全球主要“LC-MS”生产厂商及其产品比较一览.doc

全球主要“LC-MS”生产厂商及其产品比较一览SupplierSystemType mass-analyserMass (m/z)-rangeLC-MS interfacesData-acquisition and processing softwareCompatibility in control of LC-systemsRemarksAgilent TechnologiesAgilent-1100 LC-MSD VL en SLSingle-quadrupole50-3000ESI, nano-ESI, APCI, APPILC/MSD, integrated with Agilent-3D LC ChemStationAgilent 1100 and CE systemAgilent TechnologiesAgilent-1100 LC-MSD-Trap VL en SLIon-trap50-2200 (tot 4000 met extended mass range)ESI, nano-ESI, APCI, APPI, AP-MALDILC/MSD trap, integrated with Agilent-3D LC ChemStationAgilent 1100 and CE systemAmersham BiosciencesEttan (micro)LC-MSTOF20 - 20.000ESIone software platform for controlling, acquisition, evaluating data obtained by MS and LC.MW 150.000 d (from small peptides to large megadalton complexes); integrated column switching for on-line sample cleanup, desalting, and concentration. 10E4 linear dynamic rangeApplied BiosystemsAPI-150EX TM LC/MS Systemsingle-quadrupole3000(Micro- and Turbo-) IonsprayTM source, APCI TM source, nanosprayANALYST TM Software (WindowsNT), Add on tools: IDA (Information Dependent Acquisition). Automaton, Metabolite IDPE Series 200, Agilent Series1100 and CapLC, Shimadzu LC-10A and LC-8A, Gilson Autosamplers,CTC Pal autosampler, Harvard Syringe pump, Spark Endurance autosampler, LC Packings UltimateAlso available as complete Discovery and Prep Workstation with required softwareApplied BiosystemsAPI-2000TM , API-3000TM and API-4000TM LC/MS/MS Systemtriple-quadrupole1800 (API-2000); 3000 (API-3000 and API-4000)(Micro- and Turbo-) Ionspray, APCI, nanospray for API-2000 and API 3000, Turbo V source, Ionspray, APCI for API-4000ANALYST (WindowsNT), Add on tools: IDA (Information Dependent Acquisition). Automaton, Metabolite IDMS-MS with LINAC collision cell, API-3000 and 4000 with additional sensitivityApplied BiosystemsQSTAR Pulsar i TM LC/MS/MS Systemquadrupole-time-of-flight hybrid12000(Micro- and Turbo-) Ionspray, APCI, nanospray, PhotoSprayANALYST (WindowsNT), Add on tools: IDA (Information Dependent Acquisition). Automaton, Metabolite ID, BioAnalyst, Pro-ID, Pro-ICATMS-MS with high resolution in MS2. With LINAC (PULSAR) collision cell. Mass accuracy 5 ppm, differential expression studies. Also MALDI-source available.Applied BiosystemsQTRAP TM LC-MS/MS Systemquadrupole-linear ion trap hybrid1800(Micro- and Turbo-) Ionspray, APCI, nanosprayANALYST (WindowsNT), Add on tools: IDA (Information Dependent Acquisition). Automaton.With LINAC collision celll. Qualitative- and quantitative analysis on an instrument with extended Scan functionality: Enhanced MS (EMS), MS3, Enhanced Resolution (ER), Enhanced Product Ion (EPI), Enhanced Multiply Chrg.(EMC), Timed Delayed FragmentationSpecial Metabolite-ID and Proteomics systems availableBruker DaltonikEsquire 2000Ion-trap2200ESI, APCIWindows 2000 based ESQUIRE-NT 5.0, HYSTAR LC control, Agilent ChemStation integrated for 1100 series HPLC and 3D CE control, data-dependent acquisition with ActiveExclusion, SmartFrag, SelectFrag, AutoMaxRes Mode; Windows post-processing modules QuantAnalysis, LibrarySearch, ACD (Structure Editor), MetaboliteTools (Metabolite identification)Agilent 1100MSn (n=3), Auto-MS/MS2, mono-isotopic isolation for m/z 2200, benchtop with small footprint, separate rough pump in noise dampled cabinet; patented orthogonal sprayer,on- and off-line Nano-ESIGrounded needle (CE/MS),On-line nanospray, AP MALDIBruker DaltonikEsquire 3000plusIon-trap6000;up to 3000 with variable scan speed and resolutionUltrasensitive ESI, APCI, on- and off-line Nano-ESI, APPIAgilent 1100, Waters, LC Packings UltimateMSn(n=11), Auto-MS/MS3, fast polarity switching ( 300 ms), mono-isotopic isolation for m/z 10,000 m/zESI, APCI,HyStar LC control; X-MASS-NT 4.0/ win2000 (acquisition, processing, plotting and analysis) Biotools (proteins) MASCOT (database search)Agilent 1100, Waters, LC Packings UltimateMass accuracy 20000; Dual-spray for calibration. Compass multipass-reflectron, AP-MALDI source. Upgradeable to Bio-TOF QNano-ESIBruker DaltonikBio-TOF QQuadrupole-time-of-flight (ESI-Q-q-TOF with Multipass reflectron) 10,000 m/zESI, APCI,HyStar LC control; X-MASS-NT 4.0/ win2000 (acquisition, processing, plotting and analysis) Biotools (proteins) MASCOT (database search)Agilent 1100, Waters, LC Packings UltimateQuadrupole ptrecursor mass selector to m/z 4000, Mass accuracy 20000; Dual-electrospray for calibration. Compass multipass-reflectron, AP-MALDI sourceNano-ESIBruker DaltonikAPEX IVFourier Transform Ion-cyclotron Resonance 15,000 m/zESI, APCI, Nano-ESI, EI, CI, SIMS, and MALDIHyStar LC control; X-MASS-NT 4.0/ win2000 (acquisition, processing, plotting and analysis) Biotools (proteins) MASCOT (database search)Agilent 1100, Waters, LC Packings UltimateInfinity Cell, Mass accuracy 2.000.000, MSn (n10000APCI, ESI, Frit-FAB, nanoflowJeol software (Windows)Agilent-1090 en 11005000 Resolution, Benchtop Model, Full Automatic Probe Analysis, MS/MS Linked scanJEOL (EUROPE) B.V.Mstation JMS-700magnetic sector, double focusing25000APCI, ESI, Frit-FAB, nanoflowJeol softwareAgilent-1090 en 110060000 resolutionJEOL (EUROPE) B.V.AccuTOFTOF10000ESI,APCI, Nano Flow, Corona ESIJeol software (Windows)Agilent-1090 en 1100High Dynamic Range, High Resolution, High SensitivityMicromassLCTtime-of-flightExceeding 20000Z-spray; ESI, APcI, Nanoflow Picospray and CE-MS interfaces, LockSpray; Multiplexed Electrospray 2,4 or 8 channel MUX option, with Lockmass.MassLynx 4.0 (Windows XP, NT or Windows 2000), MassLynx is CFR 21 part 11 complaint.; various integrated couplings to: pd-quest, ACD, nugenesisMicomass CapLC, Waters CapLC,Waters Alliance,Waters 600, Waters Breeze, Agilent 1050, 1090, 1100, JASCO, Gilson, Shimadzu and specific injectors like CTC PAL.Bench-top Mass accuracy: 5 ppm over m/z 150-900. 5000 resolution.MicromassQuattro-Microtriple-quadrupool1800Z-spray; ESI, APcI Nanoflow Picospray en CE-MS interfaces, LockSpray; 4 kanaals MUX optie beschikbaarMassLynx 4.0 (Windows XP, NT or Windows 2000), MassLynx is CFR 21 part 11 complaint.; various integrated couplings to: pd-quest, ACD, nugenesisMicomass CapLC, Waters CapLC,Waters Alliance,Waters 600, Waters Breeze, Agilent 1050, 1090, 1100, JASCO, Gilson, Shimadzu and specific injectors like CTC PAL.Bechtop MS/MSMicromassQuattro-Ultima-Pttriple-quadrupool4000Z-spray; ESI, APcI Nanoflow Picospray en CE-MS interfaces, LockSpray; 4 kanaals MUX optie beschikbaarMassLynx 4.0 (Windows XP, NT or Windows 2000), MassLynx is CFR 21 part 11 complaint.; various integrated couplings to: pd-quest, ACD, nugenesisMicomass CapLC, Waters CapLC,Waters Alliance,Waters 600, Waters Breeze, Agilent 1050, 1090, 1100, JASCO, Gilson, Shimadzu and specific injectors like CTC PAL.Bechtop MS/MS, iontunnel collision cellMicromassQ-TOF-Microquadrupool-vluchtijd hybrideExceeding 20000Z-spray; ESI, APcI Nanoflow Picospray en CE-MS interfaces, LockSpray; 4 kanaals MUX optie beschikbaarMassLynx 4.0 (Windows XP, NT or Windows 2000), MassLynx is CFR 21 part 11 complaint.; various integrated couplings to: pd-quest, ACD, nugenesisMicomass CapLC, Waters CapLC,Waters Alliance,Waters 600, Waters Breeze, Agilent 1050, 1090, 1100, JASCO, Gilson, Shimadzu and specific injectors like CTC PAL.Bench-top Hybrid MS-MS. Mass accuracy: 5 ppm over m/z 150-900. 5000 resolution.MicromassQ-TOF-Ultima APIquadrupool-vluchtijd hybrideExceeding 20000Z-spray; ESI, APcI Nanoflow Picospray en CE-MS interfaces, LockSpray; 4 kanaals MUX optie beschikbaarMassLynx 4.0 (Windows XP, NT or Windows 2000), MassLynx is CFR 21 part 11 complaint.; various integrated couplings to: pd-quest, ACD, nugenesisMicomass CapLC, Waters CapLC,Waters Alliance,Waters 600, Waters Breeze, Agilent 1050, 1090, 1100, JASCO, Gilson, Shimadzu and specific injectors like CTC PAL.Hybrid MS-MS. Mass accuracy: 5 ppm over m/z 150-900. In V-mode 10000 resolution; in W mode 20000 .MicromassQ-TOF-Ultima GLOBALquadrupool-vluchtijd hybrideExceeding 20000Z-spray; ESI, APcI Nanoflow Picospray en CE-MS interfaces, LockSprayMassLynx 4.0 (Windows XP, NT or Windows 2000), MassLynx is CFR 21 part 11 complaint.; various integrated couplings to: pd-quest, ACD, nugenesisMicomass CapLC, Waters CapLC,Waters Alliance,Waters 600, Waters Breeze, Agilent 1050, 1090, 1100, JASCO, Gilson, Shimadzu and specific injectors like CTC PAL.Hybrid MS-MS. Mass accuracy: 5 ppm over m/z 150-900. In V-mode 10000 resolution; in W mode 17500 . Maldi-optionMicromassAutoSpecSectorvanaf 3000ESI, APCIMassLynx 4.0 (Windows XP, NT or Windows 2000), MassLynx is CFR 21 part 11 complaint.; various integrated couplings to: pd-quest, ACD, nugenesisMicomass CapLC, Waters CapLC,Waters Alliance,Waters 600, Waters Breeze, Agilent 1050, 1090, 1100, JASCO, Gilson, Shimadzu and specific injectors like CTC PAL.Resolution 60000 (20% valley)ShimadzuQP-8000 alphasingle-quadrupole1500-2000ESI, APCILCMS solutions (windows NT, 2000) Shimadzu LC-10Avp, integrated systemVery robust system for routine analyses.ShimadzuLCMS2010 prepSTARsingle-quadrupole with Q-array technology2000ESI, APCILCMS solutions (windows NT, 2000) & Psiport MS datamanagement Shimadzu LC-8A, integrated system with optional Gilson 215 controlFlow rates: 0,1 to 150 ml/min, Mass Triggered fraction collector with sample tracking and PsiShimadzuLCMS 2010single-quadrupole with Q-array technology2000ESI, APCILCMS solutions (windows NT, 2000) & Psi port MS datamanagement Shimadzu LC-10Avp, integrated system with SILHT high throughput autosamplerpatented optical design; QoQ= Q-array (Tapered triple quadruplate), optical lens, Quadrupole.Thermo FinniganMSQSingle-quadrupole2000ESI, APCI (aQa-bron)Xcalibur (Windows 2000)TSP, Agilent and Waters (also LC-Packings, Spark, Gilson en CTC)Thermo FinniganLCQ Advantage and DecaXPIon-trap2000 (Advantage); 4000 (DecaXP)ESI, APCI, APPI, MALDI, Nano-ESIXcalibur (Windows 2000)TSP, Agilent and Waters (also LC-Packings, Spark, Gilson en CTC)MS-MS or optinal MS-MSn (Advantage) or MS-MSn (DecaXP)Thermo FinniganTSQTriple- quadrupole (TSQ)4000ESI, APCI, Nano-ESIXcalibur (Windows 2000)TSP, Agilent and Waters (also LC-Packings, Spark, Gilson en CTC)Also GC-MS, Solids-probe option and FAB; MS-MSThermo FinniganTSQ-QuantumTriple- quadrupole (TSQ)1500ESI, APCIXcalibur (Windows 2000)TSP, Agilent and Waters (also LC-Packings, Spark, Gilson en CTC)high resolution at Q1 and Q3, accurate mass optionThermo FinniganMAT95 XP LC-MSMagnetic sector (BE)At maximum acceleration: 3500 DaESI, APCI, Nano-ESIXcalibur (Windows 2000)TSP, Agilent and Waters (also LC-Packings, Spark, Gilson en CTC)Options:GC-MS, DIP and DCI probe, FAB, FD/FI, EI/CI, Ion-Trap for MS/MS (LCQ Deca XP)Thermo FinniganMAT900 XL LC-MSMagnetic sector (EB)Ar maximum acceleration: 5000 DaESI, APCI, Nano-ESIXcalibur (Windows 2000)TSP, Agilent and Waters (also LC-Packings, Spark, Gilson en CTC)Options:GC-MS, DIP and DCI probe, FAB, FD/FI, EI/CI, Ion-Trap for MS/MS (LCQ Deca XP) and Patric detectorThermo FinniganFTMS ( FT-IC