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文文献献题题名名 1 Identification of Claudins by Western Blot and Immunofluorescence in Different Cell Lines and Tissues 2 Understanding the Role of Stromal PTEN Regulated miR 101 and miR 130b in Tumor Microenvironment 3Regulation of DMD pathology by an ankyrin encoded miRNA 4 A cytokine mixture of GM CSF and IL 3 that induces a neuroprotective phenotype of microglia leading to amelioration of 6 OHDA induced Parkinsonism of rats 5 Exome sequencing identifies MVK mutations in disseminated superficial actinic porokeratosis 6Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity 7 Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone Mediated Autophagy and Promotes Tumor Growth 8NDUFA4 Is a Subunit of Complex IV of the Mammalian Electron Transport Chain 9 Zinc Fingers and Homeoboxes 2 Inhibits Hepatocellular Carcinoma Cell Proliferation and Represses Expression of Cyclins A and E 10 p28GANK Prevents Degradation of Oct4 and Promotes Expansion of Tumor Initiating Cells in Hepatocarcinogenesis 11 Prostaglandin E Signaling and Bacterial Infection Recruit Tumor Promoting Macrophages to Mouse Gastric Tumors 12 RN181 suppressed tumor growth of hepatocellular carcinoma by inhibition of the ERK MAPK pathway 13 p28GANK Overexpression Accelerates Hepatocellular Carcinoma Invasiveness and Metastasis via Phosphoinositol 3 Kinase AKT Hypoxia Inducible Factor 1a Pathways 14Brain derived neurotrophic factor contributes to abdominal pain in irritable bowel syndrome 15 Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways 16 Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload 17 D peptide inhibitors of the p53 MDM2 interaction for targeted molecular therapy of malignant neoplasms 18The oncoprotein p28GANK establishes a positive feedback loop in catenin signaling 19 Lithium an anti psychotic drug greatly enhances the generation of induced pluripotent stem cells 20 Egr 1 decreases adipocyte insulin sensitivity by tilting PI3K Akt and MAPK signal balance in mice 21NFIL3 E4BP4 controls type 2 T helper cell cytokine expression 22IKK mediates hydrogen peroxide induced cell death through p85 S6K1 23 Urine proteome analysis reflects atherosclerotic disease in an ApoE mouse model and allows the discovery of new biomarkers in mouse and human atherosclerosis 24Does insulin bolster antioxidant defenses via the ERK Akt Nrf2 pathway 0 25 Osteogenesis and angiogenesis induced by porous CaSiO3 PDLGA composite scaffold via activation of AMPK ERK1 2 and PI3K Akt pathways 26 Endothelial cells dysfunction induced by silica nanoparticles through oxidative stress via JNK P53 and NF kB pathways 27 An epidermal stem cells niche microenvironment created by engineered human amniotic membrane 28 The combined effects of continuous passive motion treatment and acellular PLGA implants on osteochondral regeneration in the rabbit 29 PDK1 Regulates Vascular Remodeling and Promotes Epithelial Mesenchymal Transition in Cardiac Development 30 MicroRNA 214 downregulation contributes to tumor angiogenesis via inducing secretion of hepatoma derived growth factor in human hepatoma 31 New insights into the antifi brotic effects of sorafenib on hepatic stellate cells and liver fi brosis 32 p53 insensitive PUMA down regulation is essential in the early phase of liver regeneration after partial hepatectomy in mice 33Profiling of the BRCA1 transcriptome through microarray and ChIP chip analysis 34A novel XPF 357A C polymorphism predicts risk and recurrence of bladder cancer 0 35 Hippocampal Neuronal Nitric Oxide Synthase Mediates the Stress Related Depressive Behaviors of Glucocorticoids by Downregulating Glucocorticoid Receptor 36MFG E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation 37 IRX1 influences peritoneal spreading and metastasis via inhibiting BDKRB2 dependent neovascularization on gastric cancer 38Nanofiber scaffolds facilitate functional regeneration of peripheral nerve injury 39HOXB7 as a prognostic factor and mediator of colorectal cancer progression 40 Age related changes in rostral basal forebrain cholinergic and GABAergic projection neurons relationship with spatial impairment 41 Epigenetic Regulation of DACT2 A Key Component of the Wnt Signaling Pathway in Human Lung Cancer 42 Endostatin inhibits tumour lymphangiogenesis and lymphatic metastasis via cell surface nucleolin on lymphangiogenic endothelial cells 43 Reduced expression of MUTYH with suppressive activity against mutations caused by 8 hydroxyguanine is a novel predictor of a poor prognosis in human gastric cancer 44 Up regulated miR 17 promotes cell proliferation tumour growth and cell cycle progression by targeting the RND3 tumour suppressor gene in colorectal carcinoma 0 45 Construction of a Portal Implantable Functional Tissue Engineered Liver Using Perfusion Decellularized Matrix and Hepatocytes in Rats 46 Cellular FLICE inhibitory protein protects against cardiac remodelling after myocardial infarction 47 Toll like receptor 4 signaling promotes epithelial mesenchymal transition in human hepatocellular carcinoma induced by lipopolysaccharide 48 UXT V1 protects cells against TNF induced apoptosis through modulating complex II formation 49 Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt b Catenin Signaling 50 T63 a New 4 Arylidene Curcumin Analogue induces cell cycle arrest and apoptosis through activation of Reactive Oxygen Species FOXO3a pathway in lung cancer cells 51 ROS activated p38 MAPK ERK Akt cascade plays a central role in palmitic acid stimulated hepatocyte proliferation 52PGD2 and PGE2 regulate gene expression of Prx 6 in primary macrophages via Nrf2 53 TRAIL and doxorubicin combination enhances anti glioblastoma effect based on passive tumor targeting of liposomes 54 Expression of PDGFR in colorectal cancer stroma and the relationship to lymphangiogenesis 55 Aldehyde Dehydrogenase 2 Deficiency Aggravates Cardiac Dysfunction Elicited by Endoplasmic Reticulum Stress Induction 56 Grainyhead like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3 claudin4 and Rab25 57Shp2 Plays an Important Role in Acute Cigarette Smoke Mediated Lung Inflammation 58 Nuclear to Cytoplasmic Translocation of Heterogeneous Nuclear Ribonucleoprotein U Enhances TLR Induced Proinflammatory Cytokine Production by Stabilizing mRNAs in Macrophages 59 Identification of Resting and Type I IFN Activated Human NK Cell miRNomes Reveals MicroRNA 378 and MicroRNA 30e as Negative Regulators of NK Cell Cytotoxicity 60The toxicity evaluation of nano trititanate with bactericidal properties in vitro 61 Quantitative proteomics using stable isotope labeling with amino acids in cell culture SILAC reveals protein and pathway regulation in porcine circovirus type 2 infected PK 15 cells 62 miR 181a b significantly enhances drug sensitivity in chronic lymphocytic leukemia cells via targeting multiple anti apoptosis genes 63 MicroRNA 622 functions as a tumor suppressor by targeting K Ras and enhancing the anticarcinogenic effect of resveratrol 64MiR 145 inhibits tumor angiogenesis and growth by N RAS and VEGF 65 MiR 138 suppressed nasopharyngeal carcinoma growth and tumorigenesis by targeting the CCND1 oncogene 66Checkpoint kinase 1 is essential for meiotic cell cycle regulation in mouse oocytes 67 The retinoblastoma protein selectively represses E2F1 targets via a TAAC DNA element during cellular senescence 68 Roles of the KRAB associated co repressor KAP1 S473 phosphorylation in DNA damage response 69Slit2 Regulates the Dispersal of Oligodendrocyte Precursor Cells via Fyn RhoA Signaling 70 Disturbance of Ca2 Homeostasis Converts Pro Met into Non canonical Tyrosine Kinase p190MetNC in Response to Endoplasmic Reticulum Stress in MHCC97 Cells 71 Trio Is a Key Guanine Nucleotide Exchange Factor Coordinating Regulation of theMigration andMorphogenesis of Granule Cells in the Developing Cerebellum 72 Heme Oxygenase 1 Carbon Monoxide Induces Vascular Endothelial Growth Factor Expression via p38 Kinase dependent Activation of Sp1 73 The protease allergen Pen c 13 induce allergic airway inflammation and changes in epithelial barrier integrity and function in a murine model 74 Protein Kinase C Promotes NMDA Receptor Trafficking by Indirectly Triggering CaMKII Autophosphorylation 75 Distinct kinetic and spatial patterns of PKC and EGFR dependent activation of extracellular signal regulated kinases 1 and 2 by humane nicotinic acid receptor GPR109A 76 AKT2 suppresses GAPDH mediated apoptosis in ovarian cancer cells via phosphorylating GAPDH at threonine 237 and decreasing its nuclear translocation 77 MicroRNA 99a Inhibits Hepatocellular Carcinoma Growth and Correlates with Prognosis of Patients with Hepatocellular Carcinoma 78 Aurora B Interaction of Centrosomal Nlp Regulates Cytokinesis 0 79 SHAFTS A Hybrid Approach for 3D Molecular Similarity Calculation 2 Prospective Case Study in the Discovery of Diverse p90 Ribosomal S6 Protein Kinase 2 Inhibitors To Suppress Cell Migration 80 Exogenous melatonin modulates apoptosis in the mouse brain induced by high LET carbon ion irradiation 0 81 Cellular Pharmacokinetic Mechanisms of Adriamycin Resistance and Its Modulation by 20 S Ginsenoside Rh2 in MCF 7 Adr Cells 0 82Inhibition of autophagy enhances anticancer effects of bevacizumab in hepatocarcinoma 83 Functionalized single walled carbon nanotubes cause reversible acute lung injury and induce fibrosis in mice 84Disruption of mindin exacerbates cardiac hypertrophy and fibrosis 85 Comparative Proteomic Analysis of Differentially Expressed Proteins between Peripheral Sensory and Motor Nerves 86 Slow skeletal muscle myosin binding protein C MyBPC1 mediates recruitment of muscle type creatine kinase CK to myosin 87 Metallothioneins Protect Cytosolic Creatine kinases Against Stress Induced by Nitrogen Based Oxidants 88 Silencing of hHS6ST2 inhibits progression of pancreatic cancer through inhibition of Notch signaling 89 Omega 3 docosahexaenoic acid and procyanidins inhibit cyclooxygenase activity and attenuate NF B activation through a p105 p50 regulatory mechanism in macrophage inflammation 90 Up regulated miR 17 promotes cell proliferation tumor growth and cell cycle progression by targeting RND3 tumor suppressor gene in colorectal carcinoma 91 The preparation of functionalized graphene oxide for targeted intracellular delivery of siRNA 92 Human urinary kallidinogenase suppresses cerebral inflammation in experimental stroke and downregulates nuclear factor B 93 Riccardin D 26 a synthesized macrocyclic bisbibenzyl compound inhibits human oral squamous carcinoma cells KB and KB VCR In vitro and in vivo studies 94 ERK MAPK Signaling Opposes Rho Kinase to Reduce Cardiomyocyte Apoptosis in Heart Ischemic Preconditioning 95 Defects in cytokine mediated neuroprotective glial responses to excitotoxic hippocampal injury in senescence accelerated mouse 96Targeted mutation of Fas ligand gene attenuates brain inflammation in experimental stroke 97 Comparing the effects of nano sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice 98 Second generation aptamer conjugated PSMA targeted delivery system for prostate cancer therapy 99 Activation of neurokinin 1 receptor by substance P inhibits melanogenesis in B16 F10 melanoma cells 100 Up regulating ribonuclease inhibitor inhibited epithelial to mesenchymal transition and metastasis in murine melanoma cells 101 Small interfering RNA targeting integrin linked kinase inhibited the growth and induced apoptosis in human bladder cancer cells 102 H1 a derivative of Tetrandrine exerts anti MDR activity by initiating intrinsic apoptosis pathway and inhibiting the activation of Erk1 2 and Akt1 2 103 MicroRNA 409 3p regulates cell proliferation and apoptosis by targeting PHF10 in gastric cancer 104 Opsin3 sensitizes hepatocellular carcinoma cells to 5 fluorouracil treatment by regulating the apoptotic pathway 105 SDF 1 CXCR4 signaling induces pancreatic cancer cell invasion and epithelial mesenchymal transition in vitro through non canonical activation of Hedgehog pathway 106 Inhibition of activated Stat3 reverses drug resistance to chemotherapeutic agents in gastric cancer cells 107 Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo 108 LCH 7749944 a novel and potent p21 activated kinase 4 inhibitor suppresses proliferation and invasion in human gastric cancer cells 109 Identification of urinary Gc globulin as a novel biomarker for bladder cancer by two dimensional fluorescent differential gel electrophoresis 2D DIGE 110 HnRNPL as a key factor in spermatogenesis Lesson from functional proteomic studies of azoospermia patients with sertoli cell only syndrome 0 111 Interactome study suggests multiple cellular functions of hepatoma derived growth factor HDGF 112 ER Mediated Estradiol Enhances Epithelial Mesenchymal Transition of Lung Adenocarcinoma through Increasing Transcription of Midkine 113 LYG 202 Augments Tumor Necrosis Factor induced Apoptosis Via Attenuating CK2 dependent Nuclear Factor B Pathway in HepG2 Cells 114 The use of layer by layer self assembled coatings of hyaluronic acid and cationized gelatin to improve the biocompatibility of poly ethylene terephthalate artificial ligaments for the reconstruction of anterior cruciate ligament 115Negative regulation resistant p53 variant enhances oncolytic adenoviral gene therapy 116 The proteomic study on cellular responses of the testes of zebrash Danio rerio exposed to microcystin RR 117 Synchronized Activity of Organic Cation Transporter 3 Oct3 Slc22a3 and Multidrug and Toxin Extrusion 1 Mate1 Slc47a1 Transporter in Transplacental Passage of MPP in Rat 118 Loss of A1 Adenosine Receptor Attenuates Alpha naphthylisothiocyanate induced Cholestatic Liver Injury in Mice 119 Mitochondrial Prohibitins and Septin 9 Are Implicated in the Onset of Rat Hepatocarcinogenesis 120 miR 106a mediated Malignant Transformation of Cells Induced by Anti benzo a pyrene trans 7 8 diol 9 10 epoxide 121 Increase of Anteroventral Periventricular Kisspeptin Neurons and Generation of E2 Induced LH Surge System in Male Rats Exposed Perinatally to Environmental Dose of Bisphenol A 122 Common genetic variants on 8q24 contribute to susceptibility to bladder cancer in a Chinese population 123 Human Umbilical Cord Stem Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Immunoinflammation and Remyelination 124Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis 125 5 Azacytidine Induces Cardiac Differentiation of Human Umbilical Cord Derived Mesenchymal Stem Cells by Activating Extracellular Regulated Kinase 0 126 Smad4 disruption accelerates keratinocyte reepithelialization in murine cutaneous wound repair 127miR 200b regulates cell migration via Zeb family during mouse palate development 128 Insulin like growth factor 1 enhances the proliferation and osteogenic differentiation of human periodontal ligament stem cells via ERK and JNK MAPK pathways 129 Adenoviral mediated RNA interference targeting URG11 inhibits growth of human hepatocellular carcinoma 130miR 181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines 131 Lymphatic endothelial cell secreted CXCL1 stimulates lymphangiogenesis and metastasis of gastric cancer 132 A novel BH3 mimetic S1 potently induces Bax Bak dependent apoptosis by targeting both Bcl 2 and Mcl 1 0 133 Chronic noise exposure causes persistence of tau hyperphosphorylation and formation of NFT tau in the rat hippocampus and prefrontal cortex 134 Microcystin LR Induces Ceramide to Regulate PP2A and Destabilize Cytoskeleton in HEK293 Cells 135 Hypoxia inducible factor 1 mediated human GATA1 induction promotes erythroid differentiation under hypoxic conditions 136 p53 suppresses lung resistance related protein expression through Y box binding protein 1 in the MCF 7 breast tumor cell line 137Positive and negative regulation of insulin action by genistein in the endothelium 138 Maternal low protein diet causes epigenetic deregulation of HMGCR and CYP7 1 in the liver of weaning piglets 139 mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo 140 Investigation of elemene induced reversal of tamoxifen resistance in MCF 7 cells through oestrogen receptor ER re expression 141Inhibition of herpes simplex virus infection by oligomeric stilbenoids through ROS generation 142MEK1 ERKs signal cascade is required for the replication of Enterovirus 71 EV71 143 Local hyperthermia could induce antiviral activity by endogenous interferon dependent pathway in condyloma acuminata 144Houttuynia cordata blocks HSV infection through inhibition of NF kB activation 145 Cardioprotective Effect of Paeonol and Danshensu Combination on Isoproterenol Induced Myocardial Injury in Rats 146 Evaluation of Dermal Substitute in a Novel Co Transplantation Model with Autologous Epidermal Sheet 147RhoC Regulates the Proliferation of Gastric Cancer Cells through Interaction with IQGAP1 148 Luteolin Induces Carcinoma Cell Apoptosis through Binding Hsp90 to Suppress Constitutive Activation of STAT3 149 L Carnitine Is an Endogenous HDAC Inhibitor Selectively Inhibiting Cancer Cell Growth In Vivo and In Vitro 150 Angiotensin 1 7 in Paraventricular Nucleus Modulates Sympathetic Activity and Cardiac Sympathetic Afferent Reflex in Renovascular Hypertensive Rats 151 Silencing Prion Protein in MDA MB 435 Breast Cancer Cells Leads to Pleiotropic Cellular Responses to Cytotoxic Stimuli 152 miR 511 and miR 1297 Inhibit Human Lung Adenocarcinoma Cell Proliferation by Targeting Oncogene TRIB2 153 Proteomic Analysis

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