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1微小剂量阿司匹林对正常小鼠及高尿酸血症模型小鼠血尿酸的影响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,PEKINGUNIVERSITY,BEIJING10083,CHINAABSTRACTOBJECTIVETHEAIMOFSTUDYWASTOEVALUATETHEEFFECTSOFMINIDOSAGESOFASPIRINONBLOODURICACID,CREATININEANDUREANITROGENINNORMALMICEHYPERURICEMIAMODELMICEMETHODS120MICEWERERANDOMIZEDINTO8GROUPS,CONSISTSOFNORMALCONTROLLEDGROUP,HYPERURICEMIACONTROLLEDGROUP,NORMALEXPERIMENTALGROUP3GROUPSANDHYPERURICEMIAEXPERIMENTALGROUP3GROUPSNORMALANDHYPERURICEMIACONTROLLEDGROUPSWEREADMINISTRATED05CMCNA,NORMALANDHYPERURICMIAEXPERIMENTALGROUPSWEREADMINISTEREDASPIRINASFOLLOW125MG/KG/D,25MG/KG/D,50MG/KG/DTHEDOSAGEOFCMCNAANDASPIRINKEEPAWEEKTHENNORMALEXPERIMENTALGROUPSBLOODWASCOLLECTED1HOURLATERAFTERTHELASTADMINISTRATIONFORDETERMINATIONURICACID,CREATININEANDUREANITROGENANDNORMALCONTROLLEDGROUPRECEIVEDANINTRAPERITONEALINJECTIONOF05CMCNAIMMEDIATELYAFTERTHELASTADMINISTRATION,ATTHESAMETIMEHYPERURICEMIACONTROLGROUPANDTHREEEXPERIMENTALGROUPSTREATEDWITHINTRAPERITONEALINJECTIONOFURICSOLUTIONONEHOURLATER,THEBLOODWASCOLLECTEDFORDETERMINATIONURICACID,CREATININEANDUREANITROGENRESULTMINIDOSAGEHASNOAPPARENTEFFECTONCREATININEANDUREANITROGEN,BUTCANINCREASEREMARKABLYTHELEVELOFBLOODURICACIDATTHELOWESTDOSAGEOF125MG/KG/D,THELEVELOFBLOODURICACIDRAISEDTOTHEPEAKTHEEFFECTONBLOODURICACIDWEREGRADUALLYREDUCEDTOBASELINEWITHINCREASINGDOSAGEOFASPIRIN,ANDTHETTESTSHOWEDNOSTATISTICALLYSIGNIFICANTDIFFERENCEBETWEENASPIRINGROUPANDCONTROLLEDGROUPCONCLUSIONMINIDOSEASPIRINCANCAUSESIGNIFICANTINCREASEINBLOODURICACIDLEVELINHYPERURICEMIAMODELMICE,ANDTHISEFFECTWEREDECREASEDWITHINCREASINGDOSAGEOFASPIRINPATIENTS,ESPECIALLYPATIENTWITHGOUTANDHYPERURICEMIANEEDTOMONITORTHELEVELOFBLOODURICACIDREUGULARKEYWORDSASPIRINA139HYPERURICEMIAMODELA139BLOODURICACIDA139CREATININEA139UREANITROGENA142A143A144A145A146A147A148A149A150A151A152A153A154A155A156A146A157A158A154A159A160A161A142A143A144A145A162A163A164A165A166A167A168A169A170A171A172A173A174A175A154A176A177A178A179A180A181A182A183A184A185A186A187A188A189A190A191A192A193A194A195A196A197A198A199A200A201A202A203A204A205A206A207A208A209A194A195A210A211A212A178A179A180A181A213A214A215A2162A178A179A180A181A217A218A219A220A221A222A223A224A225A226A212A199A227A228A229A206A209A230A231A232A231A233A210A230A231A234A235A233A236A237A196A238A239A240A241A242A243A199A178A179A180A181A209A244A245A246A247A248A249A235A250A251A252A253A222A223A254A236A218A219A255A186A196A226A212A199A212A0A245A246A248A230A159A160A250A251A252A253A85A1A2A218A219A215A3A213A4A215A213A5A215A216A178A179A180A181A12A6A7A8A0A9A226A212A196A245A246A183A10A11A222A232A159A235A160A232A197A250A251A252A199A123A183A245A246A13A14A15A16A11A17A0A245A246A248A49A229A18A232A197A250A251A252A253A216A19A20A21A22A23A24A187A25A212A196A192A182A17A0A245A246A178A179A180A181A199A101A26A212A177A27A28A29A127A196A30A31A32A33A34A35A240A36A37A38A39A29A127A30A31A32A33A34A229A196A183A40A41A42A40A43A44A216A212A223A45A17A0A245A246A178A179A180A181A182A46A47A217A218A219A220A221A48A189A123A184A224A225A50A51A196A52A53A54A55A56A57A216A58A59A60A61A62A229A206A213A214A215A20A63A116A240A241A64A17A0A245A246A178A179A180A181A217A65A233A206A218A219A220A221A196A50A51A199A73A66A67A68A199A222A232A197A250A251A252A196A69A197A245A246A70A211A8A218A219A71A72A243A67A74A75A199A212A76A69A197A245A246A77A78A79A230A232A229A197A250A251A252A210A235A160A232A197A250A251A252A247A199A8A218A219A80A81A85A107A82A83A84A199A86A87A88A89A71A72A216A13A224A90A190A177A65A91A92A93A47A199A65A233A206A238A153A94A247A29A223A203A184A95A96A199A101A26A97A98A29A127A94A247A29A223A99A31A199A41A182A27A28A29A127A94A247A100A22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