2019年生物发酵产品目前能达到的水平参考大全.doc

生物发酵产品目前能达到的水平参考大全点击数：404 发布时间：2009年9月13日 来源： 进入论坛交流ITEMS TECH DATA REMARKSIMMUNOSUPPRESSIVE AGENT 他克莫司Tacrolimus Final Titre:600-700mg/LFermentation time:168hrsRecovery:40% FK506 霉酚酸Mycophenoic acid Final Titre:15g/LFermentation time:264hrsRecovery:70% Intermediatefor MMF 环孢菌素 ACyclosporin A Final Titre: 10g/LFermentation Time:168hrsRecovery:70% 雷帕霉素(西罗莫司)Rapamycin(Sirolimus) Final Titre: 600-800g/LFermentation Time:216hrsRecovery:60% Or intermediatefor Zotarolimus, Everolimus and 子囊霉素Ascomycin Final Titre: 500g/LFermentation Time:216hrsRecovery:60% FK520 Or Intermediate for PimecrolimusANTIBIOTICS 阿莫西林AMOXICILLINBy enzyme process 万古霉素Vancomycin Final Titre:9-10g/LFermentation Time: 150hrsRecovery:70% 替考拉宁Teicoplanin Final Titre:4-5g/LFermentation Time: 150hrsRecovery:70% 达托霉素Daptomycin Final Titre2.0g/LFermentation Time: 200hrsRecovery:40% Or cubicin 莫匹罗星Mupirocin Final Titre:4-5g/LFermentation Time:60-70hrsRecovery:75% Pneumocandin B0 Final Titre:1.7g/LFermentation Time: 11-12daysRecovery:60% Caspofungin 雷莫拉宁Ramoplanin Final Titre:3g/LFermentation Time: 200hrsRecovery:60% 普那霉素（原始霉素）Pristinamycin Final Titre:8/LFermentation Time: 150hrsRecovery:70% 克拉维酸（棒酸）Clavulanic acid Final Titre:6g/LFermentation Time:105hrsRecovery:55% 头孢菌素 C Cephalosporin C Final Titre:40g/LFermentation Time:168hrsRecovery:80% 各种头孢类中间体 青霉素GPenicillin G Final Titre:120000g/LFermentation Time:220hrsRecovery:80% 红霉素Erythromycin Final Titre:9-10g/LFermentation Time:156hrsRecovery:60% 依托红霉素、琥乙红霉素、地红霉素、罗红霉素、阿奇霉素和克拉霉素的中间体 去甲金霉素Demethylchlortetracycline (DMCT) Final Titre:16g/LFermentation Time:200hrsRecovery:75% Intermediate forMinocycline,Tigecylcine 林可霉素（洁霉素）Lincomycin Final Titre:9-10g/LFermentation Time:200hrsRecovery:80-90% 克林霉素中间体Clindamycin 杆菌肽Bacitracin Final Titre:1200U/mlFermentation Time:50-60hrsRecovery:95% Zinc Bacitracin forAnimal feed additive 那西肽Nosiheptide Final Titre:1700-2000U/mlFermentation Time:50hrsRecovery:95% Animal feed additive 两性霉素BAmphotericin B Final Titre:10000U/mlFermentation Time:130-140hrsRecovery:75% 阿维拉霉素（卑霉素）Avilamycin Final Titre:7-8g/LFermentation Time:268hrsRecovery:95% Animal feed additive 恩拉霉素Enramycin Final Titre:8-10g/LFermentation Time:260hrsRecovery:95% Animal feed additive 卡那霉素Kanamycin Final Titre:25g/LFermentation Time:240hrsRecovery:85% 卷曲霉素Capreomycin Final Titre:11000U/mlFermentation Time:150-160hrsRecovery:75% 庆大霉素CGentamicin C Final Titre:5-6g/LFermentation Time:14daysRecovery:75% 庆大霉素BGentamycin B Final Titre:1000Mmg/LFermentation Time:120-130hrsRecovery:75% 异帕米星（Isepamicin） 多粘菌素BPolymyxin B Final titre 2.5 g/lFermentation time 72 hrsRecovery yield 70% 粘杆菌素 EPolymyxin E Final titre 600000U/mlFermentation time 96 hrsRecovery yield 75% 泰乐菌素Tylosin Final titre 15000 U/lFermentation time 180 hrsRecovery yield 70% 巴龙霉素Paromomycin Final titre 8g/lFermentation time170 hrsRecovery yield 70% 制霉菌素Nystatin Final titre 300,000IU/mlFermentation time 280 hrsRecovery yield 85% 盐霉素Salinomycin Final titre 80g/lFermentation time 268 hrsRecovery yield 90% 金霉素Chlortetracycline Final titre 50g/lFermentation time 200 hrsRecovery yield 90% 四环素Tetracycline Final titre 40g/lFermentation time 200 hrsRecovery yield 90% 土霉素Oxytetracycline Final titre 40g/lFermentation time 200 hrsRecovery yield 90% 链霉素Streptomycin Final titre 28,000U/mlFermentation time 200 hrsRecovery yield 80% 利福霉素Rifamycin Final titre 30g/lFermentation time 220 hrsRecovery yield 75% 黄霉素Flavomycin Final titre 8g/lFermentation time 168 hrsRecovery yield 90% 截短侧耳素Pleuromutilin Final titre 14000U/mlFermentation time 300 hrsRecovery yield 80% 泰妙菌素Tiamulin 大观霉素Spectinomycin Final titre 7000-10000U/mlFermentation time 130-150 hrsRecovery yield 70% 莫能菌素Monensin 38000u/mlFinal titre 6500-8000U/mlFermentation time 140-170 hrsRecovery yield 70-80% 妥布霉素Tobramycin Final titre 6500-8000U/mlFermentation time 140-170 hrsRecovery yield 70-80% 安普霉素Apramycin Final titre 6500-8000U/mlFermentation time 140-170 hrsRecovery yield 70-80% 尼可霉素Nikkomycin Final titre 7-8 g/lFermentation time 70 hrsRecovery yield 80% 麦角酸Lysergic acid Final titre 7-8 g/lFermentation time 360 hrsRecovery yield 70% For cabergoline and nicergoline 夫西地酸Fusidic Acid Final titre 4-5 g/lFermentation time 200 hrsRecovery yield 40% 麦迪霉素Medimycin Final titre 18g/lFermentation time 200 hrsRecovery yield 75% 莫能菌素Monensin Final Titre:40000U/mlFermentation Time: 300hrsRecovery:95% 马杜霉素Maduramicin Final Titre:612000U/mlFermentation Time: 200hrsRecovery:95% 利福霉素RIFAMYCIN Final Titre:25g/LFermentation Time:240hrsRecovery:80% 磷霉素Fosfomycin 氯霉素Chloramphenicol 灰黄霉素Griseofulvin 螺旋霉素Spiramycin/Rovamycin Final Titre:6000U/mlFermentation Time: 160hrsRecovery:75% 小诺霉素Micronomicin 维吉尼亚霉素Virginmycin R&D 亮菌甲素（假蜜环菌素）Armillarisin a. 美贝霉素Milbemycin Seeking 莫西菌素Moxidectin 道拉菌素Doramectin 土拉霉素Tulathromvcin Seeking 米卡芬净micafungin R&D 阿尼芬净anidulafungin R&D Bio-PESTICIDE 阿维菌素Abamectin Final Titre:4.5g/lFlask:4.8-5.0g/LTime:240hrsRecovery:80% Including its derivatives 多杀菌素Spinosad Final Titre:12g/LFermentation Time:200-240hrsRecovery:80%Bio-pesticide 井冈霉素Validamycin Final Titre: 3-4g/LFermentation Time:60-70hrsRecovery:80% 春雷霉素Kasugamycin Final Titre: 8000-1000U/mlFermentation Time:192hrsRecovery80% 多抗霉素Polyoxin Final Titre: 5000U/mlFermentation Time:192hrsRecovery：80% 脱落酸Abscisic Acid (ABA) Final Titre:1.6g/LFermentation Time:70-72hrsRecovery:60-65% Plant hormoneBiopesticide 赤霉素Gibberellin (GA3) Final Titre:2.5-2.8g/LFermentation Time:150-160hrsRecovery:80% 中生霉素zhongshengmycin Final Titre:10g/LFermentation Time:1200hrsRecovery:80% 枯草芽孢杆菌Bacillus subtilis Final Titre6000U/mlFermentation Time:150-160hrsRecovery:80% 苏云金杆菌Bacillus thuringiensis Final Titre:5500g/mlFermentation Time:150-160hrsRecovery:80% 浏阳霉素Liuyangmycin 宁南霉素Ningnanmycin 链霉素streptomycin For agriculture ANTI-DIABETES 米格列醇Miglitol Final Titre:2g/LFermentation Time:70-72hrsRecovery:60-65%Synthesis:90% 阿卡波糖Acarbose Final Titre:5-6g/LFermentation T, ime:130-150hrsRecovery:30-40% 伏格列波糖Veglibose Chemical synthesis ANTI-TUMOR 柔红霉素Daunomycin Final Titre:1.5g/LFermentation Time:168hrsRecovery:67% For epirubicin, Idarubicin, doxorubicin 洋红霉素Carminomycin Final titre 0.15 g/lFermentation time 168 hrsRecovery yield 65% 偏端霉素Distamycin Final titre 2g/lFermentation time 120 hrsRecovery yield 52% 博莱霉素Bleomycin Final titre 4g/lFermentation time 168 hrsRecovery yield 70% 紫杉醇Paclitaxel Final titre 200mg/lFermentation time 120 hrsRecovery yield 50% 丝裂霉素CMitomycin C Final titre 1000mg/lFermentation time 200 hrsRecovery yield 50% 阿霉素Doxorubicin Chemical synthesis Or fermentation 棕霉素Bruneomycin Final titre 150mg/lFermentation time 144 hrsRecovery yield 60% 放线菌素DDactinomycin D Chemical synthesis 表阿霉素Epirubicin Chemical synthesis 伊达比星Idarubicin Chemical synthesis 吡柔比星Pirarubicin Chemical synthesisANTI-CARDIVASCULAR 洛伐他汀Lovastatin Final Titre:16g/LFermentation Time:168hrsRecovery:70% 美伐他汀Compactin Final Titre:10g/LFermentation Time:200-220hrs 普伐他汀Pravastatin Final Titre: 8.0g/lConversion rate:70%Cycle time: 120-144 阿托伐他汀Atorvastatin Chemical synthesis 瑞舒伐他汀Rosuvastatin Chemical synthesis 辛伐他汀Simvastatin Chemical synthesis 氟伐他汀Fluvastatin Chemical synthesisORGANNIC ACIDBiobased chemicals 衣康酸Itaconic Acid Acid:6%Cycle time:40-50hrsConversion:50%Fermentation data:1.4g/L/hr The product gets to Pfizer 柠檬酸Citric acid 莽草酸Shikimic Acid Titre: 25g/L L-乳酸L-Lactic acid Acid:16-18%Conversion rate; 90% 丙酮酸Pyruvic acid Titre:55-65g/LConversion rate:55-60%Fermentation time:60hrRecovery:70% 长链二元酸Long-chain dicarbxylic acid DCA13-18: 180g/L,Fermentation time:5-6days Bio-based products 1，3-丙二醇1,3-propandiol(PDO) Titre: 85g/LConversion rate:60%Productivity:1.2-1.4g/LH Chemical 2，3-丁二醇2,3-butandiol 50-65g/L By product from PDO 丁醇Butanol 20g/L 甘油Glycerol Titre:160g/lTime:78hrsProductivity:2g/LHMass conversion rate: 48.6% Chemical 丙烯酰胺Acrylamide Enzyme activity: 1 0g/mlAcrylonitrile consumption: 0.75t/tConversion rate: 99.9% Chemical 烟酰胺Nicotinamide Enzyme activity: 8g/mlNicotinonitrile consumption: 0.85t/tConversion rate: 99.999%Assay: 100% Chemical 羟基乙酸Hydroxyacetic acid Enzyme activity: 0.1g/mlGlycolonitrile consumption: 0.78t/tConversion rate: 99.9%Assay: 99.5% ( pharma grade) Chemical 黄原胶Xanthan Final Titre:5-6g/LFermentation Time:36hrsRecovery:80% 琥珀酸（丁二酸）Succinic acid 苹果酸Malic acid 牛磺酸Taurine 乙酸（醋酸）Acetic acid 聚羟基脂肪酸Polyhydroxyalkanoates (PHAs) degradable plastics 聚乳酸Polylactic acid, PLAVITAMIN AND CAROTENOID 维生素B2Vitamin B2 Final titre 30g/lFermentation time 72 hrsRecovery yield 80% 维生素B12Vitamin B12 Final titre 250mg/lTIME:180hrs 维生素CVitamin C Final titre 11-12g/lFermentation time 60 hrsConversion rate; 90% 番茄红素Lycopene Final Titre:1.0g/L 胡萝卜素Beta Carotene Final Titre:2.5-3.0g/LFermentation Time:72hrsRecovery:75-80% 虾青素Astaxanthin Final Titre:2g/L 维生素D2 Vitamin D2 Light reaction 维生素D3Vitamin D3 Light reaction 维生素AVitamin A chemical synthesis 维生素HVitamin H By fermentationOr chemical synthesis Biotin HORMONE Biotransformation Hormone 雄烯二酮Anostenedione(AD) Final titre 15 g/lFermentation time 200 hrsRecovery yield 75% Intermediate 雄二烯二酮androsta-1,4-diene-3,17-dione(ADD) Final titre 10 g/lFermentation time 200 hrsRecovery yield 72% Intermediate 泼尼松龙Prednisolone Finaltitre20g/L(Maximum 70g/L)time：5-8 hrsconversion: 97100 睾丸素Testosterone Final Titre 5g/L 去氢甲睾酮Methandrostenolone Final Titre 10g/L Pregna 1,4,9,17 acetate Final Titre 5g/L Pregna 1,2,9,21 Final Titre 5g/L 螺内酯SPIRONOLACTONE 依普利酮Eplerenone ANTISPETIC 异抗血酸D-isoascorbate Productivity:18-20g/L 那他霉素Natamycin Final Titre:8-10g/LFermentation Time:140-150hrs antiseptic 乳酸链球菌素Nisin Natural antiseptic HEALTHCARE 谷胱甘肽Glutathione(GSH) Titre: 5g/LBiomass:140g/LFermentation time 72 hrsRecovery yield 45% 辅酶Q10Coenzyme Q10 Final titre2.5-3.0 g/lFermentation time 96 hrsRecovery yield 60% 透明质酸Hyaluronic acid (HA) Final Titre:6-7g/LFermentation Time:20hrsRecovery:90% Best performance is 10g/L 花生四烯酸Arachidonic acid (AA) Final titre 9+1.5 g/lFermentation time 192hrsRecovery yield: 65% Food additivesHealthcare S-腺苷甲硫氨酸S-adenosylmethionine (SAMe) 二十二碳六烯酸Docosahexaenic Acid(DHA) Others 普鲁兰Pullulan Titre:60-70g/LConversion:60-70% 灵芝多糖Polysaccharide Final Titre: 1.5g/l Cordyceps.sinensis 赤藓糖醇Erythritol excipient Instant Active Yeast Food p