidsfromBoswelliaovalifoliolata.RSCAdv.,2014,4,8632.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5895