细胞生物学授课计划-陈梅.doc

2007 2008 学年第2学期授课计划课程名称：细胞生物学授课班级：生技0601、生技0602学 时 数：48其中讲课：48实验：无课程设计：无其他：无执行的教学大纲（名称、制订日期）：细胞生物学课程教学大纲教材（名称、编著者、出版日期）Cell and Molecular BiologyGerald Karp主编、 2006年出版主要参考书：1）细胞生物学，王金发，2003，科学出版社2）医学细胞生物学，杨抚华，2003，科学出版社3）细胞生物学，翟中和，王喜忠，丁明孝，2000，高等教育出版社出版 4）数据库：学术期刊网、维普中刊数据库 (/) 5）外文免费全文数据库（）主讲教师：陈梅辅导教师：胡尚莲教研室主任（签字）：2008 年2月16日学期授课计划表周别授课顺序授课章节的内容摘要需要学时作业数量作业估计时间112Chapter 1Introduction to the Study of Cell Biology4360 min11.1 The Discovery of Cells0.51.2 Basic Property of Cells11.3 Two Fundamentally Different Classes of Cells0.521.4 Replacing Damaged Cells and Organs11.5 Viruses123Chapter 2 Techniques in Cell Biology2130 min2.1 The Light Microscope12.2 Transmission Electron Microscope2.3 Scanning Electron Microscope2.4 The use of Radioisotopes12.5 Cell Culture2.6 The Fractionation of a Cells Contents by Differential Centrifugation2345Chapter 3 The Structure and Function of the Plasma Membrane4490 min43.1 An overview of Membrane Functions3.1.1 Compartmentalization3.1.2 Scaffold for biochemical activities3.1.3 providing a selectively permeable barrier3.1.4 Transporting solutes3.1.5 Responding to external signal3.1.6 Intercellua interaction3.1.7 Energy transduction13.2 A Brief History of Studies on Plasma Membrane Structure3.3 The Chemical Composition of Membranes3.3.1 Membrane lipids3.3.2 Membrane carbohydrates13.4 The Structure and Functions of Membrane Proteins3.4.1 Internal membrane proteins3.4.2 studying the structure and properties of internal membrane proteins3.4.3 peripheral membrane proteins3.4.4 Lipid-anchored membrane proteins53.5Membrane Lipids and Membrane Fluidity3.5.1 The importance of membrane fluidity3.5.2 Maintaining membrane fluidity3.5.3 The asymmetry of membrane lipids3.5.4 lipids rafts13.6 The Dynamic Nature of the Plasma Membrane3.6.1 The diffusion membrane proteins after cell fusion3.6.2 Restriction of protein and lipid mobility 3.6.3 Membrane lipid mobility13.7 The Movement of Substances across Cell Membrane3.7.1 The energetics of solute movement3.7.2 Diffusion of substances through membranes3.7.3 The diffusion of water through membranes3.8 Occluding Junction, Anchoring Junction, and Communicating Junction.3-468Chapter 4 Communication and Interactions between Cells and Their Environment66120 min64.1 The Extracellular Space14.2 Second Messengers and G Protein-Coupled Receptors4.2.1 Signal transduction by G protein-coupled receptors4.2.2 The discovery of the second messenger:cyclic AMP4.2.3 Lipididerived second messengers4.2.4 The specificity of G protein-coupled receptors4.3 The Role of Calcium as an Intracellular Messenger:Regulation Calcium concentrations in plant cells174.4 Receptors Tyrosine Kinases-A Second Major Type of Signaling Pathway14.5 Signals That Originate from Contacts between the Cell Surface and the Substratum184.6 Convergence, Divergence, and Crosstalk among Different Signaling Pathways14.7 Other Signaling Pathways14.8 Interactions of Cells with Other Cells and with Noncellular Substrates 59-10Chapter 5 Cytoplasmic Membrane System: Structure, Function, and Membrane trafficking 4240 min95.1 An overview of the Endomembrane system15.2 The Endoplasmic Reticulum5.2.1 The smooth endoplasmic reticulum5.2.2 Functions of the rough endoplasmic reticulum5.2.3 From ER to the golgi complex5.2.4 The first step in vesicular transport5.3 The Golgi Complex5.3.1 Glycosylation in the golgi complex5.3.2 The movement of Materials through the golgi complex1105.4 Types of Vesicle Transport and Their Functions5.4.1 COPII-coated vesicles:transporting cargo from the ER to the golgi complex5.4.2 COPI-coated vesicles: transporting escaped proteins back to the ER5.4.3 Beyond the golgi complex :sorting proteins at the TGN5.4.4 Targeting vesicles to a particular compartment15.5 Lysosomes15.6 Plant Cell Vacuoles5.7 Cellular Uptake of Particles and Macromolecules6-85.8 Posttranslational Uptake of Proteins by Peroxisomes, Mitochondria, and Chloroplasts5.8.1 Uptake of proteins into peroxisomes5.8.2 Uptake of proteins into Mitochondrial5.8.3 Uptake of proteins into chloroplasts260 min 611Chapter 6 The Mitochondrion and Chloroplast24120 min6.1 Fundamental Structure and Function of Mitochondrion and Chloroplast16.2 Production of Mitochondrion and Chloroplast16-712-13Chapter 7 The cell Nucleus and Chromosomes4390 min7.1 Cell Nucleus1.57.2 Chromosomes: the physical carriers of the genes7.2.1 The discovery of chromosomes7.2.2 Chromosomes as the carriers of genetic information7.2.3 Genetic analysis in Drosophila7.2.4 Crossing over and recombination2.57-814-16Chapter 8 The Cytoskeleton and Cell Motility6590 min148.1 Microtubules8.1.1 Structure and composition8.1.2 Microtubule-associated proteins8.1.3 Microtubule as structural supports and organization8.1.4 Microtubules as agents of intracellular motility8.1.5 Motor proteins that traverse the Microtubular cytoskeleton2158.2 Intermediate Filaments8.2.1 Intermediate Filaments 8.2.2 Types and functions of intermediate filaments18.3 Microfilaments8.3.1 Microfilaments assembly and disassembly8.3.2 Myosin: the molecular motor for actin filaments1168.4 Muscle Contractility0.58.5 Nonmuscle Motility 8.5.1 Actin-binding proteins8.5.2 Examples of nonmuscles motility and contractility 1.59-1017-19Chapter 9 Cellular Reproduction65150 min179.1 The Cell Cycle9.1.1 Cell cycles in vivo9.1.2 Control o f the cell cycles2189.2 M Phase: Mitosis and Cytokinesis9.2.1 Prophase9.2.2 Prometaphase9.2.3 Metaphase9.2.4