8-Demethyleucalyptin-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE8-DemethyleucalyptinCat.No.:HY-N16702CASNo.:5689-38-3分⼦式:C₁₈H₁₆O₅分⼦量:312.32作⽤靶点:DrugDerivative作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性8-Demethyleucalyptin⼀种天然的酮。体外研究8-Demethyleucalyptin(CompoundC2)exhibitsbacteriostaticactivityagainstMSSAATCC25923andMRSAATCC33591withMICof31.25μg/mLand62.5μg/mL[1].8-Demethyleucalyptin(15.625-31.25μg/mL;48h)inhibitsbiofilmformationofMRSAandMSSAwithinhibitionrateof31.6%and37.1%[1].8-Demethyleucalyptin(15.625-31.25μg/mL;48h)weaklyinhibitsstaphyloxanthinbiosynthesisofMRSAandMSSAwithinhibitionrateof14.2%and22.2%andreducesacidtolerance[1].8-Demethyleucalyptin(31.25-62.5μg/mL;18h)disruptscellmembraneandwallintegrityinMSSAandMRSA[1].8-Demethyleucalyptin(48-72h)inhibitsHCT116andMRC-5cellsviability(IC50=6.4and7.0μMandIC50>100μMforJurkatcells)[2].REFERENCES[1].ShehabeldineAM,etal.Callistemoncitrinusbioactivemetabolitesasnewinhibitorsofmethicillin-resistantStaphylococcusaureusbiofilmformation.JEthnopharmacol.2020;254:112669.[2].AsakawaR,etal.Synthesisandcytotoxicactivitiesof8-and6-demethyleucalyptins.BiosciBiotechnolBiochem.2022;86(9):1200-1206.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: