银屑病免疫治疗.ppt

1、in Psoriasis,Immunopathogenesis,Biologic Therapeutics, (2) cyclosporine and tacrolimus are effective; (3) flare of symptoms during perturbation of the immune system or interferon treatment; (4) new lesions are induced by injection of IFN into nonlesional skin of the patient.,Subsequent studies demon

2、strated the predominance of activated Tc1 in the epidermis, activated TH1 in the dermis, the presence of mature LCs, and the expression of CD31, CD34 and PNAd on endothelial cells, in the psoriatic lesions.,From J G Krueger, 2002,Most direct evidence was the results of DAB389 IL-2(a fusion protein c

3、omposed of human IL-2 sequence and a fragment of diphtheria toxin) on the treatment of psoriasis.,New biologic therapeutics for psoriasis,Abs(chimeric, humanized, human sequence) fusion proteins recombinant cytokines,Designed to target specific immune-activation steps with least global immune suppre

4、ssion, blocking the cell surface molecules and the cytokines participating in the inflammatory process.,From J G Krueger, 2002,Targeting primary stimulation Targeting costimulation Targeting T cell proliferative signals Immune deviation Blockade of effector cytokines,Strategies for Immunobiologic Th

5、erapy of Psoriasis,Therapeutic Agents Targeting Primary Stimulation,Therapeutic Agents Targeting Costimulation,Therapeutic Agents Targeting T cell Proliferative Signals,Therapeutic Agents Blocking Effector Cytokines,Before Treatment,After Treatment,Publications About 600 papers published in journals, such as : J Immunol J Invest Dermatol Archiv Dermatol Br J Dermatol Acta Derm Venereol Dermatol Surg J Am Acad Dermatol J Cutaneous Pathol J Appl Cosmetol Clin Exp Dermatol Connect Tissue Res Int J Dermatol Transplantation Dis Markers J Dermatol Int Arch Alle Appl Immunol Tissue Antige