宫颈癌组织CD44v6表达的意义.doc

CD44v6 :CD44; :CD44v6.S-P6010CIN12CD44v6.CD44V620%CINCD44v642%CD44v668%.CD44v6CD44v643%69%85%P<0.05.CD44v691%52%P<0.05.CD44v6CD44v663%80%P>0.05.CD44v6CD44v6. Keywords:CD44;cervixneoplasms;immunohistochemistry Abstract:AIMToStudytheclinicalsignificanceofCD44v6expressionincervicalcancer.METHODSSpecimensof60cervicalcancer10normalcervicalepitheliaand12cervicalintraepithelialneoplasiaCINwereexaminedforCD44v6expressionbyimmunohistochemicalstaining.RESULTSPositivestainingwasseenin20%ofnormalcervicalepithe-lia42%ofCIN68%ofcervicalcancer.IncervicalcancerthefrequencyofabnormalCD44v6expressionwascorrelated topathologicgradeandlymphnodemetastasisP<0.05.Thehigherthepathologicgradeoftumorthemoretheex-pressionofCD44v6.PositiveCD44v6expressionwassignifi-cantlymorefrequentintheadvancedstageofcervicalcancerwithlymphnodemetastasis.CONCLUSIONDecreasedex-pressionofCD44v6isausefulparameterofcervicalmalig-nancy. 0 CD4412.v6CD44CD44v61.CD44v6. 1 1.11998/19994020.297049.142620.1129.10CIN12.CD44v6mAbSigmaS-PZymed. 1.2S-PDAB.PBS.:-:25%;+:26%50%;:51%75%;:76%. :2. 2 2.1CD44v6CD44v6CINFig120%42%68%Tab1CINCD44v6P<0.01. 1CD44v6 1CD44v6CIN 2.2CD44V6CD44v6P<0.05;CD44v6P<0.05Tab2;CD44V6P>0.05. 3 CD44-.CD441150kb19.CD442:CD44sCD44v.v6CD44CD44v63-5.CD44v6Gunthert.CD44v6.CD44v6.CD44v6.CD44v620%0.05.CD44v67. 260CD44v6 Stage40152562Stage2041680CD44v6.CD44v6CD44.CD44v6CD44v6.CD44v6CD44V6CD44v6.CD44v6k-rasp53.CD44v6.CD44v6.CD44v6CD44v6CD44v6.CD44v6. : 1LiXYHuJL.TheexpressionandClinicalsignificanceofCD44SandCD44v6ingastriccancerJ.Di-siJunyiDaxueXuebaoJFourthMilMedUniv1998;195:534. 2CaoWDZhangXLiuWPLiuFLiuXZWangZX.Ex-pressionofCD44inmeningiomasglioblastomasmultiformandbrainmetastasesJ.Di-siJunyiDaxueXuebaoJFourthMilMedUniv2000;2110:1292-1294. 3MorrisSFOHanlonDMMcLaughlinRMcHaleTConnol-lyGEGivenHF.TheprognosticsignificanceofCD44sandCD44v6expressinstagetwobreastcarcinoma:Animmunohis-tochemicalJ.EurJSurgOncol2001;276:527-531. 4WimmenauerSSteiertAWolff-VorbeckGXingBBaierPKRuckauerKDKirsteGvonKleistS.Influenceofcy-tokinesontheexpressionoffasligandCD44splicevariantsincoloncarcinomacellsJ.TumourBiol1999;206:294-303. 5WangJHChuXYChengLBZhuXJLongYL.StudiesontheexpressionsofCD44v6andC-erbB-2geneproductinhu-mannon-SmallcellLungCancerJ.ZhongliuFangzhiYanjuCancerResPrevTreat2000;273:191-193. 6DaraiEWalker-CombrouzeFBeniflaJL.E-cadherinandCD44expressionincervicalintraepithelialneoplasia:Compari-sonbetweenHIV-positiveandHIV-negativewomenandcorre-lationwithHPVstatusJ.GynecolOncol2000;761:56-62. 7KzinzCTempferCKohlbergerPJanischSKoelblHGitschGBreitenecke