18-0-18-1-PS-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE18:0,18:1PSCat.No.:HY-148978ACASNo.:124262-93-7分⼦式:C₄₂H₈₀NO₁₀P分⼦量:790.06作⽤靶点:Liposome;EndogenousMetabolite作⽤通路:MetabolicEnzyme/Protease储存⽅式:-20°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)BIOLOGICALACTIVITY⽣物活性18:0,18:1PS细胞、外泌体及HIV颗粒中优势的磷脂酰丝氨酸亚型，在⼤脑中含量丰富，对维持膜结构、脂筏组织及细胞内转运⾄关重。18:0,18:1PS以胆醇依赖的⽅式与超长链鞘脂相互作⽤介导膜⼩叶间偶联，并能诱导糖磷脂酰肌醇锚定蛋⽩的聚集。此外，18:0,18:1PS与胆醇结合形成的簇不仅有助于胆醇在双层膜中的正确分布，还能有效保护胆醇免受氧化损伤[1][2]。体外研究18:0,18:1PSisthedominantphosphatidylserinesubtypeincells,exosomesandHIVparticles[1]:(1)PS18:0,18:1accountsforapproximately22-60%oftotalPSinvariouscelllinesincludingPC-3,HEp-2,PSA3CHO,HeLa,MT4,A549andmousefibroblastcelllines.(2)PS18:0,18:1accountsforapproximately40%oftotalPSspeciesinexosomesderivedfromPC-3cells,andtheoreticallycoversabout80%oftheinnerleafletareaoverlappedbyverylong-chainsphingolipidsontheouterleaflet[1].(3)PS18:0,18:1theoreticallycoversabout60%oftheinnerleafletareaoverlappedbyverylong-chainsphingolipidsontheouterleafletofHIV-1particles.Thecross-intercalationbetweenPS18:0,18:1andSMd18:1/24:0isstrongerthanthatbetweenPS16:0/18:1(HY-146885),anditistheonlytestedPSspecieswhosecross-intercalationwithSMd18:1/24:0isenhancedinthepresenceofcholesterol[1].PS18:0,18:1canco-drivephaseseparationwithcholesterolinGUVs,andmoreeffectivelyprotectcholesterolfromtheactionofcholesteroloxidasecomparedwithPS16:0/18:1,PS18:1/18:1andPS16:0/18:2[1].PS18:0,18:1promotestheclusteringofendogenousGPI-APsonthesurfaceofPSA3CHOcells,withanefficacycomparabletothatofPS18:0/18:0andmorepotentthanthatofPS18:1/18:1orPS12:0/12:0[1].1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE体内研究18:0,18:1PSishighlyenrichedinratbrainphosphatidylserinerelativetoheart,kidney,andliver,comprising26%oftotalbrainphosphatidylserine[2].REFERENCES[1].SkotlandT,etal.TheroleofPS18:0/18:1inmembranefunction.NatCommun.2019;10(1):2752.Published2019Jun21.[2].ChoiJ,etal.Comprehensiveanalysisofphospholipidsinthebrain,heart,kidney,andliver:brainphospholipidsareleastenrichedwithpolyunsaturatedfattyacids.MolCellBiochem.2018;442(1-2):187-201.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forr