嗅觉嗅出病理细胞.pdf

嗅觉嗅出病理细胞嗅觉嗅出病理细胞 Sam Zhou 2012 3 20 The mammalian olfactory system does more The mammalian olfactory system does more than just detect food odors and pheromones Th difl lf lfThe discovery of a novel class of olfactory receptor provides evidence that mammals can also sniff out cell damage and disease Mice use olfactory cues to avoid potential mates that 各种现象例证各种现象例证 yp are infected with parasites Nematode worms develop aversions to odors givenNematode worms develop aversions to odors given off by harmful bacteria thereby avoiding toxic food The identification of a previously unrecognized type of chemosensory neuron in the rodent nose that responds yp to stimuli associated with cell damage disease and inflammation Identify pathogens or assess the health status of potential partners Formyl peptide evoked Ca2 signals 犁鼻器映射到辅嗅球 accessory bulb Formyl peptide evoked Casignals in the intact vomeronasal epithelium Formyl peptide receptor在免疫细胞中被发现 用于调节细胞的损伤 疾病和炎症 运用细胞组织工程在细胞膜表面表达FPR 甲酰肽受体 蛋白 通运用细胞组织工程在细胞膜表面表达 甲酰肽受体 蛋白 通 过钙成像分别对物质CRAMP uPAR LXA4 fMLF 的响应 犁鼻器感觉神经元有甲酰肽受体 甲酰肽 受体也存在于粒细胞 单核细胞 巨噬细 胞中 与免疫相关 甲酰肽受体主要包括 甲酰肽受体主要包括 艾滋病毒衍生肽 HIV derived peptide 阳离子抗菌肽相关肽th lil t dtiibil阳离子抗菌肽相关肽 cathelin ralated antimicrobioal peptide CRAMP 尿激酶型纤溶酶原激活剂受体 Urokinase type plasminogen尿激酶型纤溶酶原激活剂受体 Urokinase type plasminogen activator re