苯扎氯铵.doc

苯扎氯铵bn zh l nBenzalkonium Chloride本品为氯化二甲基苄基烃铵的混合物。按无水物计算，含烃铵盐（C22H40CIN）应为 95.0105.0。This product is the mixture of dimethyl benzyl ammonium chloride. Calculation by anhydrous, the C22H40CIN content shall be 95.0105.0. 【性状】 本品为白色蜡状固体或黄色胶状体；水溶液显中性或弱碱性反应，振摇 时产生多量泡沫。 本品在水或乙醇中极易溶解，在乙醚中微溶。Shape and properties:This product is a white waxy solid or yellow jelly; water solution is neutral or weak alkaline reaction, when shaking, a lot of foam will produce.This product is easy to dissolve in water or ethanol, slightly soluble in ether. 【鉴别】 (1) 取本品约0.2g，加硫酸1ml 使溶解，加硝酸钠0.1g，置水浴上加热 5 分钟，放冷，加水10ml与锌粉0.5g，置水浴上温热5 分钟，取上清液2ml，加5亚硝 酸钠溶液1ml ，置冰水中冷却，再加碱性萘酚试液3ml ，即显猩红色。 (2) 取本品，加水制成每1ml中含0.5mg的溶液，照分光光度法（附录 A）测定， 在257nm，262nm及269nm 的波长处有最大吸收。 (3) (3) 取本品1 水溶液10ml，加稀硝酸0.5ml ，即发生白色沉淀，滤过，沉淀能在 乙醇中溶解，滤液显氯化物的鉴别反应（附录）。 Identification:(1) Taking this product about 0.2g, with 1ml of sulfuric acid dissolving, adding sodium nitrate 0.1g, heating on the water bath for 5 minutes, adding 10ml and zinc powder 0.5g, water bath for 5 minutes, take the supernatant 2ml, adding 5% sodium nitrite solution 1ml, cooling in water, add alkaline naphthol solution 3ml, then scarlet will show. (2) Take this product, add water to make a solution containing 0.5mg per 1ml, according to the spectrophotometric method (Appendix IV A), at 257nm, 262nm and 269nm at the wavelength of maximum absorption.(3) Take this product 1% aqueous solution 10ml, add dilute nitric acid 0.5ml, that is, white precipitate, filtration, precipitation can be dissolved in ethanol, the reaction of chloride in the filtrate (Appendix III). 【检查】酸碱度：取本品0.5g，加水50ml使溶解，加溴甲酚紫溶液（取溴甲酚紫50mg，加0.1mol/L氢氧化钠溶液0.92ml与乙醇20ml使溶解，加水稀释至100ml）0.1ml，若溶液显黄色，用氢氧化钠滴定液（0.1mol/L）滴定；若溶液显蓝紫色，用盐酸滴定液（0.1mol/L）滴定，消耗的滴定液均不得过0.1ml。溶液的澄清度与颜色：取本品1.0g，加新沸放冷的水100ml使溶解，溶液应澄清无色；如显浑浊，与1号浊度标准液（附录 B）比较，不得更浓；如显色，与黄色2号标准比色液（附录 A第一法）比较，不得更深。水不溶物：取本品1.0g，加水10ml溶解后，不得显浑浊，不得有不溶物。氨化合物：取本品0.1g，加水5ml溶解后，加氢氧化钠试液3ml，加热煮沸，不得发生氨臭。水分：取本品，照水分测定法（附录 M第一法 A）测定，含水分不得过10.0%。炽灼残渣：取本品1.0g，依法检查（附录 N），遗留残渣不得过0.1%。Check:PH: take this product 0.5g, 50ml water to dissolve, with bromocresol purple solution (take bromocresol purple 50mg, plus 0.1mol/L 0.92ml 20ml sodium hydroxide solution and ethanol dissolved, diluted with water to 100ml 0.1ml), if the solution is yellow, with sodium hydroxide titration solution (0.1mol/L) titration; if the solution is blue purple, with hydrochloric acid titration solution (0.1mol/L) titration, titration solution consumption shall be exceeding 0.1ml.Clarity and color of solution: take this product 1.0g, add new boiled water 100ml to dissolve, the solution should be clear and colorless; significant turbidity, and 1 turbidity standard solution (Appendix B), must not be thicker; such as color, and Yellow No. 2 standard colorimetric solution (appendix the first method is A), shall not be deeper.Water insoluble: take this product 1.0g, add water 10ml dissolved, shall not be muddy, no insoluble matter.Ammonia compounds: take this product 0.1g, 5ml of water dissolved, adding sodium hydroxide solution 3ml, boiling, no ammonia smell.Water content: take this product, according to the determination of moisture content (Appendix VIII M A) determination of water containing not more than 10%.Residue: take this product 1.0g, according to inspection (Appendix VIII N), legacy residue shall not exceed 0.1%.【含量测定】 取本品约0.5g，精密称定，置烧杯中，用水35ml分次洗入250ml 分 液漏斗中，加0.1mol/L氢氧化钠溶液10ml与氯仿25ml，精密加入新制的5 碘化钾溶液 10ml，振摇，静置使分层，水层用氯仿提取3 次，每次10ml，弃去氯仿层，水层移入 250ml 具塞锥形瓶中，用水约15ml分3 次淋洗分液漏斗，合并洗液与水液，加盐酸40ml， 放冷，用碘酸钾滴定液(0.05mol/L) 滴定至淡棕色，加氯仿5ml ，继续滴定并剧烈振摇 至氯仿层无色，并将滴定的结果用空白试验校正。每1ml碘酸钾滴定液(0.05mol/L) 相 当于35.40mg 的C22H40CIN 。 Content determination:Take this product about 0.5g, precision said, the beaker of water washed into 35ml 250ml separatory funnel, plus 0.1mol/L 10ml sodium hydroxide solution and chloroform 25ml, adding 5% 10ml of potassium iodide solution precision, the new system of shaking, the static water stratification, extracted 3 times with chloroform, 10ml each time, abandoned go to the chloroform layer layer into 250ml conical flask with stopper, water is about 15ml 3 times leaching separation funnel with lotion and liquid water, hydrochloric acid 40ml, put cold with potassium iodate titration solution (0.05mol/L) titration to light brown, add chloroform and 5ml, and continue the titration vigorous shaking to chloroform layer of colorless then, the titration correction by blank test