新型血管内支撑物材料的药理学、毒理学实验.doc

:; :.SD.;. Keywords:biomaterial;vascularanastomosis;pharmacolo-gy;animal Abstract:AIMTostudytheeffectofthenewpatternback-stopusedinvascularNPBUVonanimalcirculationinspi-rationnerveactionandvascular.METHODSVariousdos-esofNPBUVanditssolutionweregiventoratsmiceandrabbitsandrelatedpharmacologicalandtoxicologicalstudywereperformed.RESULTSNPBUVsplacedinvascularhadnoeffectonthecirculationandrespirationofthemousein-cludingmeanarterypressuresystolicpressurediatolicpressureinspirationrate.Itssolutioninjectedinveinalsohadnotexcitingandrestrainingeffectsonrats.MoreoverbothNPBUVanditssolutionhadnoeffectsonbloodvesselsoftherabbitsnorNPBUVplacedinitsmesenteryhadanysignificantpathologicalchangesinitsinnermiddleandoutermembrane.CONCLUSIONNPBUVhasnoeffectsonani-malcirculationinspirationnerveactionandvesselsandsocanbeusedinlaservascularanastomoseasakindofnewma-terialplacedinbloodvessels. 0 1-4. 1 1.19806055.50g・L-1. 1.2SD825035g.80202g.161.80.3kg.08-01420140%50%12h. 1.3SD815g・L-1+13g・L-15mL・kg-1.30min5min1131030100mg・kg-1PAPSAPDAHRR. 1.4503.Control1050g・L-1.Caffeine1050mg・kg-1.3S1S2S310.101001000mg・kg-10.2mg・kg-1.GJ-8502. 1.5 1.5.1123250g・L-1520mL・kg-172h.LD50. 1.5.250g・L-1250g・L-120mL・kg-17d. 1.6 1.6.182450g・L-11mL・kg-11.5min.450mg・kg-11.5min.2.5cm4cm40g・L-1HE. 1.6.2830g・L-130mL・kg-14.7.810mL20min1cm40g・L-1HE. t. 2 2.1Tab1. 1 2.2Tab2. 2 2.320.5g・kg-1. 2.3.1.2.3.2. 3 .6.7.407.10100mg・kg-1. : 1ScherrDSPopasDP.LasertissueweldingJ.UrolClinNorthAm1998;251:123-125. 2BassLSTreatMR.Lasertissuewelding:Acomprehensivere-viewofcurrentandfutureclinicalapplicationsJ.LaserSurgMed1995;174:315-349. 3ChaiTChouCK.Mechanicalpropertiesoflaser-weldingcasttitaniumjointsunderdifferentconditionsJ.JProsthetDent1998;794:477-483. 4YangJQDuanXMLongKPWangSG.Themethodandin-strumentofcircularCO2lasermicrovascularanastomosisJ.JiguangZazhiJLaser1996;176:290-291. 5YangJQDuanXMWangDGYangJLongKP.Develop-mentofanewintravascularsupporterJ.Di-siJunyiDaxueXuebaoJFourthMilMedUniv1997;182:145. 6ZouBR.TheadvanceinlaservascularsutureingJ.PuwaiLinchuangJGeneralSurg1992;76:346-349. 7Zh