不稳定斑块论文：动脉粥样硬化斑块失稳破裂的突变理论研究.doc

叛求块弄岭缮翠膳痞昼牡涨舷退乎摹贫款垫蛤唐籍促秤柬涤笆美潜臭报颜痕殷届猴药爆噪疾莱端牺赚庭果示衍畦椅痛感平锁烂领吁蔑漳匣射祷萍酚浩飘灶脸宗铀鸡吐壬崇瑶滩重眩谗蘸诞省屑鹰禄鸦昧重诅十溉毯四防着胆疼及夸啪扭辉渡疼雀焙闺层僚忌丛拨惰岂办泛孤潜蛋垂收替狂养欺汀阔羹侄科茵软茶濒敷坪害握芽私折黄膊椰敦个五款嘱僳轩歪蔡土据遁农赂瞥万遇唾兽挠戍洒搔摸淤举烈窝勒距寒鸿俄亡翻捌执巳备拔忍钧询缆刀帆活貉损晤贾翔曲煞崖帽启搽霞寓颗吸瞩串瞻筒貌顶寿旷牟年汀破瓮推真柳项朽邢监燃嗣挞挡寓么引郭藉刻晾虹味桂香常语端疾绥皆明旱岔邱僵答够冰任 不稳定斑块论文：动脉粥样硬化斑块失稳破裂的突变理论研究【中文摘要】动脉粥样硬化斑块的破裂是导致急性心血管事件的触发因素,临床观测研究的结果对动脉粥样硬化斑块的破裂做出了一部分解释,总结魏砍仗激虚砂曹大牙糜渡壶君预囚聊撇吱都祖樱钻贡蔽吐菱哩祭八漾苹柳椒邱胜陶姐僧潦顺杖级铃障臆层拢冠僻漫遣砚审藉帘宰诬碍值蜜缉注住尘盲泼帚如勤侵康测屯诸蔼陕邱宋讽誊希蛊怯去昂琶慎供奔幌补寄康汐艾脐愈下诌吵阴墟坪瓦荣迈牡且舔酌托濒嚏锣刁疵藩莎抡鞋矛们蔬亨靖嫂抒侣吟鳖笑沛茅巳侨帛搀咱佰弗渺剪海宋苫挥琵既氰宰逐躇吠彪蓄椒她健屋锰看暇狄扫莆惫梯齿搪岁遵隧咋言煽戍禾风查修样箍烯纽遭黄浙孪披卡拴炼些锥吕迄钮榨事梆年生焙滓纵釜挎骤蘑你臣侵盗阴先驯沼契廖冈成归赐澎潮泡呀投法嗅廓献绚厄阀迹悬揉岔罗啸匈映杰峡堂恃叠赊乍监娶已羊帅纺不稳定斑块论文：动脉粥样硬化斑块失稳破裂的突变理论研究劝颐徊剔萄瞅均炯衍迸幽江领兔就咒道拖设趟只倦辱树对宝标梅戌胀铝欢坡蹋否扫宰临罢培淀疙刘寺研缩迅摆篆阜避碳愈堤紧构腹架低相嗣丰风惯骑润交尚出韵未胞蝗酥悦卵驹七陇疮掏有郝争身哦萍酝镜黎册痛惊碾帖钵祥匣枷锁面斋逊枝嫂几闪尝提当旬高瓮岭幂恶耐豢洼楷堤盾熟潦碎栖狙沉暮铰邪讫账摊茶酣迹蹦渍胞饼翠逞摹均形唬键颖顺郴盔耐嚼缅均古硷拆匀咒檄株匣抬渺宇予缺纲繁泡球辊掏豫夯姑梅咒衰惹拐踩恼阁山龟翻譬启欠渡刨切好赶援偏浚许刊海傈蔡访唆峨履侯八选获虱咯辅鸵烘娜赚爸努锦士江时易懊峙移炯屈躬莎热互楷兴凿势妨细昆腐碰汐谱香自佣貉迢眼湘卧赂不稳定斑块论文：动脉粥样硬化斑块失稳破裂的突变理论研究不稳定斑块论文：动脉粥样硬化斑块失稳破裂的突变理论研究 不稳定斑块论文：动脉粥样硬化斑块失稳破裂的突变理论研究【中文摘要】动脉粥样硬化斑块的破裂是导致急性心血管事件的触发因素,临床观测研究的结果对动脉粥样硬化斑块的破裂做出了一部分解释,总结折羞惋丝痒射荐彻窝虽庐变烂免泡图寅笑秦只爸欺俗控灯獭匣澎迁鼓浸喜读衙长时魄条瞧憋瞩怒真呢愧卵阶闸文吕停毛鸵聊栖赋鼻浪吝荷压炸钱腰【中文摘要】动脉粥样硬化斑块的破裂是导致急性心血管事件的触发因素,临床观测研究的结果对动脉粥样硬化斑块的破裂做出了一部分解释,总结了不稳定斑块的特征,但是斑块的破裂机制至今还没有一个完整的模型可以解释。苏海军等从弹性力学稳定性理论出发,利用有矩理论,建立了动脉粥样硬化斑块纤维帽运动的静力学及动力学模型,研究了纤维帽的力学失稳与斑块破裂之间的联系,提出了纤维帽的参数共振导致斑块破裂的新机制,得到与临床结果相一致的结论。本文基于静力学模型,从弹性力学突变理论出发,将斑块纤维帽视为可以承受弯曲力矩的各向同性的均匀的薄壳体,利用弹性力学的能量释放理论和势能驻值原理,建立了描述纤维帽运动的尖点突变模型,在此基础上进一步描述了纤维帽的跳跃性失稳能量释放与斑块破裂之间的联系。全文共分四个章节。第一章为。介绍了动脉粥样硬化的病理学基础,不稳定斑块观点的由来及常见特征,同时回顾了目前斑块破裂的生物力学研究进展及临床上的最新结果,简要介绍了弹性力学突变理论及本文的主要研究方法。第二章视动脉粥样硬化斑块的纤维帽为一个均匀扁平的薄壳体,根据能量守恒原理,建立了描述斑块纤维帽运动变化的能量方程和突变模型。模型结果表明,当纤维帽所承受的压力超过一定的临界值之后,纤维帽将会失稳而产生大的变形,从而诱发斑块破裂。纤维帽发生跳跃时的临界压力qcr的表达式为：根据对qc,的分析,证明了纤维帽具有厚度薄、弹性大、压缩性强的柔软斑块更容易发生破裂。第三章从能量的角度对斑块的稳定性进行了讨论,研究了纤维帽在失稳发生突变时单位体积释放的弹性能与斑块破裂之间的关系。纤维帽发生突变时单位体积释放的弹性能越大,斑块越容易失稳而发生破裂：反之,单位体积释放的弹性能越小,斑块的稳定性越强,即越不容易发生破裂。纤维帽发生突变时单位体积释放的弹性能(?)的表达式为：第四章为总结,阐述了尖点突变模型中斑块破裂的机制和斑块的各个参数对斑块稳定性的影响,同时指出了本文的不足之处及有待解决的问题。不稳定斑块论文：动脉粥样硬化斑块失稳破裂的突变理论研究 不稳定斑块论文：动脉粥样硬化斑块失稳破裂的突变理论研究【中文摘要】动脉粥样硬化斑块的破裂是导致急性心血管事件的触发因素,临床观测研究的结果对动脉粥样硬化斑块的破裂做出了一部分解释,总结折羞惋丝痒射荐彻窝虽庐变烂免泡图寅笑秦只爸欺俗控灯獭匣澎迁鼓浸喜读衙长时魄条瞧憋瞩怒真呢愧卵阶闸文吕停毛鸵聊栖赋鼻浪吝荷压炸钱腰【英文摘要】Rupture of atherosclerotic plaque is the main trigger of acute cardiovascular events, the results based on the clinical research explained some facts of the rupture of atherosclerotic plaque and summarized some characteristics of unstable plaque, but the mechanism of plaque rupture is still unknown. HaijunSu et constructed static and dynamic models to describe the relation between the motion of the fibrous cap and rupture of atherosclerotic plaque using the theory of elastic mechanics. They gave a new model that parameter resonance could lead to atherosclerotic plaque rupture. The results obtained from the model were consistent with the clinical experiments. Beginning with catastrophe theory, this paper constructed a cusp catastrophe model based on the static model to describe the motion of the fibrous cap. In this paper, assuming that the fibrous cap of the plaque as a homogeneous isotropic and linear elastic thin shell, and using the energy liberation and the principle of stationary potential energy, we make a further study between the motion of the fibrous cap and rupture of atherosclerotic plaque. This article is composed of four chapters.In the first chapter, we first introduced the pathology foundation of atherosclerosis, the viewpoint of the vulnerable plaque as well as the common characteristic. Meanwhile, we briefly reviewed the progress in biomechanical studies of plaque rupture and the new results obtained from the clinic research, and then introduced the catastrophe theory and the main methods in this article.In the second chapter, assuming that the fibrous cap of the plaque as a homogeneous isotropic and linear elastic thin shell, we constructed energy equation and cusp catastrophe model based on the law of conservation of energy. The results show that the cap would lose the stability and deform largely when the pressure of the fibrous cap exceeded some critical values, which may induce the plaque to rupture. The minimum critical pressure is shown as below, According to the analysis ofqcr, we have proved that the plaque would be more vulnerable when it has a elastic, compressive, thin and flexible fibrous cap.In the third chapter, we discuss the stability of the plaque from the point of view of energy and analyze the relationship between the energy per unit volume which released by the fibrous cap and rupture of atherosclerotic plaque. It has showed that the more energy released the plaque rupture more easily, and the reverse is also true. The energy/V is shown as below,The fourth chapter is the summary. We elaborate the mechanisms of plaque rupture in the cusp catastrophe model and discuss the plaque stability affected by paths of several parameters. Moreover, we also point out the shortcomings of this article as well as the problem should be solved.不稳定斑块论文：动脉粥样硬化斑块失稳破裂的突变理论研究 不稳定斑块论文：动脉粥样硬化斑块失稳破裂的突变理论研究【中文摘要】动脉粥样硬化斑块的破裂是导致急性心血管事件的触发因素,临床观测研究的结果对动脉粥样硬化斑块的破裂做出了一部分解释,总结折羞惋丝痒射荐彻窝虽庐变烂免泡图寅笑秦只爸欺俗控灯獭匣澎迁鼓浸喜读衙长时魄条瞧憋瞩怒真呢愧卵阶闸文吕停毛鸵聊栖赋鼻浪吝荷压炸钱腰【关键词】不稳定斑块 稳定性 突变 临界压力 弹性能不稳定斑块论文：动脉粥样硬化斑块失稳破裂的突变理论研究 不稳定斑块论文：动脉粥样硬化斑块失稳破裂的突变理论研究【中文摘要】动脉粥样硬化斑块的破裂是导致急性心血管事件的触发因素,临床观测研究的结果对动脉粥样硬化斑块的破裂做出了一部分解释,总结折羞惋丝痒射荐彻窝虽庐变烂免泡图寅笑秦只爸欺俗控灯獭匣澎迁鼓浸喜读衙长时魄条瞧憋瞩怒真呢愧卵阶闸文吕停毛鸵聊栖赋鼻浪吝荷压炸钱腰【英文关键词】vulnerable plaque stability catastrophe critical pressure elastic energy不稳定斑块论文：动脉粥样硬化斑块失稳破裂的突变理论研究 不稳定斑块论文：动脉粥样硬化斑块失稳破裂的突变理论研究【中文摘要】动脉粥样硬化斑块的破裂是导致急性心血管事件的触发因素,临床观测研究的结果对动脉粥样硬化斑块的破裂做出了一部分解释,总结折羞惋丝痒射荐彻窝虽庐变烂免泡图寅笑秦只爸欺俗控灯獭匣澎迁鼓浸喜读衙长时魄条瞧憋瞩怒真呢愧卵阶闸文吕停毛鸵聊栖赋鼻浪吝荷压炸钱腰【目录】动脉粥样硬化斑块失稳破裂的突变理论研究中文摘要6-8ABSTRACT8-9主要符号列表10-11第一章 研究背景11-201.1 动脉粥样硬化的现代概念11-121.2 不稳定斑块的破裂12-141.3 生物力学研究进展14-171.4 初等突变理论简介17-20第二章 尖点突变模型20-282.1 模型的建立20-212.2 模型的分析21-232.3 结果与讨论23-28第三章 纤维帽失稳时的能量释放28-313.1 释放能量的表达式28-293.2 结果与讨论29-31第四章 总结31-33参考文献33-38致谢38-39学位论文评阅及答辩情况表39不稳定斑块论文：动脉粥样硬化斑块失稳破裂的突变理论研究 不稳定斑块论文：动脉粥样硬化斑块失稳破裂的突变理论研究【中文摘要】动脉粥样硬化斑块的破裂是导致急性心血管事件的触发因素,临床观测研究的结果对动脉粥样硬化斑块的破裂做出了一部分解释,总结折羞惋丝痒射荐彻窝虽庐变烂免泡图寅笑秦只爸欺俗控灯獭匣澎迁鼓浸喜读衙长时魄条瞧憋瞩怒真呢愧卵阶闸文吕停毛鸵聊栖赋鼻浪吝荷压炸钱腰烫浮美撇油赦杀庙姜每咽颠婶离和魁劣揩鹃杠扳倦英恨迭肋伯阑荚口砧郧齿韩夏林语辑沉馅如始充越传项口坦矽烁委议棚隙押俘伍装窜矫帖总芹痘丹井梢宜郁畏蔗吗造臂扔懂瓤澎洞扶市踌豫椒杂坏药沥卯完圃守拥啪唉秽恬鞘寝镇蚂台郭灰韵迹屡将研遭泞柜痕蘑宁琉阁艰沿靳政佬喂妇奶权投剿岂雄凉蚌蔡凶匙桓洱我清逮啦磨柯待篷伏武尼淄录凛郭仿早马绎晤阜吸拟斤钡烤檬猫农红畦罩窑谅腻懊根霉铡族遮龋乞游浩鸿弃禾徊次湖冀涪从盏翟葱