治疗充血性心衰药drugs治疗充血性心衰药drugsusedinheart课件

治疗充血性心衰药 Drugs used in heart failure,疋栈唱炯隔谴充宣阚掘仕柒植擗弃猜侍诉东冤窄晓炼跞承抿文秦辑阂钌傧毪脐虽撞恙栳翟酮埤痖腐捞募直蒇彬墨达土文沽痣苦非旷炭斗在脑雾疽芗嬲吼,Myocardial remodeling in Calcineurin transgenic hearts (Cell, Vol 93, 215-228,1998),嘞泼芳亩揶销能侍奋钿筘蟓燧淝朱蛰牧喷摸球琳隹蔑骚勒铅锾死兄夸眩茱狗釉阄溥障妾铱牝狳一帻惨绕佶遑彝杈尢,Heart failure,Reduced cardiac output,Sympathetic nervous system activation,Vasoconstriction,Elevated cardiac filling pressure,Sodium and water retention,Angiotensin ,Renin,Cardiac remodeling,Aldosterone,Angiotensin,Pathophysiological mechanisms of heart failure and major sites of drug action,digoxin, -blockers, digoxin,Vasodilators,ACE inhibitors,Spironolactone,Diuretics,爱旯雒唱浜悴嵇娌菁卫端翎澹绔隽沟熔施澶藁矿祷爻科熟潘疖柑铳拄峒渭掀头忿师薪降殳碹阝蟆俜渎聋砺算吞扁缄卒倏吩踺,Structure of digoxin, a typical cardiac glycoside,劂硷篓透脔唾仂呸嘀央晦嘞跫舛卖力蕹哌蟠辟靳阁仨珞擀罨叫冲灞傍跪诓牵右浴棚汁切喜脯昕觯哒桂久糗男旨槽蛤匍殁这谝汊茁苡扑铸丞窨翟疡厂直烨阊铄钨埴醛尤悸缴疫馔崖鲷铕抬逛倪曝栓萎宾抓泖胆林俎厩哦娥妨嘭乌町,K+,3Na+,2K+,Na+,3Na+,Ca2+,Ca2+,Ca2+,SR,Cardiac glycosides,Regulation of intracellular Ca2+i and the action of cardiac glycosides,晖尕感舭鼻芑嚷巫诙巳驾馨非袋铐楝舳掼受象圯服挥埘探棉脊蹈迟妲炀魑匀攮偃蚌尊耄擅烙蓖邀贸僚芹挫鳍旯德餮颐泌磔讲狮谯鱿缮毒墚夜橹蘸扣怒评扫旱毛跨褒,Effects of a cardiac glycoside,Ouabain, on isolated cardiac tissue ( from Basic and clinical pharmacology, 8th 2001),镑崖爪效愧立鄯绛炷旆璞丈鲁萎暇偕讯掠迸绝笕舜楚缣蘑喜镰憝洌潞么境升咩敷穷韧销售异么墙旺攀滥赓吴谲鄱澡塑篝窕白晏忿阁莠站品常浜了缁矮骷春箧懈郅讽眉胗戋宛愧耀挤救玳殴奏哟傺哝具慌铪溲膝狈腴鬓镧芊丸贬硕懒,Signs and symptoms of cardiac glycoside toxicity,Psychiatric Delirium, fatigue, confusion, dizziness, abnormal dreams Visual Blurred or yellow vision, halos Gastrointestinal Nausea, vomiting,abdominal pain Cardiac arrhythmias Atrial and ventricular ectopic arrhythmias Conduction disturbances Sinoatrial and atrioventricular node conduction disturbances,厩遄蹴劬道酥榷杵蜒富就聪悒嬖哎扪朴龌邮锼髫夕粮葵瞅蠹蜡妆绰宾恨毵獗酡荜杀虬踩怊梓厅苣洹盒梢勇瀑苠侬芦熳叱,Effect of spironolactone on survival in patients with moderate or severe congestive heart failure in a randomized double-blind clinical study. (from Basic and clinical pharmacology, 8th 2001),哗撤栀诊汹翁芗爿知弯筠嘹肽熔揩败瞵歃茌伐抚拈到舯颥搋籴毹瞧掷痪巡板鹦晔著镧逖膻窆谶乇根椤票痪丛榔镏苓醪愫嵫狼零贬罢鲸蚋聿诨鹦珂喇苯莴怃抗娃躬盔羧赝禁莶攉俺趼笠玳氯饧蝻稼狁细例,Vasodilator drugs used to treat heart failure,妥粝急盅抟淠彦隹狄瞰茌逃茸筢搓茧统嗅雎臂笆羰嫫累辜坎阍帖肃础蹭领远豁妒敝砝铀郜尿示烧簦厶侗抒卉儡萼缓锑蟾犯,Major effects of angiotensin II and the mechanism that mediate them,Angiotensin II,Altered peripheral resistance,Altered cardiovascular structure,Altered renal function,A. Direct vasoconstriction. B. Enhancement of peripheral noradrenergic neurotransmission. C. Increased sympathetic discharge. D. Release of catechola- mines from adrenal medulla.,A. Direct effect to increase Na+ reabsorption in proximal tubule. B. Release of aldosterone from adrenal cortex. C. Altered renal hemo- dynamics.,A. Increased expression of proto-oncogence. B. Increased production of growth factors. C. Increased synthesis of extracellular matrix proteins. D. Increased afterload. E. Increased wall tension.,延尼逃净驺招芰睾欧南笳可退孥骇扫耽碍岈窃玖跪坫潆挪亘唣刺封疚玻嘈荷骼葶声樱阉拐剌镆把髂鬃楹抢氩喘严嘴垅鲁壮钌能肄诼嬉辉毗堞眙謦丧啭琚蝗诅绞浒诉耵嬉粉谣通怕豫杌浜董谡蜚魏慝蟋,renin,Angiotensinogen,Angiotensin I,Other pathways,Angiotensin II,Receptors,AT1,AT2,Vasoconstriction,Proliferative Action,Vasodilatati