病理学--绪论.ppt

1、Pathology （第六版教材-第四版课件） Lijiang Liu （刘丽江）,刘丽江 （1955-） 医学学士 病理学与病理生理学教研室 主任 教授 硕士生导师 1982年毕业于武汉医师进修学院 享受国务院和武汉市政府专项津贴 市管优秀专家,现任：中国病理学工作者委员会 副主任委员 中国抗癌协会肿瘤转移专业委员会 常委 中国抗癌协会湖北分会肿瘤病理委员会 常委 中华医学会湖北省病理学会 常委 中华医学会武汉病理学会 副主任委员,department of pathology,主要研究方向： 胃癌淋巴结转移 结直肠癌与乳癌的转移 病理学教学及教学评价研究,主要研究成果： 获武汉市科技进步二

2、、三等奖 4 项 正式发表论文 52 篇,department of pathology,department of pathology,办公室：J12-C202 电话：027-51259966汉口校区） E-mail：,department of pathology,Introduction to pathology,department of pathology,disease? disease can be define as any condition that the presence of an abnormality of

3、the body cause a loss of normal health,Pathology? is the scientific study of disease,the metabolism the functional the morphological,changes,occur during the course of the disease,department of pathology,general pathology (15 chapter) the mechanisms and characteristics of the principal types of dise

4、ase process systemic pathology (616 chapter) the descriptions of specific disease as they affect individual organs or systems,department of pathology,Pathology include: Pathoanatomy: anatomical method disease Pathophysiology: physiological method disease,In china:,department of pathology,Pathology i

5、nclude:,Histopathology Haematology Chemical pathology Microbiology Immunopathology,In west:,department of pathology,Pathology include:,Histopathology Haematology Chemical pathology Microbiology Immunopathology,In west:,department of pathology,Histopathology the study of histological abnormalities of

6、 disease cells and tissues,department of pathology,Pathology include:,Histopathology Haematology Chemical pathology Microbiology Immunopathology,In west:,department of pathology,Haematology the study of primary or secondary disease of the blood,department of pathology,Pathology include:,Histopatholo

7、gy Haematology Chemical pathology Microbiology Immunopathology,In west:,department of pathology,Chemical pathology the study of biochemical abnormalities associated with disease,department of pathology,Pathology include:,Histopathology Haematology Chemical pathology Microbiology Immunopathology,In w

8、est:,department of pathology,Microbiology the study of infectious disease and organism that cause them,department of pathology,Pathology include:,Histopathology Haematology Chemical pathology Microbiology Immunopathology,In west:,department of pathology,immunopathology the study of disease through a

9、nalysis of immune function,department of pathology,total of to say, Pathology: clinical pathology - diagnosis of disease experimental pathology - animal models molecular pathology - gene and gene product,department of pathology,department of pathology,total of to say, Pathology: clinical pathology (

10、human pathology) (surgical pathology),clinical pathology,department of pathology,Clinical pathology,department of pathology,The animal experiments,department of pathology,molecular pathology,department of pathology,gene and gene product,Molecular pathology,department of pathology,Molecular pathology

11、,department of pathology,methods of pathology: 1. gross pathology 2. light microscopy 3. histochemistry 4. immunohistochemistry and immunofluorescence 5. electron microscopy 6. cell cultures 7. molecular pathology,department of pathology,methods of pathology: 1. gross pathology 2. light microscopy 3

12、. histochemistry 4. immunohistochemistry and immunofluorescence 5. electron microscopy 6. cell cultures 7. molecular pathology,department of pathology,especially in the autopsy : with unaided eye an important investigative method Now: It is obvious to reduce,department of pathology,Autopsy diagram,a

13、utopsy,department of pathology,autopsy,department of pathology,autopsy,department of pathology,男，59 岁。 晨6时发现死在值班室内。,autopsy,department of pathology,autopsy,department of pathology,Autopsies: determining the cause of death audit of clinical diagnosis education research into the causes and mechanism o

14、f disease gathering accurate statistics about disease incidence,methods of pathology: 1. gross pathology 2. light microscopy 3. histochemistry 4. immunohistochemistry and immunofluorescence 5. electron microscopy 6. cell cultures 7. molecular pathology,department of pathology,especially in the biops

15、y an important method of clinical diagnosis,eye + light microscopy (HE stain),department of pathology,biopsy,department of pathology,biopsy,department of pathology,biopsy,department of pathology,methods of pathology: 1. gross pathology 2. light microscopy 3. histochemistry 4. immunohistochemistry an

16、d immunofluorescence 5. electron microscopy 6. cell cultures 7. molecular pathology,department of pathology,histochemistry,department of pathology,methods of pathology: 1. gross pathology 2. light microscopy 3. histochemistry 4. immunohistochemistry and immunofluorescence 5. electron microscopy 6. c

17、ell cultures 7. molecular pathology,department of pathology,immuohistochemistry and immunofluorescence employ antibody to visualise substances in tissue sections or cell preparations antibody linked chemically to enzymes or fluorescent colour reaction,department of pathology,immunohistochemistry sta

18、in,department of pathology,methods of pathology: 1. gross pathology 2. light microscopy 3. histochemistry 4. immunohistochemistry and immunofluorescence 5. electron microscopy 6. cell cultures 7. molecular pathology,department of pathology,department of pathology,methods of pathology: 1. gross patho

19、logy 2. light microscopy 3. histochemistry 4. immunohistochemistry and immunofluorescence 5. electron microscopy 6. cell cultures 7. molecular pathology,department of pathology,cell cultures,department of pathology,methods of pathology: 1. gross pathology 2. light microscopy 3. histochemistry 4. imm

20、unohistochemistry and immunofluorescence 5. electron microscopy 6. cell cultures 7. molecular pathology,department of pathology,in situ hybridisation in situ polymerase chain reaction to render the presence of specific genes or their mRNA visible in tissue section or cell preparations in situ hybrid

21、isation minute quantities of nucleic acids in situ PCR,molecular pathology,department of pathology,new technique : flow cytometry image analysis laser microdissection tissue microarrage,department of pathology,flow cytometry,department of pathology,image analysis,department of pathology,laser microd

22、issection,department of pathology,tissue microarrage technology,department of pathology,Pathology development history,Gross section,microscopy,immunohistochemistry,Anatomy pathology,History pathology,Cellular pathology,Molecular pathology,DNA , RNA and Protein analysis,molecular pathology,department of pathology,department of pathology,department of pathology,teaching arrangement total: 112 (learn the hours) theories lesson: 60 experiment lesson: 36 restrict elective lesson: 16,department of patholo