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1、Case Report,Present history : Onset,40-year old male Transient “electric shock like” back and left shoulder pain Syncope Local hospital,Present history : hospital 1,Consciousness recovered (one hour after admission) Paroxysmal dull pain in left shoulder and lower back,Present history:hospital 1,Neur
2、ological Disorders? Neurological examination was normal. Cerebral computed tomography: normal Radiography: hyperosteogeny lumbar hyperosteogeny? Symptoms relieved: discharged,Otherwise Normal,Present history:hospital 2,Renal Failure? Chest stiffness right, 123/77mmHg. water hammer pulse (+) Heart Gr
3、ade (/6) sighing diastolic murmur at aortic valve area, which radiates toward the apex,General examination,Abdomen Mild, non-focal abdominal tenderness Lower extremity diminished left lower extremity pulses,LAB FINDINGS,Blood routine WBC 4.74G/L; Hb 129g/L Blood biochemistry Na 145mmol/L, Cl 111 mmo
4、l/L,K 4.1mmol/L, Glu 5mmol/L, Urea 5.7mmol/L, Cr 107mol/L, UA 482mol/L; CK 121IU/L, CK-MB 12.4IU/L, LDH-L 198 IU/L; AMY33 IU/L, LPS 57 IU/L, AFP4.8g/L; Thyroid function T3=1.44nmol/L,T4=102nmol/L,fT3=4.23pmol/L, TSH=3.75mIU/L,Otherwise Normal,LAB FINDINGS,Coagulation function PT=18S, INR=1.5, D-Dime
5、r: 2.4mg/L (2400g/L, normal:500g/L) ESR: 4mm/h,Imaging findings,Imaging findings,Imaging findings,Imaging findings,Imaging findings,CT angiography of chest and abdomen,discussion,Discussion:general,Acute aortic dissection (AAD) Aortic dissection may present with a variety of clinical manifestations,
6、Discussion:general,75% Misdiagnoses include: myocardial infarction cerebral infarction,Discussion:symptoms & signs,Painless: 5% Syncope:8% AAD should be considered in the differential diagnosis of syncope, even in the absence of pain,DISCUSSION:symptoms & signs,AAD may mimic an acute coronary syndro
7、me,DISCUSSION:symptoms & signs,DISCUSSION:IMAGING,Up to now, various non-invasive and invasive diagnostic steps are required to diagnose or to rule-out AAD in case of clinical suspicion,DISCUSSION:IMAGING,CT and MRI of patients with suspected AAD Sensitivity and specificity of CT: reaching 100% Sens
8、itivity of MRI is up to 95-100,DISCUSSION:imaging,Ultrasonic cardiograms (UCG) TAS (ultrasound of the abdomen) TEE (transesophageal echocardiography,DISCUSSION:lab,Determination of D-dimer D-Dimer: 2.4mg/L (2400g/L, normal:500g/L,Discussion:Treatment,Medication MAP 60 to 75 mmHg target HR:around 60b
9、pm Beta blockers and nitroprusside sodium Calcium channel blockers,Discussion:TREATMENT,Interventional therapeutic measures Cardiothoracic Surgery,DISCUSSION:CLASSIFICATIONS,Discussion:Prognosis,The long term follow-up The mortality rate: 68% 48hrs,Discussion:Summary,Key in the management of acute aortic dissection is to maintain a high level of suspicion for th
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