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1、1 定量药理学的发展及其在新药研制 与临床合理用药中的应用 2 定量药理学(Pharmacometrics) 定量研究解析药理学现象的边缘交叉学科 核心学科 生物药剂学（BiopharmaceuticsBiopharmaceutics） 群体药物动力学（Population Population Pharmacokinetics, PopPKPharmacokinetics, PopPK） 药物动力学/ /药效动力学（Pharmacokinetics Pharmacokinetics (B) Supra-additive interaction between two agonists; (C

2、) Infra-additive interaction between two agonists; (D) Partial agonist and full agonist; (E) Competitive agonist and full agonist; (F) Inverse agonist and full agonist. 134 定量药理学(Pharmacometrics) 定量研究解析药理学现象的边缘交叉学科 核心学科 生物药剂学（BiopharmaceuticsBiopharmaceutics） 群体药物动力学（Population Population Pharmacoki

3、netics, PopPDPharmacokinetics, PopPD） 药物动力学/ /药效动力学（Pharmacokinetics Pharmacokinetics & Pharmacodynamics, PK/PD& Pharmacodynamics, PK/PD） 模型化与仿真技术（Modeling & Simulation, Modeling & Simulation, M&SM&S） 135 什么是模型化与仿真？ 136 在临床各期中模型化与仿真的应用 137 NEWSPLOT PK_TOOL WinBMUPK NONMEM_TOOL 138 NewSPLOT - Graphic

4、ally Interpret NONMEMs Output 139 NewSPLOT - Original Output of NONMEM IDTIMEIPREETA1ETA2ETA3ALTASTCREAUREAAGEBWHGHT 1.00E+00 0.00E+00 0.00E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 1.00E+00 1.27E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.1

5、0E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 2.00E+00 1.86E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 3.00E+00 2.05E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 3.50E+

6、00 2.05E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 4.00E+00 2.01E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 5.00E+00 1.85E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01

7、4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 6.00E+00 1.63E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 8.00E+00 1.17E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 1.00E+01 7.94E-01 8.2

8、7E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 1.20E+01 5.16E-01 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 1.60E+01 2.02E-01 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+

9、01 6.50E+01 1.72E+02 2.00E+00 0.00E+00 0.00E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 1.00E+00 1.09E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 2.00E+00 1.65E+00 3.70E-02 8.67E-01

10、4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 3.00E+00 1.88E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 3.50E+00 1.92E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.6

11、5E+02 2.00E+00 4.00E+00 1.91E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 5.00E+00 1.81E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 6.00E+00 1.66E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+

12、01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 8.00E+00 1.28E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 1.00E+01 9.24E-01 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00

13、1.20E+01 6.42E-01 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 1.60E+01 2.87E-01 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 3.00E+00 0.00E+00 0.00E+00 # 6.47E-01 1.16E-01 1.40E+01 2.10E+01 1.01E+02 4

14、.54E+00 2.40E+01 6.00E+01 1.77E+02 3.00E+00 1.00E+00 1.43E+00 # 6.47E-01 1.16E-01 1.40E+01 2.10E+01 1.01E+02 4.54E+00 2.40E+01 6.00E+01 1.77E+02 3.00E+00 2.00E+00 2.13E+00 # 6.47E-01 1.16E-01 1.40E+01 2.10E+01 1.01E+02 4.54E+00 2.40E+01 6.00E+01 1.77E+02 140 NewSPLOT - Diagnostic Plots IDTIMEIPREETA

15、1ETA2ETA3ALTASTCREAUREAAGEBWHGHT 1.00E+00 0.00E+00 0.00E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 1.00E+00 1.27E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 2.00E+00 1.86E+00 8.27E-

16、02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 3.00E+00 2.05E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 3.50E+00 2.05E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01

17、6.50E+01 1.72E+02 1.00E+00 4.00E+00 2.01E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 5.00E+00 1.85E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 6.00E+00 1.63E+00 8.27E-02 7.76E-01 1.4

18、8E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 8.00E+00 1.17E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 1.00E+01 7.94E-01 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+

19、02 1.00E+00 1.20E+01 5.16E-01 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 1.60E+01 2.02E-01 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 2.00E+00 0.00E+00 0.00E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01

20、2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 1.00E+00 1.09E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 2.00E+00 1.65E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 3.0

21、0E+00 1.88E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 3.50E+00 1.92E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 4.00E+00 1.91E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+

22、01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 5.00E+00 1.81E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 6.00E+00 1.66E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 8.00E+00 1.28E+00

23、3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 1.00E+01 9.24E-01 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 1.20E+01 6.42E-01 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.3

24、0E+01 6.50E+01 1.65E+02 2.00E+00 1.60E+01 2.87E-01 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 3.00E+00 0.00E+00 0.00E+00 # 6.47E-01 1.16E-01 1.40E+01 2.10E+01 1.01E+02 4.54E+00 2.40E+01 6.00E+01 1.77E+02 3.00E+00 1.00E+00 1.43E+00 # 6.47E-01 1.16E-01 1.

25、40E+01 2.10E+01 1.01E+02 4.54E+00 2.40E+01 6.00E+01 1.77E+02 3.00E+00 2.00E+00 2.13E+00 # 6.47E-01 1.16E-01 1.40E+01 2.10E+01 1.01E+02 4.54E+00 2.40E+01 6.00E+01 1.77E+02 141 NewSPLOT - Explore the Fixed Effects IDTIMEIPREETA1ETA2ETA3ALTASTCREAUREAAGEBWHGHT 1.00E+00 0.00E+00 0.00E+00 8.27E-02 7.76E-

26、01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 1.00E+00 1.27E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 2.00E+00 1.86E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01

27、1.72E+02 1.00E+00 3.00E+00 2.05E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 3.50E+00 2.05E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 4.00E+00 2.01E+00 8.27E-02 7.76E-01 1.48E-01 1.3

28、0E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 5.00E+00 1.85E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 6.00E+00 1.63E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+

29、00 8.00E+00 1.17E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 1.00E+01 7.94E-01 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 1.20E+01 5.16E-01 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01

30、8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 1.60E+01 2.02E-01 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 2.00E+00 0.00E+00 0.00E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 1.00E+00 1.0

31、9E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 2.00E+00 1.65E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 3.00E+00 1.88E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+

32、00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 3.50E+00 1.92E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 4.00E+00 1.91E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 5.00E+00 1.81E+00 3.70E-02

33、8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 6.00E+00 1.66E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 8.00E+00 1.28E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.5

34、0E+01 1.65E+02 2.00E+00 1.00E+01 9.24E-01 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 1.20E+01 6.42E-01 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 1.60E+01 2.87E-01 3.70E-02 8.67E-01 4.83E-

35、02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 3.00E+00 0.00E+00 0.00E+00 # 6.47E-01 1.16E-01 1.40E+01 2.10E+01 1.01E+02 4.54E+00 2.40E+01 6.00E+01 1.77E+02 3.00E+00 1.00E+00 1.43E+00 # 6.47E-01 1.16E-01 1.40E+01 2.10E+01 1.01E+02 4.54E+00 2.40E+01 6.00E+01 1.77E+02 3.00E+00 2.00E

36、+00 2.13E+00 # 6.47E-01 1.16E-01 1.40E+01 2.10E+01 1.01E+02 4.54E+00 2.40E+01 6.00E+01 1.77E+02 142 NewSPLOT - Distribution of ETAs and Fixed Effects IDTIMEIPREETA1ETA2ETA3ALTASTCREAUREAAGEBWHGHT 1.00E+00 0.00E+00 0.00E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E

37、+01 1.72E+02 1.00E+00 1.00E+00 1.27E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 2.00E+00 1.86E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 3.00E+00 2.05E+00 8.27E-02 7.76E-01 1.48E-01

38、 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 3.50E+00 2.05E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 4.00E+00 2.01E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.

39、00E+00 5.00E+00 1.85E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 6.00E+00 1.63E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 8.00E+00 1.17E+00 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E

40、+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 1.00E+01 7.94E-01 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 1.20E+01 5.16E-01 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 1.00E+00 1.60E+01

41、 2.02E-01 8.27E-02 7.76E-01 1.48E-01 1.30E+01 2.10E+01 8.20E+01 4.36E+00 2.50E+01 6.50E+01 1.72E+02 2.00E+00 0.00E+00 0.00E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 1.00E+00 1.09E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.

42、05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 2.00E+00 1.65E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 3.00E+00 1.88E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 3.50E+00 1.92E+00 3.70E

43、-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 4.00E+00 1.91E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 5.00E+00 1.81E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01

44、 6.50E+01 1.65E+02 2.00E+00 6.00E+00 1.66E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 8.00E+00 1.28E+00 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 1.00E+01 9.24E-01 3.70E-02 8.67E-01 4.

45、83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 1.20E+01 6.42E-01 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E+02 2.00E+00 1.60E+01 2.87E-01 3.70E-02 8.67E-01 4.83E-02 1.50E+01 2.20E+01 7.84E+01 5.05E+00 2.30E+01 6.50E+01 1.65E

46、+02 3.00E+00 0.00E+00 0.00E+00 # 6.47E-01 1.16E-01 1.40E+01 2.10E+01 1.01E+02 4.54E+00 2.40E+01 6.00E+01 1.77E+02 3.00E+00 1.00E+00 1.43E+00 # 6.47E-01 1.16E-01 1.40E+01 2.10E+01 1.01E+02 4.54E+00 2.40E+01 6.00E+01 1.77E+02 3.00E+00 2.00E+00 2.13E+00 # 6.47E-01 1.16E-01 1.40E+01 2.10E+01 1.01E+02 4.

47、54E+00 2.40E+01 6.00E+01 1.77E+02 143 NEWSPLOT PK_TOOL WinBMUPK NONMEM_TOOL 144 PK-TOOL Parameter Transformation 145 PK-TOOL Preliminary Modeling 146 NEWSPLOT PK_TOOL WinBMUPK NONMEM_TOOL 147 WinBMUPK Teach/Research Tool for PK/PD Modeling and Simulation Private T(32), NDC(40), ADC(10, 32), ADCX(10,

48、 32), W(10, 32), PT(16), AIC(40), ZAIC(40) Private NCC(16), NCE(16), LAG(16), ZDCX(10, 32), NDP(16), TL(20), NDD(40), PN(16) Private PX(16), PTX(16), PTY(16), PRS(16), DFX(320, 17), Y(40), P(40) Private IND, JC, JS, TI, MDC, MT, HM, SS, MMM, F(40), XA(16, 17), X(20, 40) Private SSTEP, MC, SOG$, II,

49、SG, NX, XNN, XMM, XX, NY, YNN, YMM, YY Public Sub BMUPK() Rem = Rem NON-LINEAR LEAST SQUARE METHOD WITH TEMPORAL DISCARD PROCEDURE Rem FOR FITTING OF EXPERIMENTAL DATA TO PHARMACOKINETIC MODEL Rem = TMAX = 0: II = 0: SOG$ = Sheets(INPUT).Select Range(D1:X48).Cells = 1 TIT$ = H1: IND = H3: ITYPE = 0:

50、 KNW = H5: LMT = H7: LL = H9: DELT = H11: SSTEP = H13 MC = H15 TI = H17 For I = 1 To MC: AIC(I) = Cells(19, I + 7): Next I MDC = H21: MTT = H23: MSS = H25: MT = MTT For I = 1 To MDC: NDC(I) = Cells(27, I + 7): NDD(I) = NDC(I): Next I For J = 1 To MT T(J) = Cells(50 + J, 1) If TMAX = 0 And YMIN ADC(I

51、, J) Then YMIN = ADC(I, J) If YMAX ADC(I, J) Then YMAX = ADC(I, J) Next I 5 For I = 1 To MDC W(I, J) = 1 If KNW = 0 Then GoTo 15 If ADC(I, J) 0.00001 Then GoTo 25 PX1 = PX(I) - PT(I) If PX1 0.00001 Then GoTo 25 MDP = MDP + 1: NDP(MDP) = I: GoTo 30 25 MPD = MPD + 1: NCC(MPD) = I NCE(MPD) = I: PTY(I)

52、= PT(I) 30 Next I MPE = MPD: XNN = MSS - MPD: MMM = 1: JC = -1 JTR = -1: JS = -1: JP = -1: JLL = 0: NRP = 0 SS = 1E+35 Sheets(OUTPUT).Select Cells.Clear II = II + 1 Cells(II, 2) = NON-LINEAR LEAST SQUARE METHOD REGRESSION: II = II + 1 Cells(II, 4) = WINBMUPK : Range(B2:F2).Select: II = II + 1 Select

53、ion.Font.ColorIndex = 41 Selection.Font.Bold = True Range(B2:F2).Select With Selection .Borders(xlEdgeBottom).LineStyle = xlContinuous .Borders(xlEdgeBottom).Weight = xlMedium .Borders(xlEdgeBottom).ColorIndex = xlAutomatic .HorizontalAlignment = xlCenter .VerticalAlignment = xlCenter End With Cells

54、(II, 2) = PEKING UNIVERSITY SCHOOL OF PHARMACY - 2004: II = II + 2 Cells(II, 2) = TIT$: II = II + 2 Cells(II, 2) = ALL PARAMETERS WERE DETERMINED: II = II + 2 Cells(II, 2) = INITIAL PARAMETERS: II = II + 1 If MPD 0 Then GoTo 35 SSMIN GoTo 100 35 If MSS - MPD 0 Then GoTo 210 For I = 1 To MPD TEMPC =

55、TEMPC + Str(PT(NCC(I) + Next I: Cells(II, 2) = TEMPC: II = II + 2: L = 1 40 For I = 1 To MPD IP = NCE(I) If PT(IP) PX(IP) Then GoTo 45 PT(IP) = (PX(IP) + PTY(IP) * 0.5: GoTo 50 45 If PT(IP) PN(IP) Then PT(IP) = (PN(IP) + PTY(IP) * 0.5 50 PTX(IP) = PT(IP) Next I 55 SSMIN If JTR 0 Then GoTo 70 If JLL

56、= 18 Then GoTo 65 NRP = NRP + 1: GoTo 85 65 II = II + 1: Cells(II, 2) = THE ENDPOINT OF FITTING: II = II + 2: KKK = 1 GoTo 165 70 If NRP = 0 Then GoTo 75 Cells(II, 2) = HALF CIRCULATION: + Str(NRP): II = II + 1 If NRP = 0 Then GoTo 75 75 Cells(II, 2) = L = + Str(L): Cells(II, 3) = J = + Str(JLL): Ce

57、lls(II, 4) = SS = + Str(SS): II = II + 1 If ITYPE = 0 Then GoTo 80 For I = 1 To MPD: If I = 1 Then Cells(II, 2) = L = + Str(L): II = II + 2 FORMAT_NUMBER PT(NCE(I), CC$ Cells(II, 2) = P( + Str(NCE(I) + ) = + CC$ Next I 80 NRP = 0 85 JLL = 0 MPD = MPE 148 WinBMUPK Modeling or Simulation Output Window

58、 Private T(32), NDC(40), ADC(10, 32), ADCX(10, 32), W(10, 32), PT(16), AIC(40), ZAIC(40) Private NCC(16), NCE(16), LAG(16), ZDCX(10, 32), NDP(16), TL(20), NDD(40), PN(16) Private PX(16), PTX(16), PTY(16), PRS(16), DFX(320, 17), Y(40), P(40) Private IND, JC, JS, TI, MDC, MT, HM, SS, MMM, F(40), XA(16

59、, 17), X(20, 40) Private SSTEP, MC, SOG$, II, SG, NX, XNN, XMM, XX, NY, YNN, YMM, YY Public Sub BMUPK() Rem = Rem NON-LINEAR LEAST SQUARE METHOD WITH TEMPORAL DISCARD PROCEDURE Rem FOR FITTING OF EXPERIMENTAL DATA TO PHARMACOKINETIC MODEL Rem = TMAX = 0: II = 0: SOG$ = Sheets(INPUT).Select Range(D1:

60、X48).Cells = 1 TIT$ = H1: IND = H3: ITYPE = 0: KNW = H5: LMT = H7: LL = H9: DELT = H11: SSTEP = H13 MC = H15 TI = H17 For I = 1 To MC: AIC(I) = Cells(19, I + 7): Next I MDC = H21: MTT = H23: MSS = H25: MT = MTT For I = 1 To MDC: NDC(I) = Cells(27, I + 7): NDD(I) = NDC(I): Next I For J = 1 To MT T(J)

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