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Basic Facts About HIV/AIDSIn western countries, women are four times more likely to contract HIV through vaginal sex with infected males than vice versa. This biological vulnerability is worsened by social and cultural factors that often undermine womens ability to avoid sex with partners who are HIV infected or to insist on condom use. In the U.S., the proportion of AIDS cases among women more than tripled from 7% in 1985 to 25% in 1999. African American and Hispanic women, who represent less than one-quarter of U.S. women, represent nearly 80% of AIDS cases reported among American women to date.Are young people at significant risk of HIV infection?Nearly half of the roughly 40,000 Americans newly infected with HIV each year are under the age of 25. Approximately two young Americans become infected with HIV every hour of every day, and about 25% of the people now living with HIV in this country became infected when they were teenagers. Statistics show that by the age of 19, at least half of females and 60% of males in this country have engaged in sexual intercourse, and two-thirds of STIS affect people under age 25. Many young people also use drugs and alcohol, which can increase the likelihood that they will engage in high-risk sexual behavior.Are there treatments for HIV/AIDS?For many years, there were no effective treatments for AIDS. Today, people in the United States and other developed countries can use a number of drugs to treat HIV infection and AIDS. Some of these are designed to treat the opportunistic infections and illnesses that affect people with HIV/AIDS. In addition, several types of drugs seek to prevent HIV from reproducing and destroying the bodys immune system: Reverse transcriptase inhibitors attack an HIV enzyme called reverse transcriptase. They include abacavir, delavirdine, didanosine (ddI), efavirenz, emtricitabine( FTC), lamivudine (3TC), nevirapine, stavudine (d4T), tenofovir, zalcitabine (ddC), and zidovudine (AZT); Protease inhibitors attack the HIV enzyme protease and include amprenavir, atazanavir, fosamprevavir, indinavir, lopinavir, nelfinavir, ritonavir, and saquinavir. Fusion inhibitors stop virus from entering cells. To date, there is only one fusion inhibitor approved by the Food and Drug Administration, enfuvirtide.Many HIV patients take these drugs in combination in a regimen known as highly active antiretroviral therapy (HAART). When taken as directed, these drugs can reduce the level of HIV in the bloodstream to very low levels and enable the bodys CD4 immune cells to rebound to normal levels.Researchers are continuing to develop new drugs that act at critical steps in the life cycle of the virus. Efforts are also underway to identify new targets for anti-HIV medications and to discover ways of restoring the ability of damaged immune systems to defend against HIV and the many illnesses that affect people with HIV. Ultimately, advances in rebuilding the immune system in HIV patients will benefit people with a number of serious illnesses, including cancer, Alzheimers disease, multiple sclerosis, and immune deficiencies associated with aging and premature birth.Is there a cure for AIDS?There is still no cure for AIDS. And while new drugs are helping many people with HIV/AIDS live longer, healthier lives, there are many problems associated with them: Anti-HIV drugs are highly toxic and can cause serious side effects, including heart damage, kidney failure, and osteoporosis. Many (perhaps even most) patients cannot tolerate long-term treatment with HAART. HIV mutates quickly. In as many as 50% of people on HAART, HIV mutates into new viral strains that have become highly resistant to current drugs, and as many as 10% of newly infected Americans are acquiring drug-resistant strains of the virus. Because treatment regimens are unpleasant and complex, many patients miss doses of their medication. Failure to take anti-HIV drugs on schedule and in the prescribed dosage encourages the development of new viral strains that are resistant to current HIV drugs. Even among those who do respond well to treatment, HAART does not eradicate HIV. The virus continues to replicate at low levels and often remains hidden in reservoirs in the body, such as the lymph nodes and brain.In the U.S., the number of AIDS-related deaths has decreased dramatically because of widely available potent treatment. But more than 95% of all people with HIV/AIDS live in the developing world, where access to treatment may be limited at best.Is there a vaccine to prevent HIV infection?Despite continued intensive research, experts believe it will be at least a decade before we have a safe, effective, and affordable AIDS vaccine. And even after a vaccine is developed, it will take many years before the millions of people at risk of HIV infection worldwide can be immunized. Until then, other HIV prevention methods, such as using condoms and avoiding needle-sharing, will remain essential.Can you tell whether someone else has HIV or AIDS?You cannot tell by looking at someone whether he or she is infected with HIV or has AIDS. An infected person can appear completely healthy. But anyone infected with HIV can infect other people, even if no symptoms are present.How do I know if Im infected?Immediately after infection, some people may develop mild, temporary flu-like symptoms or persistently swollen glands. Even if you look and feel healthy, you may be infected. The only way to know your HIV status for sure is to be tested for HIV antibodies, that is, proteins the body produces in an effort to fight off infection. This usually requires a blood sample. If your blood has HIV antibodies, that means you are infected.Should I get tested?If you think you might have been exposed to HIV, you should get tested as soon as possible. Heres why: Even in the early stages of infection, you can take concrete steps to protect your long-term health. Many physicians still recommend a hit early and hit hard approach to anti-HIV therapy. But even if you dont begin taking medications right away, regular check-ups with a doctor who has experience with HIV/AIDS will enable you (and your family members or loved ones) to make the best decisions about how and when to begin treatment, without waiting until you get sick. Taking an active approach to managing HIV may give you many more years of healthy life than you would otherwise have. If you are HIV positive, you will be able to take the precautions necessary to protect others from becoming infected. If you are HIV positive and pregnant, you can take medications and other precautions to significantly reduce the risk of infecting your infant, including refraining from breast-feeding.How can I get tested?Most people are tested by private physicians, at local health department facilities, or in hospitals. In addition, many states offer anonymous HIV testing. It is important to seek testing at a place that also provides counseling about HIV and AIDS. Counselors can answer questions about high-risk behavior and suggest ways you can protect yourself and others in the future. They can also help you understand the meaning of the test results and refer you to local AIDS-related resources.Though less readily available, there is also a viral load test that can reveal the presence of HIV in the blood within three to five days of initial exposure, as well as highly accurate saliva tests that are nearly equivalent to blood tests in determining HIV antibody status. You can also purchase a kit that allows you to collect your own blood sample, send it to a lab for testing, and receive the results anonymously. Only the Home Access brand kit is approved by the Food and Drug Administration. It can be found at most drug stores.Keep in mind that while most blood tests are able to detect HIV infection within four weeks of initial exposure, it can sometimes take as long as three to six months for antibodies to reach detectable levels. The CDC currently recommend testing six months after the last possible exposure to HIV.The CDCs National AIDS Hotline can answer questions about HIV testing and refer you to testing sites in your area. Operators are available toll-free, 24 hours a day, seven days a week, at:1-800-342-2437 (English)1-800-344-7432 (Spanish)1-800-243-7889 (TTY/deaf access)Where can I get more inf
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