控制昼夜节律的分子机制ppt课件

控制昼夜节律的分子机制,1,First,twoquestions.,Whendoyougetup?Whendoyougotobed?,控制昼夜节律的分子机制,2,Thebiologicalclockiswarningyou,Themolecularmechanismofcontrollingcircadianrhythm控制昼夜节律的分子机制,Reporter：ZhangQing2018.06.06,控制昼夜节律的分子机制,3,Thesunsetbuttherest.（日落而息）,Thesunrisemakes.(日出而作),Aphenomenonofthecircadianrhythm/thebiologicalclock,控制昼夜节律的分子机制,4,HOWDOESITWORKINGENE?,控制昼夜节律的分子机制,5,Thefruitfly:sleepsduringthedayhowlsduringthenight,WHY?,Themutation(缺失)ofaperiodgeneinthebody,周期基因,控制昼夜节律的分子机制,6,HowtoRealizeRegulationofCircadianRhythmprecisly?如何实现昼夜节律的精确调控?,WhatIsthePeriodGene?,控制昼夜节律的分子机制,7,TheperiodgeneencodesaproteincalledPER.ThetimelessgeneencodesaproteincalledTIM.Thedouble-timegeneencodesaproteincalledDBT.,控制昼夜节律的分子机制,8,ThePERproteinwillbetransferredfromthecytoplasm(细胞质)tothenucleuswiththehelpofTIMproteinatnight.ThePERproteinwilldegrade（降解）duringtheday.Theprocessofaccumulationanddegradationisabout24hours,whichcorrespondstopeoplesdayandnight.DBTistoslowdowntheaccumulation（积累）ofPERprotein,whichallowspreciseregulationofcircadianrhythms.,控制昼夜节律的分子机制,9,Openthelockrequirestwokeys,onecalledthePERproteinandtheothercalledaTIM.Thefrequency(频率)ofopeningthedooriscontrolledbytheDBTprotein.,Theprocessislikedasalockandakey,控制昼夜节律的分子机制,10,First,healsomeofthegeneticdiseases（遗传性疾病）.Second,cureinsomnia(失眠).Third,revealthedangerofstayinguplate.,WhatisTheUseofThisFinding?,控制昼夜节律的分子机制,11,Atlastbutnotatleast,wemustletthebodyrestattherighttime.Payattentiontotheb