中药成分代谢化学教学大纲.doc

课程教学大纲：teaching outline一、 课程性质和任务Nature and task of the course中药成分代谢化学是研究中药有效成分在动物及人体内代谢反应的一门学Chinese native medicine ingredient metabolic chemistry is the subject of researching Metabolic reactions of traditional Chinese medicines effective component in animals and humans body. 科。主要任务是：1.中药成分在机体内发生代谢反应的组织、器官、部位及The main task:代谢反应发生的条件。2.代谢产物的定量分析及原形成分和代谢产物在体The Tissue,organs,parts of Chinese herbal medicinals ingredients metabolic reactions in the body and the condition of the reactions内或某组织器官的动态变化。3.代谢反应的机理及代谢途径。4.代谢产物的Quantitative analysis of the metabolites and the dynamic changes of original components and metabolites in the body or some organs.3 The mechanismand metabolic pathway ofmetabolic reactions药效评价，新药的设计创新。5.代谢产物的提取分离、精制及结构测定。6.4pharmacodynamic evaluation of metabolic products and design innovation of new drugs.5 metabolic products extraction、separation、purification and structure determination新的代谢化学研究方法的探讨。6To explore thenew researching methodsofMetabolic chemistry二、 课程教学目标：Course Teaching target中药代谢化学是研究、整理提高祖国医药遗产的现代科学之一。Chinese native medicine ingredient metabolic chemistry is the one study of modern science that can research and arrange the legacy of traditional chinese medicine对阐明中药的有效性，探讨有效成分的作用原理，解释中药复方配伍的合理性，阐明中医辩证施治的科学内涵等都具有重要意义。It is very significant to elucidate the effectiveness of traditional Chinese medicine、to explore the function mechanism of effective components、to explain the rationality of compatibility of compound chinese medicine and to clarify the scientific connotation of traditional Chinese medicine.此外，也是中药成分药代动力学和生物利用度研究的基础和前提。In addition, it is the foundation and the premise of traditional chinese medicine composition of pharmacokinetics and bioavailability researching中药成分代谢化学的研究还为新的活性成分的发现、新药合成及新的前体药物的研制提供可贵的理论和实践的依据。The research of Chinese native medicine ingredient metabolic chemistry also provide valuable theory and practical basis for new active ingredients discoverying、new drugs composing and new pro-drugs development.为中药(复方)有效成分的药代动力学研究、中药制剂的生物利用度和生物等效性研究、中药毒性成分的血药浓度监测及安全性评价研究等提供方法和技术支持，为学生以后从事中药开发研制、分析检验，以及开展中药临床评价、指导临床应用等奠定基础。 It is also Provides methods andtechnical support for pharmacokinetics research of traditional chinese medicine(compound) effective components、for bioavailability and bioequiavailability research of Chinese drugs pharmaceutics and for Blood concentration monitoring and Study onsafety evaluation of Toxic ingredients of Chinese herbal medicine. And it lay the foundation for sudents to engage in traditional Chinese Medicines development、analysis、clinical evaluation and The clinical application of the guidance and so on.三、 教学大纲（章节目录）：Teaching program第一章 总论（2学时）The first chapter general(2 credit hours of coursework)掌握中药成分代谢化学的概念、任务和目的和意义及中药成分代谢反应类型。Master the concept,taskandmetabolism of chemicalcomponents of traditional Chinese medicineand traditional Chinese medicinecomposition ofthe purpose and significance ofmetabolicreactions.了解中药成分代谢化学与相关学科的关系。To investigate the relationship between thetraditional Chinese medicine compositionmetabolic chemistryand related disciplines第二章 （2学时）The second chapter general(2 credit hours of coursework)掌握生物膜的结构与功能、中药成分的吸收和分布。Master theabsorption and distribution ofthe structure and functionof biological membranes,the ingredients of Chinese medicine.熟悉中药成分的排泄。Familiar withChinese medicineexcretion第三章 影响中药成分代谢的因素（2学时）The third chapter The influence factorsof traditional Chinese medicinecompositionand metabolism(2 credit hours of coursework)掌握给药途径和制剂对中药成分代谢的影响，熟悉药物对中药成分代谢的影响。Understand the effect ofroute of administration andpreparationon traditional Chinese medicine compositionand metabolism,familiar with theeffects of drugs on themetabolism of Chinese Medicine.了解生物因素、食物对中药成分代谢的影响。understand the effect of biological factorsand food onthe metabolism of chinese medicine ingredients.第四章 中药成分在消化道内的代谢（4学时）The fourth chapter The metabolic of components of traditional Chinese medicinein the digestive tract. (4 credit hours of coursework)掌握中药成分在消化道内引起的代谢反应：化学介质及其代谢作用、微生物及其代谢作用肠粘膜及其代谢作用。Master themetabolic reactionscaused bytraditional Chinese medicine compositionin the digestive tract.熟悉中药成分在消化道内代谢研究方法。Familiar research method of metabolism of chinese medicine in the digestive tract.了解中药成分在消化道内引起的代谢反应类型：Understand thetype ofmetabolic reactioncaused bytraditional Chinese medicine compositionin the digestive tract.水解反应、还原反应、碳-硫键的裂解、芳香化反应、立体异构化反应、结合反应、开裂反应。The hydrolysis reaction, reduction reaction, carbon sulfur bond cracking, aromatization, three-dimensional isomerization, binding reaction, cracking reaction 第五章 中药成分在肝脏的代谢（2学时）The fifth chapter Traditional Chinese medicine compositionmetabolism in the liver (2 credit hours of coursework)掌握肝脏中的药酶系统及中药成分在肝脏中的药物代谢、结合反应。熟悉中药成分在肝内代谢的研究方法。Understand the Drugenzyme systemin the liver and drug metabolism and binding reaction of Chinese medicineingredients in the liver.第六章 中药成分在肺、肾、脑、血浆的代谢（2学时）The sixth chapter (2 credit hours of coursework)The metabolic of traditional chinese medicine components in the lung、kidney、brain and plasm熟悉中药成分在肺、肾、脑、血浆中的代谢及中药成分在肺肾脑等组织器官内代谢的研究方法Familiar with The metabolic of traditional chinese medicine components in the lung、kidney、brain and plasm and theresearch methods of it.第七章 中药成分代谢产物的分析（2学时）The seventh chapter (2 credit hours of coursework)Analysis of the metabolite of trad