微混合器研究进展_第1页
微混合器研究进展_第2页
微混合器研究进展_第3页
微混合器研究进展_第4页
微混合器研究进展_第5页
已阅读5页,还剩24页未读 继续免费阅读

下载本文档

版权说明:本文档由用户提供并上传,收益归属内容提供方,若内容存在侵权,请进行举报或认领

文档简介

1、.,微混合器研究进展,Seminar ,学生: 赵玉潮 导师: 袁 权 院 士 陈光文 研究员,微化工技术组 2006/5,.,主要内容,材质与加工方法 流动特性分析 微混合器分类 混合效果评价方法,.,(一)材质与加工方法,不锈钢 铝片 硅 石英和玻璃 硬质高分子聚合物 弹性聚合物 光敏聚合物,机械微加工 湿法刻蚀 干法刻蚀 高分辨刻蚀(LIGA) 注塑 原位聚合 热压 气相沉积 软刻蚀,.,(二)微混合器内流体流动特点,.,微尺度下混合原则,.,(三)微混合器分类,.,从动式微混合器的特点,优点 结构简单 操作稳定 容易集成 成本较低 易自动化,缺点 混合时间长 混合效果差,.,平行迭片,

2、从动式,.,平行迭片,从动式,.,平行迭片,从动式,.,平行迭片,IMM公司的Ehrfeld小组设计了一种交趾式微混和器,从动式,.,串联迭片,从动式,.,串联迭片,从动式,通过优化微通道结构,使流体层层叠加,He等设计了一种小体积、小流速的微混合器,.,注射式微混合器,从动式,.,混沌对流,从动式,中等雷诺数区域(10Re100):,.,混沌对流,从动式,.,混沌对流,从动式,.,混沌对流,从动式,.,主动式微混合器的特点,优点 混合时间短 混合距离短 可选择性大 适于极低Re数,缺点 不易集成 成本较高 制作困难 材质要求高,.,脉冲扰动,主动式,压力扰动,速度脉冲侧线进料,微搅拌(外加电

3、磁场),.,电场扰动,主动式,Moctar等把电极置于微通道内,改变电极两端电压和频率,使两种不同性质的流体按不同轨迹运动,在微通道内产生混沌对流,结果发现在Re=0.02时就能达到较好混合效果,.,其它能量形式,磁动力:在外加磁场作用下,电极上产生直流电,使电解质溶液中带电粒子受到罗仑兹力,并带动流体翻转、折叠,增加接触面积; 超声波:用声波来搅拌微混合器内的流体; 电动力:通过外加电流,改变电渗流速度大小和方向,产生混沌对流,达到强化混合过程的目的; 热扰动:改变扩散系数D,如利用热泡产生流体扰动,以强化混合过程,主动式,.,(四)混合效果评价,.,混合效果评价可视化方法,标记物技术,共聚

4、焦检测技术,微粒成像技术(实验),微粒成像技术(模拟),.,混合效果评价竞争反应法,传统工程学派方法:,.,参考文献,1 微流控分析芯片的制作及应用,方肇伦主编,2005; 2 M. Kakuta, F. G. Bessoth and A. Manz, Microfabricated devices for fluid mixing and their application for chemical synthesis, Chem. Rec. 1 (2001), 395-405. 3 J.M. Ottino, W.E. Ranz, C.W. Macosko, Chem. Eng. Sci.,

5、 1979, 34: 877-890. 4 A . E. Kamholz and P. Yager, Molecular diffusive scaling laws in pressure-driven microfluidic channels: deviation from one-dimensional Einstein approximations, Sensor Actuators B, 82 (2002), 117121. 5 S.H. Wong, M.C.L. Ward, C.W. Wharton, Micro T-mixer as a rapid mixing micromi

6、xer, Sensors and Actuators B: Chemical 2004, 100, 365-385. 6 S. H. Wong,M.C.L. Ward ,C. W. Wharton,Micro T-mixer as a rapid mixing micromixer,Sensors and Actuators B 2004,100,359379. 7 M. Koch, H. Witt, A. G. R. Evans and A. Brunnschweiler, Improved characterization technique for micromixer, J. Micr

7、omech. Microeng. 9 (1999), 156-158. 8 J. B. Knight, A. Vishwanath, J. P. Brody and R. H. Austin, Hydrodynamic focusing on a silicon chip: mixing nanoliters in microseconds, Phys. Rev. Lett. 80 (1998), 38633866. 9 N.T. Nguyen, X.Y. Huang, Mixing in microchannels based on hydrodynamic focusing and tim

8、e-interleaved segmentation: modelling and experiment, Lab Chip, 2005, 5, 13201326. 10 B. He, B.J. Burke, X. Zhang, R. Zhang, F.E. Regnier, A picoliter-volume mixer for microfluidic analytical systems, Anal. Chem. 2001,73, 19421947. 11 W. Ehrfeld, V. Hessel, S. Kiesewalter, H. Lwe, T. Richter, J. Sch

9、iewe, Microreaction Technology: Industrial Prospects; Springer: Berlin, 2000; p14. 12 B. L. Gray et al, Novel interconnection technologies for integrated microfluidic systems, Sensors Actuators A, 77 (1999), 5765. 13 M. S. Munson and P. Yager, Simple quantitative optical method for monitoring the ex

10、tent of mixing applied to a novel microfluidic mixer, Anal. Chim. Acta, 507 (2004), 6371.,.,14 V. Mengeaud, J. Josserand and H. H. Girault, Mixing processes in a zigzag microchannel: finite element simulation and optical study, Anal. Chem. 74 (2002), 42794286. 15 N. T. Nguyen and Z. G. Wu, Micromixe

11、rs-a review, J. Micromech. Microeng. 15 (2005), 1-16. 16 C. C. Hong, J. W. Choi and C. H. Ahn, A novel in-plane microfluidic mixer with modified tesla structures, Lab on a Chip 4 (2004), 109113. 17 R. H. Liu et al, Passive mixing in a three-dimensional serpentine microchannel, J. Microelectromech. S

12、yst. 9 (2000), 190197. 18 R. A. Vijiayendran et al, Evaluation of a three-dimensional micromixer in a surface-based biosensor, Langmuir, 19 (2003), 18241828. 19 H. Chen and J. C. Meiners, Topologic mixing on a microfluidic chip, Appl. Phys. Lett. 84 (2004), 21932195. 20 S. J. Park et al, Rapid three

13、-dimensional passive rotation micromixer using the breakup process J. Micromech. Microeng. 14 (2004), 614. 21 C. P. Jen et al, Design and simulation of the micromixer with chaotic advection in twisted microchannels, Lab on a Chip, 3 (2003), 7781. 22 T. J. Johnson, D. Ross and L. E. Locascio, Rapid m

14、icrofluidic mixing, Anal. Chem. 74 (2002), 4551. 23 A. D. Stroock, S. K. W. Dertinger, A. Ajdari, I. Mezic, H. A. Stone and G. M. Whitesides, Chaotic mixer for microchannels, Science, 295 (2002), 647-651. 24 Fujii et al, A plug and play microfluidic device, Lab on a Chip, 3 (2003), 193197. 25 I. Gla

15、sgow and N. Aubry, Enhancement of microfluidic mixing using time pulsing, Lab on a Chip, 3 (2003), 114120. 26 L. H. Lu, K. S. Ryu and C. Liu, A magnetic microstirrer and array for microfluidic mixing, J. Microelectromech. Syst. 11 (2002), 462469. 27 A. O. El Moctar, N. Aubry and J. Batton, Electrohy

16、drodynamic micro-fluidic mixer, Lab on a Chip, 3 (2003), 273280.,参考文献(续),.,28 H. H. Bau, J. Zhong and M. Yi, A minute magneto hydro dynamic (MHD) mixer, Sensors Actuators B, 79 (2001), 207215. 29 J. C. Rife et al, Miniature valveless ultrasonic pumps and mixers, Sensors Actuators A 86 (2000), 135140

17、. 30 S. C. Jacobson, T. E. McKnight and J. M. Ramsey, Microfluidic devices for electrokinematically driven parallel and serial mixing, Anal. Chem. 71 (1999), 44554459. 31 H. Mao, T. Yang and P. S. Cremer, A microfluidic device with a linear temperature gradient for parallel and combinatorial measure

18、ments, J. Am. Chem. Soc. 124 (2002), 44324435. 32 J. H. Tsai and L. Lin, Active microfluidic mixer and gas bubble filter driven by thermal bubble pump, Sensors Actuators A, 9798 (2002), 665671. 33 J.R. Bourne, F. Kozicki, P. Rys, Mixing and fast chemical reactiontest reactions to determine segregati

19、on, Chem. Eng. Sci. 1981, 36, 1643. 34 A. Karoui, F. Hakenholz, N. Le Sauze, J. Costes, J. Bertrand, Determination of the mixing performance of Sulzer SMV static mixers by laser induced fluorescence, Can. J. Chem. Eng. 1998,76, 522. 35 A. D. Stroock and G. M. Whitesides, Controlling flows in microch

20、annels with patterned surface charge and topography, Acc. Chem. Res. 36 (2003), 597604. 36 R. F. Ismagilov et al, Experimental and theoretical scaling laws for transverse diffusive broadening in two-phase laminar flows in microchannels, Appl. Phys. Lett. 76 (2000), 23762378. 37 W. Ehrfeld, K. Golbig, V. Hessel, H. Loewe, T. Richter, Characterization of mixing in micromixers by a test reaction: single mixing units and mixer arrays, Ind. Eng. Chem. Res. 1999, 383, 1075. 38 M.C. Fournier, L. Falk, J. V

温馨提示

  • 1. 本站所有资源如无特殊说明,都需要本地电脑安装OFFICE2007和PDF阅读器。图纸软件为CAD,CAXA,PROE,UG,SolidWorks等.压缩文件请下载最新的WinRAR软件解压。
  • 2. 本站的文档不包含任何第三方提供的附件图纸等,如果需要附件,请联系上传者。文件的所有权益归上传用户所有。
  • 3. 本站RAR压缩包中若带图纸,网页内容里面会有图纸预览,若没有图纸预览就没有图纸。
  • 4. 未经权益所有人同意不得将文件中的内容挪作商业或盈利用途。
  • 5. 人人文库网仅提供信息存储空间,仅对用户上传内容的表现方式做保护处理,对用户上传分享的文档内容本身不做任何修改或编辑,并不能对任何下载内容负责。
  • 6. 下载文件中如有侵权或不适当内容,请与我们联系,我们立即纠正。
  • 7. 本站不保证下载资源的准确性、安全性和完整性, 同时也不承担用户因使用这些下载资源对自己和他人造成任何形式的伤害或损失。

评论

0/150

提交评论