颞叶附加癫痫【业界研究】

1、Temporal plus epilepsy ( TPE ),周健 神经外科 首都医科大学 三博脑科医院 中国. 北京 2016.5,颞叶癫痫的手术疗效,Of 168 patients included, 108 (63.7%) underwent stereoelectroencephalography, 131 (78%) had hippocampal sclerosis, 149 suffered from unilateral temporal lobe epilepsy (88.7%), one from bitemporal epilepsy (0.6%) and 18 (10.

2、7%) from temporal plus epilepsy. The probability of Engel class I outcome at 10 years of follow-up was 67.3% (95% CI: 63.471.2) for the entire cohort, 74.5% (95% CI: 70.678.4) for unilateral temporal lobe epilepsy, and 14.8% (95% CI: 5.923.7) for temporal plus epilepsy. Multivariate analyses demonst

3、rated four predictors of seizure relapse: temporal plus epilepsy (P0.001), postoperative hippocampal remnant (P = 0.001), past history of traumatic or infectious brain insult (P = 0.022), secondary generalized tonic-clonic seizures (P = 0.023).,颞叶附加癫痫的简介,The term of temporal plus (Tt) epilepsies has

4、 recently been suggested (Ryvlin and Kahane, 2005) to describe specific forms of seizures of multilobar origin which are characterized by the involvement of a complex epileptogenic network including the temporal lobe and the closed neighboured structures, such as the orbito-frontal cortex, the insul

5、a, the frontal and parietal operculum and the temporoparietooccipital junction. In a depth EEG study aiming at verifying the role of the perisylvian cortex in seizures involving the temporal lobe, Kahane et al. (2001) showed that six of the seven patients in whom seizures arose from temporal and sup

6、rasylvian opercular cortices, and in whom an adequate temporo-perisylvian resection could be achieved, were totally seizure-free after surgery.,Temporal lobe surgery alone was unsuccessful in the two temporo-insular cases of Isnard et al. (2004), since it allowed them to suppress the seizures of tem

7、poral lobe origin, but not those which arose from the insula. Moreover, anterior temporal resection did not benefit the patients with ictal temporo-parietal symptoms (reported by Aghakhani et al., 2004) Temporal lobectomy failed to control seizures in four of the six patients with posterior basal te

8、mporal ictal onset, reported by Prasad et al. (2003),癫痫外科的术前评估,Phase IHistory, Physical ,VEEG Monitoring Neuropsychology testing, Imaging ( CT,MRI, PET, SPECT, MRS, fMR) Phase IIIntracarotid Amytal Test ( WADA ),Phase IIIIntracranial Monitoring with a combination of depth, Strip, and Grid Electrodes

9、,癫痫外科的术前评估,Case discussion,Yuan M Female,26yrs R-handed,病例特点辅助检查 头皮脑电图 头颅MRI 头PET 神经心理评估颅内电极置入,病例特点,女性，26岁，右利手，病史14年 现病史： 12岁首次发作，主要表现为：GTCS，持续约1-2min缓解，此后一周内出现2次类似症状，服用丙戊酸钠后2年无发作； 目前发作类型：精神先兆（似曾相识感）言语自动自动运动（吞咽、双手摸索）GTCS，发作后不能回忆发作过程 治疗：丙戊酸钠、拉莫三嗪 个人史：母孕期正常，足月顺产，无生后缺氧窒息史；生长发育正常 家族史：否认类似家族史,Scalp EEG B

10、Ga -Yuan M,Scalp EEG SZ -Yuan M,Scalp EEG SZ continued-Yuan M,Scalp EEG SZ continued-Yuan M,Scalp EEG SZ continued-Yuan M,Scalp EEG SZ continued-Yuan M,Scalp EEG SZ continued-Yuan M,头皮脑电图,间歇期：未见典型癫痫样放电 发作期：1.临床：全身动作减少自动运动 植物神经症状复杂运动 2.EEG：发作型，弥漫性，左侧前头部,辅助检查,头皮脑电图 头颅MRI 头PET 神经心理评估,辅助检查,头皮脑电图 头颅MRI 头

11、PET 神经心理评估,左侧半球,左侧半球： A 颞中回-杏仁核（16） B 颞中回-海马头（16） C 颞中回中部-海马旁回（16） D 颞中回后部-海马后部（16） E 颞上回-第2岛长回（12） F 颞极（12） J 额中回-第2-3岛短回、第1岛长回（斜视16） L 角回-扣带回（16） M 颞中回后部颞枕交界-颞底-海马头下方（斜插16） N 额上回-扣带回-额底内侧面（斜插16） 右侧半球 B 颞中回-海马头（16）,左侧半球,左侧半球： A 颞中回-杏仁核（16） B 颞中回-海马头（16） C 颞中回中部-海马旁回（16） D 颞中回后部-海马后部（16） E 颞上回-第2岛长回（12） F 颞极（12） J 额中回-第2-3岛短回、第1岛长回（斜视16） L 角回-扣带回（16） M 颞中回后部颞枕交界-颞底-海马头下方（斜插16） N 额上回-扣带回-额底内侧面（斜插16） 右侧半球 B 颞中回-海马头（16）,SEEG SZ onset-Yuan M,临床：精神先兆（1/5）自动运动植物神经症状复杂运动（1/5）LOC EEG：