SCI论文写作Session 11 Editing of 3 Manuscripts 10-9-17

Session11EditingofThreeManuscriptsPart1,ToxicologyLetters2014;225:275-84,ScientificWriting,Editing,andPublishing,1,Original:p53/miR-34caxismediatedcellcycleisinvolvedincellmalignanttransformationinducedbybenzoapyreneConcerns:Stackedwords(x2);wordmissing.Final:Cellcyclechangesmediatedbythep53/miR-34caxisareinvolvedinthemalignanttransformationofcellsbybenzoapyrene,ScientificWriting,Editing,andPublishing,Title,Session11,2,Original:IdentificationofaberrantmicroRNA(miRNA)expressionduringchemicalcarcinogen-inducedcelltransformationwillleadtoabetterunderstandingofthesubstantialroleofmiRNAsincancerdevelopment.Concerns:Lackofprecision;unnecessarywords;useofrole.Final:CharacterizationofaberrantmicroRNA(miRNA)expressionduringcarcinogen-inducedcelltransformationwillleadtoabetterunderstandingofthefunctionofmiRNAsincancerdevelopment.,ScientificWriting,Editing,andPublishing,Abstract,Session11,3,Original:TheresultsshowedthatchronicexposuretoBaPinducedmalignanttransformationofcells.InBaPtransformed-cells,therewereincreasedlevelsofmutantp53(mt-p53),andgreaterdown-expressionofwild-typep53(wt-p53)andphosphorylatedp53(p-p53).Concerns:Toomanywords;repeatedwords;awkwardstatement,greaterdown-expression.Final:ChronicexposuretoBaPinducedmalignanttransformationofcells,inwhichtherewereincreasedlevelsofmutantp53(mt-p53)andreducedexpressionofwild-typep53(wt-p53)andphosphorylatedp53(p-p53).,ScientificWriting,Editing,andPublishing,Abstract,Session11,4,Original:Thus,wehavereportedthatp53/miR-34caxismediatedcellcycleregulationisinvolvedinthemalignanttransformationofcellsinducedbyBaP.Concerns:Toomanywords;stackedwords;unnecessaryword.Final:Thus,changesinthecellcyclemediatedbythep53/miR-34caxisareinvolvedinthemalignanttransformationofcellsinducedbyBaP.,ScientificWriting,Editing,andPublishing,Abstract,Session11,5,Original:GrowingevidencesuggeststhatmiRNAsmightfunctionasoncogenesortumorsuppressorgenes,andabnormalexpressionofmiRNAscontributestothedevelopmentofhumancancers.Concerns:Toomanywords;twoweakwords;repeatedwords.Final:miRNAscanfunctionasoncogenesortumorsuppressorgenes,andtheirabnormalexpressioncontributestothedevelopmentofhumancancers.,ScientificWriting,Editing,andPublishing,Introduction,Session11,6,Original:OthersandourpreviousstudiesalsodemonstratedthataberrantexpressionofmiRNAsmightcontributetochemicalcarcinogenesis.Concerns:Awkwardconstruction;useofpasttense;weakword.Final:OurworkandthatofothersdemonstratethataberrantexpressionofmiRNAscontributestochemicalcarcinogenesis.,ScientificWriting,Editing,andPublishing,Introduction,Session11,7,Original:BaP,isaprocarcinogenrequiringmetabolismandmetabolicactivationtoformtheultimatecarcinogen,hasbeenclassifiedasahumancarcinogen.Concerns:Impropercomma;repeatedwords(x2).Final:BaP,aprocarcinogenrequiringmetabolicactivationtoproduceitsreactiveform,hasbeenclassifiedasahumancarcinogen.,ScientificWriting,Editing,andPublishing,Introduction,Session11,8,Original:ExposuretoBaPinducesanimaltumorformationandcelltransformation.Concerns:Lackofparallelism.Final:Incellcultures,BaPinducestransformationand,inanimals,tumorformation.,ScientificWriting,Editing,andPublishing,Introduction,Session11,9,Original:AndPAHs,includingBaP,havebeenfoundtocausep53mutations,leadingtolungtumorigenesis.Concerns:Unnecessarywords;undefinedabbreviation;passivevoice;lackofitalicsforagene.Final:Polycyclicaromatichydrocarbons,includingBaP,causemutationsinthep53gene,leadingtolungtumorigenesis.,ScientificWriting,Editing,andPublishing,Introduction,Session11,10,Original:Howeverithasnotbeendetermined,if,inhumancells,p53anditsdownstreamtargetmiRNAscontributeincausingBaP-inducedmalignanttransformation.Concerns:Missingcomma;unnecessarywords;stackedwords.Final:However,ithasnotbeendetermined,if,inhumancells,p53anditsdownstreamtargetmiRNAscontributetomalignanttransformationinducedbyBaP.,ScientificWriting,Editing,andPublishing,Introduction,Session11,11,Original:Tothebestofourknowledge,aimofthisstudywastoinvestigatethechangesofBaPonp53expressionanditsdownstreamtargetmiRNAsinthemalignanttransformationcausedbyBaPwereinvestigatedwithhumanbronchialepithelial(HBE)cells.Concerns:Unnecessarywords;weakwords;stackedwords;weakending.Final:Theaimofthepresentinvestigations,performedwithhumanbronchialepithelial(HBE)cells,wastodeterminetheeffectsofBaPonexpressionofp53andonitsdownstreamtargetmiRNAsintheprocessofmalignanttransformation.,ScientificWriting,Editing,andPublishing,Introduction,Session11,12,Original:Totesttheircapacityforsoft-agargrowth,differenttreatedHBEcellswereplatedintriplicate.Concerns:Weakword;stackedwords;unnecessarywords.Final:Todeterminetheircapacityforgrowthinsoftagar,HBEcellswereplatedintriplicate.,ScientificWriting,Editing,andPublishing,MaterialsandMethods,Session11,13,Original:WehavepreviouslyreportedthatarseniteisabletoaccelerateBaP-inducedneoplastictransformationandthemigrationofHBEcells.Concerns:Unnecessarywords.Final:WepreviouslyreportedthatarseniteacceleratesBaP-inducedneoplastictransformationandthemigrationofHBEcells.,ScientificWriting,Editing,andPublishing,Results,Session11,14,Original:TodeterminewhethercellschronicallyexposedtoBaPinducedneoplastictransformation,theiranchorage-independentgrowthwasevaluated.Concerns:Danglingmodifier.Final:TodetermineifcellschronicallyexposedtoBaPweretransformed,theiranchorage-independentgrowthwasevaluated.,ScientificWriting,Editing,andPublishing,Results,Session11,15,MapshowingAntarctica,16,ScientificWriting,Editing,andPublishing,Santiago,Chile(SouthAmerica),Session11,17,Original:Incontrast,thecolonynumberofnormalHBEcellsandpassage-controlHBEcellswas4.80.8and9.61.2.Concerns:Inappropriateuseofsingular;respectivelyomitted.Final:Incontrast,thecolonynumbersofnormalHBEcellsandpassage-controlHBEcellswere4.80.8and9.61.2,respectively.,ScientificWriting,Editing,andPublishing,Results,Session11,18,Original:Thedoublingtimeofcontrolcells,30.424.32h,waslongerthanthevaluefortransformedcells,24.275.31h.Concerns:Lackofparallelism.Final:Thedoublingtimeofcontrolcells,30.44.3h,waslongerthanthatfortransformedcells,24.35.3h.,ScientificWriting,Editing,andPublishing,Results,Session11,19,Original:WithincreasedtimeofexposuretoBaP,therewereincreasedexpressionsofmutantp53(mt-p53),andmoremalignantcellsandgreaterdown-expressionofphosphorylatedp53(p-p53)andwild-typep53(wt-p53).Nosuchchanges,however,wereobservedinpassagecontrolcells.Concerns:Improperorderoflist;passivevoice.Final:WithincreasedtimeofexposuretoBaP,therewereincreasednumbersoftransformedcells,increasedexpressionofmutantp53(mt-p53),anddecreasedexpressionofphosphorylatedp53(p-p53)andwild-typep53(wt-p53).Therewerenosuchchanges,however,forpassage-controlcells.,ScientificWriting,Editing,andPublishing,Results,Session11,20,Original:Theseresultsindicatethatp53isactivatedintheearlierexposuretimeandisinhibitedinthelaterexposuretimeinHBEcellsexposedtoBaP.Concerns:Overuseofexposure;weakending.Final:Theseresultsindicatethat,inHBEcellsexposedtoBaP,p53isactivatedatshortertimesandinhibitedatlongertimes.,ScientificWriting,Editing,andPublishing,Results,Session11,21,Original:miR34clevelisincreasedintheearlierexposuretimeinHBEcellsexposedtoBaP.Concerns:Improperuseofsingular;improperuseofearlier;weakending.Final:InHBEcellsexposedtoBaP,miR34clevelsareincreasedatshorterexposuretimes.,ScientificWriting,Editing,andPublishing,Results,Session11,22,Original:ThedatasuggestedthatBaPaccelerateHBEcellsprogressedfromG1toSphaseConcerns:Toomanywords;singularsubjectwithpluralverb;improperuseofprogressed.Final:BaPacceleratedprogressionofHBEcellsfromtheG1totheSphase.,ScientificWriting,Editing,andPublishing,Results,Session11,23,Original:TheseresultsconfirmthatmiR-34cisinvolvedintheBaP-inducedincreasesofCyclinD,whichpredictsthatmiR-34cviaCyclinDmaybetakespartintheBaP-inducedtransformationofHBEcells.Concerns:Impropercapitalization;awkwardconstruction;weakword.Final:TheseresultsconfirmthatmiR-34cisinvolvedintheBaP-inducedincreasesofcyclinDandthatmiR-34c,actingviacyclinD,isinvolvedintheBaP-inducedtransformationofHBEcells.,ScientificWriting,Editing,andPublishing,Results,Session11,24,Original:BaPisknownasacompletecarcinogen,capableofinitiationandpromotion.Concerns:Unnecessarywords;wordomitted.Final:BaPisacompletecarcinogen,withthecapacitytoinitiateandpromotetumorigenesis.,ScientificWriting,Editing,andPublishing,Discussion,Session11,25,Original:AndwealsofoundthatcellproliferationabilityoftheBaP-transformedcellsshowedhigherthancontrolpassagecells.Concerns:Unnecessarywords;awkwardstatement.Final:Further,theproliferationofBaP-transformedcellswasgreaterthanthatforcontrolpassagecells.,ScientificWriting,Editing,andPublishing,Discussion,Session11,26,Original:BaPcouldinduceactivationofp53,playasignificantroleincellularprotectiontogenotoxicdamage.Concerns:Unnecessarywords;andmissing;stackedwords;useofrole;misuseofto.Final:BaPinducesactivationofp53andtherebyenhancesprotectionofcellsfromgenotoxicdamage.,ScientificWriting,Editing,andPublishing,Discussion,Session11,27,Original:TheultimatemutagenicandcarcinogenicmetaboliteisBPDEwhichcanbindtoDNAandformBPDEDNAadductsleadingtoDNAdamage,whichtakepartinthecarcinogenicityofBaP.Concerns:OveruseofBPDE;omittedcomma;omittedwords;weakwords.Final:TheultimatemutagenicandcarcinogenicmetaboliteofBaPisBPDE,whichbindstoDNAandformsadductsleadingtoDNAdamage,therebyaccountingforthecarcinogenicityofBaP.,ScientificWriting,Editing,andPublishing,Discussion,Session11,28,Original:MiR-34shavebeenreportedtobeimplicatedincellproliferationandcellcyclearrest.Concerns:Unnecessarywords.Final:miR-34sareinvolvedincellproliferationandcellcyclearrest.,ScientificWriting,Editing,andPublishing,Discussion,Session11,29,Original:Inourstudy,wealsofoundthatmiR-34ccouldregulatetheexpressionofCyclinD,resultingincellcycleprogress,whichpredictedthatmiR-34cviaCyclinDmaybetakepartintheBaPinducedtransformationofHBEcells.Concerns:Variousproblems.Final:Asdeterminedinthepresentinvestigation,miR-34cregulatedtheexpressionofcyclinD,affectingcellcycleprogressionandindicatingthatmiR-34c,viacyclinD,isinvolvedintheBaP-inducedtransformationofHBEcells.,ScientificWriting,Editing,andPublishing,Discussion,Session11,30,Original:CyclinDoverexpressioninhumantumorsisdrivenbymultiplemechanismscomprisinggenomicalterations,post-transcriptionalregulation,andposttranslationalproteinstabilization.Concerns:Toomanywords.Final:Inhumantumors,over-expressionofcyclinDisdrivenbygenomicalterations,post-transcriptionalregulation,andpost-translationalproteinstabilization.,ScientificWriting,Editing,andPublishing,Discussion,Session11,31,ScientificWriting,Editing,andPublishing,Ushuaia,Argentina,SouthAmerica,Session11,32,Original:Insummary,wehaveprovidedevidencethatchronicexposureofcellstoBaPinducescellcyclepromotionthatcontributestoBaP-inducedmalignanttransformation.Concerns:Toomanywords;overuseofinduceandBaP;impreciseword;misuseofthat.Final:Insummary,chronicexposureofcellstoBaPcausesaccelerationofthecellcycle,whichcontributestomalignanttransformation.,ScientificWriting,Editing,andPublishing,Discussion,Session11,33,Original:Fig.2.Therearethedecreasesofp53functionandmiR-34alevelsduringBaP-inducedtransformationofHBEcells.Concerns:Toomanywords;stackedwords.Final:Fig.2.Decreasesinp53functionandlevelsofmiR-34aduringBaP-inducedtransformationofHBEcells.,ScientificWriting,Editing,andPublishing,LegendsforFigures,Session11,34,Original:Fig.3.EffectsofBaPonexpressionofp53inthedifferentstagesofexposuretimeinHBEcells.Concerns:Imprecisewording;weakending.Final:Fig.3.EffectsofBaPonexpressionofp53inHBEcellsafterdifferenttimesofexposure.,ScientificWriting,Editing,andPublishing,LegendsforFigures,Session11,35,Session11CommonProblemsandSolutionsPart2,MolecularCarcinogenesis2014;53:960-9,ScientificWriting,Editing,andPublishing,36,Original:InhibitionsofEpithelialtoMesenchymalTransitionandCancerStemCellLikePropertiesAreInvolvedinmiR148aMediatedAntiMetastasisofHepatocellularCarcinomaConcerns:None,ScientificWriting,Editing,andPublishing,Title,Session11,37,Original:Theepithelialmesenchymaltransition(EMT)andacquisitionofcancerstemcell(CSC)-likepropertiesareessentialstepsinthemetastasisandpostsurgicalrecurrenceofhepatocellularcarcinomas(HCCs).Concerns:None.,ScientificWriting,Editing,andPublishing,Abstract,Session11,38,Original:Asweexpected,ourdatashowedthatmiR-148alevelswereinverselycorrelatedwithdifferentstatusofHCCtissuesinvariesofdifferentiations.Concerns:Toomanywords;misusedwords.Final:TheresultsshowedthatmiR-148alevelsinverselycorrelatedwiththedifferentiationstatusofHCCtissues.,ScientificWriting,Editing,andPublishing,Abstract,Session11,39,Original:OurresultssuggestthatmiR-148ainhibitsthemetastaticofHCCbyblockingEMTandCSCs-likeproperties,inwhich,Wntsignalpathwayisinvolved.Concerns:Useoffirstperson;weakword;adjectiveusedasanoun;awkwardstatement.Final:TheresultsshowthatmiR-148ainhibitsthemetastasisofHCCsbyblockingtheEMTandCSC-likepropertiesthrougheffectsontheWntsignalingpathway.,ScientificWriting,Editing,andPublishing,Introduction,Session11,40,Original:Hepatocellularcarcinoma(HCC)isthemostcommonlivermalignancyandamajorhealthproblemglobally.Concerns:Useifmajor;weakending.Final:Hepatocellularcarcinoma(HCC),themostcommonlivermalignancy,isaglobalhealthproblem.,ScientificWriting,Editing,andPublishing,Introduction,Session11,41,Original:AcontinuedsearchformolecularmarkerswhichpredictrecurrenceofHCCsisessential.Concerns:Misuseofwhich.Final:AcontinuedsearchformolecularmarkersthatpredictrecurrenceofHCCsisessential.,ScientificWriting,Editing,andPublishing,Introduction,Session11,42,Original:CSCshavebeenidentifiedinvarioushumancancers,includingthoseoftheliver,lung,etc.Concerns:Passivevoice;useofetc.Final:CSCsarepresentinvarioushumancancers,includingthoseoftheliverandlung.,ScientificWriting,Editing,andPublishing,Introduction,Session11,43,Original:SomemiRNAs,suchasmiR-21,miR-372andmiR-373,whichareover-expressioninavarietyofmalignanciesandareimplicatedinvariousmalignancy-relatedprocesses,includingcellproliferation,invasion,andmetastasis,mayfunctionaspotentialoncogenes.Concerns:Missingcomma;misuseofover-expressed;weakandunnecessaryword.Final:SomemiRNAs,suchasmiR-21,miR-372,andmiR-373,whichareover-expressedinavarietyofmalignanciesandareimplicatedinvariousmalignancy-relatedprocesses,includingcellproliferation,invasion,andmetastasis,mayfunctionasoncogenes.,ScientificWriting,Editing,andPublishing,Introduction,Session11,44,Original:OurpresentstudyaimstoinvestigatetheeffectsofmiR-148aontheEMTprogressionandtheCSC-likeproperties,whichareresponsibleformetastasisofHCC,incelllineandtissuesofdifferentpotentialmetastasis.Concerns:Useoffirstperson;useofpresenttense;weakwords;lackofparallelism;thelastphrasenotclear.Final:ThegoalofthepresentinvestigationwastoestablishtheeffectsofmiR-148aontheEMTprogressionandontheCSC-likeproperties,whichareresponsibleformetastasisofHCCs,inculturedcellsandintissueswithdifferingcapacitiesformetastasis.,ScientificWriting,Editing,andPublishing,Introduction,Session11,45,Original:Theexclusioncriteriaofpatientsishavingprioranticancertreatmentbeforeliverresection.Concerns:Useofpluralandpresenttense;unnecessarywords.Final:Anexclusioncriterionwashavinganticancertreatmentbeforeliverresection.,ScientificWriting,Editing,andPublishing,MaterialsandMethods,Session11,46,ScientificWriting,Editing,andPublishing,FalklandIslands(offthecoastofArgentina),Session11,47,Original:Briefly,1106cellswereseededinto10cm(diameter)dishesfor72hperpassage.Concerns:Unnecessaryword;hyphenomitted.Final:Cells(1106)wereseededintodishes(10-cmdiameter)for72hperpassage.,ScientificWriting,Editing,andPublishing,MaterialsandMethods,Session11,48,Original:Allprocedureswerecarriedoutaccordingtomanufacturersprotocol.Concerns:Jargon;theomitted.Final:Allprocedureswereaccomplishedaccordingtothemanufacturersprotocol.,ScientificWriting,Editing,andPublishing,MaterialsandMethods,Session11,49,Original:MiR-148amimicwasco-transfectedwiththereporterconstructsrespectively,byusingLipofectamine2000reagent.Concerns:Theomitted;misuseofrespectively;weakending.Final:ByuseofLipofectamine2000reagent,themiR-148amimicwasco-transfectedwiththereporterconstructs.,ScientificWriting,Editing,andPublishing,MaterialsandMethods,Session11,50,Original:WeusedGAPDH(Sigma,St.Louis,MO)tocorrectfordifferencesinloadingoftheproteinsfromthecontrolandexperimentalgroups.Concerns:Useoffirstpersonandactivevoice.Final:GAPDH(Sigma,St.Louis,MO)wasusedtocorrectfordifferencesinloadingoftheproteinsfromthecontrolandexperimentalgroups.,ScientificWriting,Editing,andPublishing,MaterialsandMethods,Session11,51,Original:Byemployingahighlysensitive,high-throughputandspecificmiRNAsmicroarrayanalysis,miRNAsexpressionprofilesforhepatictissuesweredeterminedfrom15welldifferentiatedHCCtissuesand17poorlydifferentiatedHCCtissues.Concerns:Unnecessaryword;commaomitted;overuseofmiRNAs;misuseofplural;misuseoffrom;hyphenomitted.Final:Byemployingasensitive,high-throughput,andspecificmicroarrayanalysis,miRNAexpressionprofilesweredeterminedfor15well-differentiatedHCCtissuesandfor17poorlydifferentiatedHCCtissues.,ScientificWriting,Editing,andPublishing,Results,Session11,52,Original:InMHCC97Hcells,asshowninFigures2Aand2B,overexpressionofmiR-148adecreasedthemigratorypotential.AsshowninFigures2Cand2D,overexpressionofmiR-148aalsodecreasedthemigratorypotentialofMHCC97Lcells.Concerns:Toomanywords;repeatedwords.Final:Over-expressionofmiR-148adecreasedthemigratorypotentialofMHCC97Hcells(Figure2AandB)andMHCC97Lcells(Figure2CandD).,ScientificWriting,Editing,andPublishing,Results,Session11,53,Original:AsshowninFigures3Aand3C,overexpressionofmiR-148ablockedtheexpressionofVimentin,butimprovedtheexpressionofE-cadherin.Concerns:Toomanywords;impropercapitalization;overuseofexpression;improvedisnotprecise.Final:Over-expressionofmiR-148ablockedtheexpressionofvimentinbutenhancedthatofE-cadherin(Figure3AandC).,ScientificWriting,Editing,andPublishing,Results,Session11,54,Original:ThesedatademonstratedthatMiR-148ablockstheCSC-likepropertiesinHCCcells.Concerns:Toomanyword