药剂学英文术语.doc

生物药剂学英文汉译英要求Biopharmaceutics生物药剂学Absorption吸收Distribution分布Metabolism代谢Excretion排泄Transport转运Disposition处置Elimination消除Transcellular pathway细胞通道转运Paracellular pathway细胞旁路通道转运Passive transport被动转运Pore transport膜孔转运Carrier-mediated transport载体媒介转运Facilitated diffusion易化扩散、促进扩散Active transport主动转运Membrane mobile transport膜动转运 Pinocytosis胞饮作用Phagocytosis吞噬作用First pass effect首过效应pH-partition hypothesis pH-分配假说Dissolution溶出Parenteral drug delivery注射给药Oral cavity mucosa drug delivery口腔粘膜给药Transdermal drug delivery皮肤给药Nasal mucosa drug delivery鼻粘膜给药Pulmonary drug delivery肺部给药Rectal drug delivery直肠给药Ophthalmic drug delivery眼部给药Distribution分布Accumulation蓄积Apparent volume of distribution表观分布容积Metabolize, metabolism代谢Biotransformation生物转化Inhibition酶抑制作用Inhibitor酶抑制剂Induction酶诱导作用Inducer酶诱导剂英译汉要求Membrane transport膜转运Fluid mosaic model生物膜液态镶嵌模型Extrinsic proteins外在蛋白Intrinsic proteins内在蛋白Fluidity流动性Asymmetry不对称性Semipermeability半透性P-glycoprotein P糖蛋白Vesicle小泡Endocytosis入胞作用Exocytosis出胞作用Kerckring环状褶壁Villi绒毛Epithelium cell上皮细胞Microvilli微绒毛Apical membrane顶侧膜Brush border membrane刷状缘膜Basal membrane基底膜Lateral membrane侧细胞膜Tight junction紧密结合Solvent drag effect溶媒牵引效应Gastric emptying rate胃空速率Liver first pass effect肝首过效应Lymphatic circulation淋巴循环Ionization解离度Lipophilicity脂溶性Dissolution rate溶出速率Molecular weight分子量Oil-water partition coefficient油水分配系数Sink condition漏槽条件Critical particle size, CPS临界粒径Polymorphism多晶型Absorption number, An吸收指数Dose number, Do剂量指数Dissolution number, Dn溶出指数Permeation enhancer透过促进剂或Absorption enhancer吸收促进剂Solid dispersion tech固体分散技术Dispersible tablet分散片Effervescent tablet泡腾片Sustained-release preparation缓释制剂Controlled-release preparation控释制剂Stability稳定性Day/night rhythm昼夜节律Site-specific drug delivery system定位释药系统Oral delayed-release preparation口服迟释制剂Stomach-specific preparation口服胃滞留制剂Floating漂浮型Swelling膨胀型Sticking粘附型Intestine-specific preparation小肠迟释制剂Oral colon-specific drug delivery system, OCDDS口服结肠定位给药系统In vitro experimental model离体实验模型Tissue flux chambers组织流动室法Mucosa粘膜Secosa浆膜Everted gut sac外翻肠囊法Everted rings外翻环法In situ experimental model原位实验模型Intestine perfusion method肠道灌流法In vivo experimental model体内法Intravenous injection静脉注射Intramuscular injection肌内注射Hypodermic injection皮下注射Intradermic injection皮内注射Solid particle precipitation固体粒子析出Masticatory mucosa咀嚼粘膜Lining mucosa内衬粘膜Specialized mucosa特性粘膜Buccal mucosa颊粘膜Sublingual mucosa舌下粘膜Transdermal drug delivery system, TDDS/Transdermal therapeutic system经皮给药系统Physiologic factors生理因素Iontophoresis离子导入技术Cilia movement纤毛运动Surfactant表面活性剂Eyelid眼睑Eye adjunct眼附属器Cornea角膜Drug-protein binding药物-蛋白结合Albumin白蛋白Alpha acid glycoprotein, AAG 1-酸性糖蛋白Lipoprotein脂蛋白Binding constant结合常数Blood-brain barrier血-脑脊液屏障Inter-membrane transfer膜间转运Contact release接触释放Adsorption吸附Fusion融合Endocytosis内吞Pinocytosis胞饮Long-circulating DDS长循环微粒给药系统Target drug delivery system靶向给药系统Intracellular target of biomacromolecule生物技术药物的细胞内靶向Liver microsome enzymes微粒体药物代谢酶系Live microsome mixed function monooxygenase肝微粒体混合功能氧化酶或单加氧酶Glucuronyl transferase葡萄糖醛酸转移酶The first phase reaction第一相反应Combination reaction结合反应Optical isomerism光学异构Cortex皮质Medulla髓质Nephron肾单位Glomerular filtration肾小球滤过Active tubular secretion肾小管分泌Tubular reabsorption肾小管重吸收Inulin菊粉Biliary excretion胆汁排泄Renal clearance肾清除率Enterohepatic cycle肠肝循环Compartment model隔室模型Single compartment mode一室模型Two compartment model二室模型Multicompartment model多室模型First order processes一级速度过程Zero order processes零级速度过程Nonlinear processes非线性速度过程Pharmacokinetics, PK药物动力学Population pharmacokinetics, PPK群体药物动力学Clinical pharmacokinetics临床药物动力学Therapeutic drug monitoring, TDM治疗药物监测Chronopharmacokinetics时辰药物动力学Physiological pharmacokinetic model生理药物动力学模型Biological half life生物半衰期Sigma-minus method亏量法，又称总和-减量法Steady-state drug concentration稳态血药浓度Loading dose负荷剂量Lag time滞后时间Extravascular delivery血管外给药Plateau level坪浓度Fluctuation percentage, FI波动百分数Degree of fluctuation, DF波动度Product inhibition产物抑制Plasma drug concentration change percentage血药浓度变化率Capacity-limited process容量限制过程Design of dosage regimen临床给药方案设计Individualization of drug dosage regimes给药方案个体化B