复旦生物无机化学b.ppt

1、Chapter 2 Bioinorganic Chemistry of Alkali and Alkaline Earth Metals,2.1 Distribution and Biological Roles 2.2 Trans-membrane Ion Transport Passive and Active Transport（被动和主动运送） Ionophore and Ionic Channel（离子载体和离子通道） 2.3 Active Transport: Na+-K+-ATPase 2.4 Calcium as a Secondary Messanger,Biological

2、 Roles of Alkali and Alkaline Earth Metals,Na, K: electric carrier; activator for Na- K-ATPase; osmotic balance Mg: activator for Na-K-ATPase; kinase; structure role; hydrolase; isomerase Ca: structure role; trigger for muscle contraction; component fo bones and shells; messenger for hormonal action

3、,Distribution of Intracellular and Extracellular Ions in and out of a Typical Mammalian Cell,Ion Mn+in(mM) Mn+out(mM) Na+ 10 145 K+ 140 5 Mg2+ 30 1 Ca2+ 1 4 H+ 510-4 5 10-4 Cl- 4 110,Ionophores,Marcoterolides 大四内酯 Desipeptides 缩肽类 Cyclic Peptides 环肽 Nigericins 尼日尼亚菌 Ion Channels Nystatin 制霉菌素 Amphot

4、ericin 两性霉素 Gramicidin 短杆菌素,Ion Transport across Membrane跨膜的离子运送,Passive Transport 沿着离子的化学势方向进行，即离子顺其浓度梯度从较浓一侧运送到较稀一侧。被动运送又分为简单扩散和促进运送。促进运送需要离子载体和离子通道。 Active Transport 离子逆浓度梯度和点化学梯度通过生物膜的运送。主动运送通常许消耗能量。执行主动运送的机制常被称为离子泵 例：Na+-K+-ATPase,Na+-K+-ATPase Two subunits Mr 250000-500000 Mg 2+ necessary Na+/

5、K+: 10:1-5:1 K+: NH4+, Ti+ Mg2+: Mn2+, Co2+,Bioinorganic Chemistry of Calcium,Role in Muscle Contraction Effects on Enzymes Enzyme Stabilization Blood Clotting Calcium-Membrane Interactions Never Impulse Transmission Effects on Membrane Structure and Action Potential Release of Neurotransmitters and Hormones Hormones, Cyclic